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Biomedical subjects

N Mascolo

Publications and source records attributed to N Mascolo.

77 records · Page 5Linked to original sources
PubMed1980

Endogenous inhibitor of prostaglandin biosynthesis in inflammation.

Rat serum exhibits a concentration-related inhibition of PG biosynthesis by rat peritoneal leucocytes phagocytosing killed bacteria. The serum inhibitory potency is increased by inducing carrageenan foot oedema in animals whereas it is not altered by dextran oedema. The increase of the inhibitory activity of serum from carrageenan-treated rats develops in a time-dependent way reaching its maximum at 24 h. Since the increased inhibitory activity does not occur following indomethacin administration we suggest that PG formation at the inflammatory site may stimulate the ability of serum to inhibit PG biosynthesis.

Animals↗
PubMedDate not supplied

Local anti-inflammatory activity of Tamus communis.

The effects of an ethanol root extract of Tamus communis were documented on cotton pellet granuloma in rats. The inhibitory effect of the solvent-free extract (5-20 mg/pellet) on granuloma formation was comparable to that of reference drugs benzydamine HCl (5-20 mg/pellet) and hydrocortisone (5 mg/pellet). The local anti-inflammatory activity of T. communis was not accompanied by a decrease in body weight.

Administration, Topical↗
PubMedDate not supplied

Ethnopharmacology of Calotropis procera flowers.

An ethanolic extract of the flowers of Calotropis procera was investigated for anti-inflammatory, antipyretic, analgesic and antimicrobial activities. The plant extract reduced the paw swelling induced by carrageenan by 37%, fever in rats by 40% and showed some weak effect in rats on the writhing induced by acetic acid. The growth of both gram-positive and gram-negative bacteria was significantly inhibited. A dose-dependent effect on prostaglandin release was also observed.

Animals↗