Biomedical subjects
Publications and source records attributed to N Maruchi.
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To study the epidemiologic association between Hashimoto's thyroiditis and malignancies, autopsy protocols (1959--1974) were examined at the Tokyo University Hospital. The study cases were classified according to major cause of death, including breast and lung cancer. The relationship between thyroid changes and breast cancer was not significant; however, a significant association between thyroid alteration and lung cancer was identified. This finding suggested that Hashimoto's thyroiditis and related changes could be one of the risk factors for lung cancer among Japanese women.
Results of a nationwide survey show an uneven distribution of 'thyroidologists' and special facilities for the diagnosis and treatment of thyroid disease in Japan. A case is made for more systematic resource allocation in regional planning.
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All confirmed cases of pancreatic carcinoma in bona fida residents of Olmsted County, Minnesota, from 1935 through 1974 were identified and reviewed. The average annual age-adjusted incidence rates were 7.4 for males and 3.5 for females per 100,000 population. Rates increased with age for both sexes and increased slightly over the 40-year period of study, with lower incidence rates observed for rural inhabitants in the first 2 decades. At the time of diagnosis, almost 75% of patients were 60 years of age or older and adenocarcinoma was histologically identified in 92% of the cases. One-year survival was 11%, and all patients died within 3 years of the initial diagnosis. An association between pancreatic carcinoma and diabetes was noted. There does not appear to be a clear association with cholelithiasis or chronic pancreatitis. There was a high percentage (20%) of multiple primary carcinomas and an overrepresentation of metal workers observed among patients with pancreatic carcinoma.
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The present study was designed to examine the epidemiological association of food consumption with cancer mortality in Japan, if any, in comparison with similar examinations in developed countries including Japan, in a search for dietary factors in cancer etiology. Whereas food consumption patterns in Japan was believed to be specific among developed countries, this study revealed that the correlation matrix among major foods both for international and Japanese data made it possible to categorize these foods into two groups with some similar patterns, since there should be observed a positive or negative correlation for each pair of foods. The patterns for correlation of food consumption to cancer mortality in Japan were found to be considerably different from those in developed countries, and this suggested that the epidemiological association between the two in Japan, if any, could be specifically evaluated from that in develop countries. The urban-type region for food consumption in Japan, however, indicated a possible westernization for the relation of food consumption to cancer mortality as well as for food consumption patterns, whereas the traditional Japanese region for food consumption did not indicate any similarity with westernization for the relationship between food consumption and cancer mortality, as well as for food consumption patterns. The above findings also suggested that there might be a possible significance for the regionalization of Japan in such studies, and that the urbanization of food consumption patterns in Japan would show that this country has a similar pattern of association between food consumption and cancer mortality as observed among developed countries in Europe and/or North America.
The question of a possible association between Hashimoto's thyroiditis and breast cancer was evaluated in (1) an autopsy series and (2) a follow-up of a cohort of patients with Hashimoto's thyroiditis at the Mayo Clinic. In the autopsy study, 174 subjects with histologic diagnosis of Hashimoto's thyroiditis were matched with a control group. There was no significant difference in the frequency of a history of breast cancer in the two groups. In the cohort of Olmsted County residents with a clinical or histologic diagnosis of Hashimoto's thyroiditis for whom there was a substantial period of follow-up, no excess frequency of breast cancer was note. These results contrast with those of a recent study reporting that Japanese women with Hashimoto's thyroiditis were a high risk group for breast cancer.