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Biomedical subjects

N Minkov

Publications and source records attributed to N Minkov.

At least 37 records · Page 2Linked to original sources
PubMed1985

[Acute papillary necrosis in transplanted kidney].

After a short literature survey, indicating the rarity of acute papillary necrosis in transplanted kidneys, the authors reported one of their patients, aged 32, with transplanted dead body kidney from a male, aged 30, with blood group compatibility and compatibility of two antigens in locus A. Two hemodialysis were necessiated because of acute tubular necrosis in the transplant. After the second one, performed 10 days after the transplantation, the patient felt very strong pains in the region of the transplant, edema around it and hypovolemic shock. The kidney was explanted and necrosis of the majority of the papillae in it--established, and around it--blood collection. After that incidence, the patients had three severe gastrointestinal hemorrhages with shocks, that necessitated profuse transfusion of blood. Their cause was a small erosion, about a lentil seed, at the pyloric opening, resulting from the cortico-therapy and periodic heparinization for dialysis. The patients was reanimated and returned to programmed chroniodialysis. The possible causes for papillary necrosis are discussed, most acceptable being two of them them--urostasis from 1200 ml urine in the urinary bladder, that required catheterization before the incidence and/or compression and ischemia of the transplanted kidney by the blood collection around it.

Acute Disease↗
PubMed1985

[Acute recurrence of focal-segmental glomerulosclerosis in the kidney transplanted from mother to son with rapidly progressing failure of renal function].

After a brief survey, stressing upon the high susceptibility of the focal-segmental glomerulosclerosis to recurrences in transplated kidney, the authors announced one of their own observations on a youth, aged 19, that was transplated a kidney from a living donor--his mother. The basic disease in the acceptor led to chroniodialysis after 20 months of the first clinical signs. In spite of the high diuresis, that was observed after the transplantation of the maternal kidney, proteinuria persisted as early as the first days after the transplantation, creatinine did not reach the normal values and after I month chroniodialysis was again included, followed by detransplantation. The cause of that malignant course of the disease and in the transplanted kidney, the authors admitted to be the high tissue compatibility between the donor-mother and acceptor--son, one antigen in locus A and two antigens in loci B and DR. They think that with a malignant course of the focal segmental glomurolosclerosis, living donor for kidney transplantation should not be used and on no account--in case of high tissue compatibility.

Acute Disease↗
PubMed1985

[Treatment of acute and chronic urological infections with azlocillin--clinical and microbiological research].

The authors present their results from the treatment of urological infections with the new semisynthetic penicillin antibiotic azlocillin (acyl-ureide-penicillin) in 86 patients with various, in kind and clinical manifestations, infections of the urinary system. The susceptibility was determined of the isolated bacterial causative agents of the urological infections to azlocillin and to the other antibacterial preparations available in our country. It was established that 52,7% of Gram-negative microorganisms were susceptible to the preparation, and over 80%--of the Gram-positive microorganisms. The highest number of susceptible strains were established in pseudomonas, coli, enterobacter, klebsiella and proteus. The results from the clinical study reveal that 51,2% of the patients were cured by the end of the therapeutic course and abatement or considerable improvement, was observed in all, of the clinical and paraclinical indices, suggesting urological infection. No allergic or toxic manifestations were observed. The absence of nephrotoxicity makes that new, for our practice, antibiotic extremely valuable for the patients with renal insufficiency. The most general conclusion from that study is that azlocillin, with its effectiveness, comes close to the most potent modern antibacterial preparations, with no toxicity characteristic for aminoglucoside antibiotics.

Adolescent↗
PubMed1985

[Pipemidinic acid as a urinary antiseptic--microbiological and clinical study].

The authors present the results from the microbiological and clinical studies about the potentialities of pipemidinic acid in the treatment of uroinfections. Pipemidinic acid was established with the study on 375 bacterial strains, isolated from the urine of urological patients to have a very good in vitro effect as regards E. coli, Citrobacter, Proteus retgeri, Proteus mirabilis, Klebsiella and Enterobacter, and in case of those microorganisms, it gives way only to some aminoglucoside antibiotics. The admit that with those causative agents of uroinfections, the pipemidinic acid could be the agent of choice. The percentage of susceptible strains is low in case of Seratia, Proteus vulgaris, Pseudomonas and Acunetobacter. Sanation of the uroinfection was attained in 56.2 per cent of the patients from the 32 patients treated with persistent, most often nosocomial uroinfection, by the pipemidinic acid (in the form of the preparation palin), and a reduction of the bacterial number to insignificant values--in 12,6%. Obvious clinical improvement was established in almost all patients treated, manifested with fading or considerable reduction of the subjective and physical symptoms of the uroinfection, in parallel with a normalization or improvement of the paraclinical laboratory indices as well. In conclusion, it was emphasized that the introduction of that uroantiseptic in the practice will broaden the possibilities of effective treatment of uroinfections.

Aminoglycosides↗
PubMed1984

[Brulamycin in the treatment of urinary infections--microbiological and clinical research].

The authors report the results frop microbiological and clinical studies of the new aminoglucoside antibiotic brulamycin. The susceptibility of 12 392 bacterial strains was determined versus brulamycin and the other routinely applied antibacterial preparations in our country and established that, according to that index brulamycin, in vitro, gives way only to amikin. Fifty two patients with severe uroinfections were treated (30 adults and 22 children) and healing (sterilization of urine) was attained in 10 per cent of the adults and 40,9 per cent of the children. Improvement (reduction of the bacterial number to insignificant value) was established in 42,3 per cent of all patients. In parallel with the favourable microbiological indices, improvement or normalization of the clinical and paracminical indices of the uroinfection were also established. The antibiotic is very well tolerated, by children one-year of age, including. With those properties brulamycin should widely be administered in the clinical practice of uroinfection treatment.

Adolescent↗
PubMed1984

[Results of operative treatment of vesico-ureteral reflux and megaureter in childhood].

The evaluation of 620 reimplantations of the ureter into the bladders of 566 children with megaureter and vesico-ureteral reflux is taken as the basis of an analysis of the indications for operative treatment, the most economical methods of operation and the early and late results. Our own scale of the degree of development of the disease was used to determine whether operation was indicated. The various techniques of operation and the postoperative results are discussed. In order to improve the evaluation of the results the patients are classified into 4 groups according to the degree of affliction.

Adolescent↗
PubMed1983

[Surgical treatment of distal hypospadias].

From a total of 1,164 cases of hypospadias operations between 1966 and 1981 we report our experience in the operative treatment of distal hypospadias (n = 208). The best time for hypospadias repair is between 3 and 6 years of life. With correction of chordee it is most important to excise all penile skin of poor quality. The standard operation for the correction of chordee is the procedure described by Erdely and Bosio. If there is insufficient penile skin, scrotal skin is used to cover the skin gap. In the case of a small scrotum, only the proximal defect is covered by scrotal skin and the distal part by the procedure described by Blair, Browne, Ombredanne and Edmunds. The formation of a new urethra is accomplished with the use of Duplay's principle. We prefer subcutaneous running suture under tension with rubber bands. In the case of multiple previous operations and failed reconstruction of the urethra a tube of scrotal skin is formed and brought to the tip of the penis subcutaneously. Many authors have described numerous procedures for the treatment of hypospadias. We have combined the advantages of all techniques and formed our own approach always taking the individual case into consideration. With this approach we have good results in the treatment of hypospadias.

Child↗
PubMed1982

[Acute papillary necrosis in the transplanted kidney].

After a brief literature survey revealing the rarity of the papillary necrosis in transplanted kidneys, the authors report the case of one of their patients, aged 32, transplanted a corpse kidney of a 30-year old male with blood-group compatibility and with coincidence of the two antigens in locus A. Regardless of the increased diuresis of the patient to 3-4 1 within 24 hours, its nitrogen bodies persisted their elevation, necessitating two dialysis. After the second dialysis performed on the tenth day after the transplantation, the patient had very strong pains in the transplantation region, edema around it and a hypovolemic shock. The kidney was explanted and at the examination--necrosis of all papillae in it was established. Blood collection was found round the kidney. The same patient, after that incidence, suffered three successive severe gastrointestinal hemorrhages with shock that necessitated abundant blood transfusions. The cause was a small erosion, about the size of a millet, at the pyloric lumen, result from corticotherapy and favoured by the periodical heparinization during the following hemodialysis. The patient was reanimated and put again on a programmed chroniodialysis.

Acute Disease↗
PubMed1982

[Results of ultrasonic diagnosis of patients with renal transplants].

The echography of transplanted kidney is a modern noninvasive investigation method with significant information value. It is easily applicable even in cases of the gravest states of the patients, allowing the dynamic observation almost immediately in the post-transplantation period. The early and chronic crisis of transplant rejection is excellently diagnosed by echography as well as of perirenal liquid collections, arterial and venous thrombosis, obstructions of excretory ducts. Results are reported from 37 echographic examinations of II kidney transplanted patients, manifesting the following complications: 8 acute crises of transplant rejection, 6--acute tubular necrosis, 3--vascular thrombosis and renal infarctions, 2--perirenal collections. 3--lightly dilated pyelo-calix system. The majority of the echographic diagnoses were confirmed by clinical-laboratory methods, X-ray examination methods and at operation.

Graft Rejection↗