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Biomedical subjects

N McIntyre

Publications and source records attributed to N McIntyre.

At least 145 records · Page 8Linked to original sources
PubMed1971

Cardiac beriberi: two modes of presentation.

Two patients suffering from cardiovascular beriberi presented with different clinical manifestations. One had the classical features of a high cardiac output with raised jugular venous pressure and gross oedema. The other was in fulminating heart failure with clinical evidence of a low cardiac output but no peripheral oedema. The latter type of beriberi (shoshin) is rare. Cardiovascular beriberi has a high mortality when untreated. Both patients responded dramatically to thiamine, and this emphasizes the importance of considering thiamine deficiency as a cause of heart failure even when the cardiac output is low.

Adult↗
PubMed1971

Chronic hepatitis.

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Chronic Disease↗
PubMed1971

Cholesterol biosynthesis in transplantable hepatomas: evidence for impairment of uptake and storage of dietary cholesterol.

Cholesterol feeding inhibits cholesterol biosynthesis in normal but not in malignant liver tissue. It has been postulated that hepatomas have suffered a specific intracellular deletion of the cholesterol feedback control mechanism, but there is little direct evidence to support this hypothesis. Rats bearing Morris transplantable hepatomas were fed high cholesterol diets for periods of up to 21 days. Cholesterol biosynthesis, as expected, was suppressed in the normal liver but not in hepatomas. The livers accumulated large amounts of cholesteryl ester but the hepatomas showed little or no increase in ester content. Cholesterol-1alpha-(3)H was administered intragastrically to other tumor-bearing rats. Uptake of radioactivity by the tumors was much slower than by normal liver. Comparison of the specific activities of liver and tumor cholesterol with that of the plasma suggested that the liver took up dietary cholesterol selectively from the blood, while the appearance of radioactivity in the tumors could be explained by slow equilibration with plasma cholesterol. Our results suggest that the insensitivity of cholesterol biosynthesis to dietary cholesterol in hepatomas could be explained by an impairment in the uptake and storage of dietary cholesterol and that the concept of an intracellular deletion of the feedback mechanism requires further evidence.

Acetates↗
PubMed1971

Sterols in the small intestine of the rat, guinea pig, and rabbit.

The sterol content and composition of the small intestinal muccsa has been studied in the rat, guinea pig, and rabbit. In the three species, noncholesterol sterols formed a large proportion of the total sterol content. In the rat, the contribution due to plant sterols was much smaller than in the guinea pig and rabbit, but in all three species the amount of campesterol present seemed disproportionately large compared with beta-sitosterol. These observations are presented as evidence that the intestinal mucosa is able to discriminate in its uptake of sterols from the lumen. The presence of plant sterol at all levels of the intestine makes it clear that luminal sterols can be taken up throughout the small bowel, but the data suggest that the upper intestine is the major site of sterol uptake. In the rat, the sterol composition of the intraluminal contents was also studied after its separation by ultracentrifugation into an aqueous (or micellar) phase and a sediment. Examination of the content and composition of the intraluminal sterols at different levels of the intestine provided support for the idea that the major site of cholesterol absorption was in the upper small intestine. The major part of the intraluminal sterol was found in the sediment; precipitation did not, however, render sterols unavailable for absorption and the micellar sterols reflected closely the pattern found in the corresponding sediment.

Animals↗