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Biomedical subjects

N Maffulli

Publications and source records attributed to N Maffulli.

At least 127 records · Page 7Linked to original sources
PubMed1997

Modified Burton and Pellegrini procedure for trapezium excision, ligament reconstruction and interposition arthroplasty of the tendon of flexor Carpi radialis.

GOAL OF SURGERY: Relieve of pain and increased stability at the base of 1st metacarpal. INDICATIONS: Painful degenerative and inflammatory arthritis in trapeziometacarpal joint (TMCJ). CONTRAINDICATIONS: Patients not willing to undergo lengthy intensive postoperative rehabilitation. Rheumatoid arthritis (relative). POSITIONING AND ANAESTHESIA: Supine. Hand table. General or regional anaesthesia. SURGICAL TECHNIQUE: Modification of the Burton-Pelligrini operation by using half of the flexor carpi radialis for interposition between base of 1st metacarpal and scaphoid. Stabilization with a Kirschner wire. In the presence of scaphotrapezoid arthritis an arthrodesis of this joint is performed for better pain control. POSTOPERATIVE MANAGEMENT: Immobilization in a below elbow cast for 6 weeks. Then active physiotherapy, night splint for another 6 weeks. POSSIBLE COMPLICATIONS: Fracture while drilling the base of the 1st metacarpus, migration of Kirschner wires, injury to the radial artery and cutaneous nerves. RESULTS: Out of 15 patients 12 (14 thumbs) were followed for at least 6 months. In 11 patients the shape of the hand was normal and 10 patients were satisfied with the result of the operation. Complications included: twice postoperative migration of Kirschner wires, and once intraoperative tearing of the tendon which had to be sutured.

Journal Article↗
PubMed1997

Assessment of late results of surgery in talipes equino-varus: a reliability study.

UNLABELLED: The variability of a method for clinical and functional assessment of the long-term results of surgical correction of idiopathic congenital talipes equino varus was studied in ten boys and four girls (average age: 19.1 (SD 2.3 years); 22 affected feet) with radiographical evidence of fusion of the foot and ankle ossification centres. Patients were measured twice, 1 week-1 month apart, by the same investigator and were assessed twice on each visit. Assessment included anthropometry, functional assessment and subjective functional evaluation. Calf circumference, skinfold thickness, foot length and width were highly reproducible. Foot length was not significantly influenced by the operation whereas calf circumference, skinfold thickness and foot width were. Although highly reproducible, hopping was not significantly affected by operation. Active and passive range of motion were significantly different. Each was highly reproducible and both were significantly affected by the operation. Patients reported a high and highly reproducible (within two points) functional level. CONCLUSION: An assistant-administered functional questionnaire together with measurement of active and passive range of motion allows easy, valid and reproducible assessment of long-term results of surgery for idiopathic congenital talipes equino-varus correction. A significant effect of the number and type of operation was evidenced.

Adolescent↗
PubMed1997

Electrical stimulation prevents immobilization atrophy in skeletal muscle of rabbits.

OBJECTIVE: To investigate the effect of unilateral cast immobilization with and without surface electrical stimulation (ES) on the tibialis anterior (TA) muscle of rabbits. DESIGN: Prospective randomized trial. SETTING: University medical school. ANIMALS: 53 New Zealand White rabbits (aged 54 to 63 days, weight 1.73 to 1.91 kg). METHODS AND INTERVENTION: Random assignment, for a 3-week period, to one of four groups: C group (control group), I group (immobilization group), S group (group of electrical stimulation which was stimulated isometrically at 50 Hz, 30 minutes per day, 5 times a week), and IS group (immobilization group which, like the S-group, received electrical stimulation). OUTCOME MEASURES: Muscle wet wight, muscle fiber cross-sectional area, muscle fiber types, and muscle capillary supply. RESULTS: Muscle wet weight decreased significantly in the I group by 19% (p < or = .05), with a corresponding significant reduction in the total muscle fiber cross-sectional area of 26% (p < or = .05). No significant changes were observed in muscle wet weight and muscle fiber cross-sectional area in the S and IS groups. Interstitial fibrosis was observed in the I group and occasionally in the IS group. No significant changes in the total number of muscle fiber types I and II were found in all experimental groups. The capillary supply of the S and IS groups did not change significantly. However, capillary-to-fiber ratio was significantly reduced by 20% with a simultaneously nonsignificant increase in capillary density (capillaries/mm2) of 11% (p > .05) in the I group. Furthermore, muscle fiber regeneration was observed predominantly in the I group. CONCLUSIONS: In this experimental model, ES effectively prevented immobilization-induced muscle atrophy by minimizing reduction of muscle fiber cross-sectional area, interstitial fibrosis, and impaired blood supply.

Animals↗
PubMed1997

Pulsed magnetic and electromagnetic fields in experimental achilles tendonitis in the rat: a prospective randomized study.

OBJECTIVE: To investigate the effects of pulsed magnetic fields (PMF) and pulsed electromagnetic fields (PEMF) on healing in experimental Achilles tendon inflammation in the rat. DESIGN: Prospective randomized trial. SETTING: University medical school. METHODS: Exposure of the Achilles tendon and injury by a weight of 98.24 g falling from a height of 35cm in 180 male Sprague-Dawley rats. INTERVENTION: A daily 15-minute session with PMF of 17Hz or 50Hz, or PEMF of 15Hz or 46Hz, or a sham session. OUTCOME MEASURES: Random sacrifice 2 hours after the operation, and at 1, 3, 7, 14, or 28 days. Assessment of water content, weight, and histological appearance of the tendons. RESULTS: The time from injury and the various treatment modalities exerted a significant influence on the water content of the tendon after the injury (two-way ANOVA, p = .02). At day 3, the water content of the PEMF 46Hz group was significantly higher than in the other groups, decreasing sharply by day 7, and being similar to the other groups thereafter. By the end of the experiment, the PEMF 15Hz group was not significantly different from the control group. At day 7, the PMF 50Hz group showed significantly lower water content than the control group (p = .03), but at 14 days the PMF 50Hz group was not significantly different from the control group. PMF 50Hz suppressed the extravascular edema during early inflammation. PMF 17Hz showed a similar initial trend, producing a consistent lower water content throughout the experiment, reaching statistical significance by the end of treatment. By the end of the experiment, the collagen fibers had nearly regained their normal alignment in all groups, with a more physiological alignment seen in the PEMF 17Hz group. CONCLUSIONS: The tendon returned to histological normality in all groups, but the PMF 17Hz group showed better collagen alignment by the end of the study. PMF 17Hz resulted in a greater reduction of inflammation, with a better return of the tendon to histological normality. Different PMF and PEMF could be applied according to when treatment is started after the injury. If there is no delay between injury and beginning of pulsed magnetic treatment, PMF 17 should be used.

Achilles Tendon↗
PubMed1997

Knee arthroscopy in Chinese children and adolescents: an eight-year prospective study.

In the period January 1985 to December 1992, 69 Chinese boys and 20 Chinese girls (average 14.6 years, age range 6 to 16 years) with a total of 92 involved knees underwent examination under anaesthesia and knee arthroscopy. Two thirds of the patients were engaged in sports activities. A haemarthrosis was present in 51 patients. In one patient, Staphylococcus aureus was shown, and in two children a serous-purulent aspirate grew Mycobacterium tuberculosis. The lateral meniscus was torn in four knees and the medial meniscus in six. An intact discoid lateral meniscus was found in five girls. Three partial anterior cruciate ligament (ACL) tears, three complete ACL tears and two posterior cruciate ligament tears were diagnosed. One child had an osteochondral defect of the lateral femoral condyle accompanying an ACL and a lateral meniscal tear. Nonspecific synovitis of unknown etiology was diagnosed in six patients who had presented subacutely with at least a 2-month history of a symptomatic monoarticular knee effusion with low grade local inflammation and no history of major trauma. The synovitis gradually resolved over a 6- to 10-month period after arthroscopy. Knee arthroscopy in children and adolescent patients is safe, gives a high diagnostic accuracy, and allows treatment of a variety of intraarticular conditions. This study also demonstrates that the range of intraarticular knee problems found in Chinese children and adolescents differs from that described in their Western counterparts.

Adolescent↗
PubMed1997

Reimplantation of the totally extruded talus.

We present two cases of traumatic total extrusion of the talus, leaving no soft-tissue attachment. The management of this rare injury is controversial. These cases were managed by reimplantation of the tali. The tali revascularised and survived without collapse. One patient developed posttraumatic osteoarthritis of the ankle.

Accidental Falls↗
PubMed1997

Ender nailing for ipsilateral femoral shaft fractures after Austin-Moore hemiarthroplasty.

BACKGROUND: The management of ipsilateral femoral shaft fractures after hemiarthroplasty is controversial. METHODS: Fifteen patients (average age 82.4 +/- 8 years) with ipsilateral femoral shaft fractures after uncemented hemiarthroplasty were treated by closed reduction and Ender nailing. Under radiographic control, closed reduction was attempted. If not possible, cerclage of the shaft fracture was accomplished through a limited lateral approach. Ender nails were then inserted well past the tip of the stem of the prosthesis. RESULTS: There were a superficial wound infection and a deep vein thrombosis. At 6 months, five patients had died, and backing out of the nails necessitated removal in one patient. At 1 year, nine patients were still alive. Of these, seven were able to walk with aids. At 2 years, seven patients were still alive and were walking with aids. Two patients presented shortening of more than 1.5 cm of the operated femur. After an average of 5 years, 11 patients were dead, two were still walking, and two were bedridden. CONCLUSIONS: The technique described is an option in the treatment of fractures of the ipsilateral femoral shaft after uncemented hemiarthroplasty.

Aged↗
PubMed1997

Relationship between isokinetic concentric and eccentric contraction modes in the knee flexor and extensor muscle groups.

We investigated whether in normal subjects isokinetic concentric and eccentric strength variables were related in order to have a better picture in relation to rehabilitation and possible injury prevention. We studied the relationship between isokinetic concentric and eccentric peak torque, total work, and average power of knee extension and knee flexion at 60 degrees/sec and 120 degrees/sec in 42 young Chinese adults (22 males, age = 27 +/- 6.9 years; 20 females, age = 24.9 +/- 5.05 years) using the Cybex 6000 isokinetic dynamometer. Repeated analysis of covariance was used to compare the means between concentric and eccentric variables adjusted by limb dominance, speed of testing, and the muscle groups tested. A highly significant correlation was found between all concentric and eccentric variables, with correlation coefficients (r) ranging from 0.67 to 0.93. All but two of the eccentric variables were significantly greater than the concentric variables. Concentric and eccentric knee flexion to knee extension (H:Q) ratios were poorly correlated, with r ranging from 0.359 to 0.645. Although there is an acceptably high correlation between isokinetic concentric and eccentric strength variables of knee flexion and extension in young healthy individuals, we recommend measuring concentric and eccentric strength to plan a proper rehabilitation program and to assess muscle groups in a given contraction mode.

Adult↗
PubMed1997

Avulsion of the tibial tuberosity: muscles too strong for a growth plate.

PURPOSE: To ascertain whether there were significant knee extension strength differences between two adolescent male gymnasts (patient 1: age, 14.5 years; height, 159.3 cm; weight, 52.2 kg; patient 2: age, 15 years; height, 160.6 cm; weight, 54.8 kg) with avulsion of the tibial tuberosity associated with avulsion of the patellar tendon. CASE SUMMARY: Two adolescent male gymnasts underwent open reduction and internal fixation for avulsion of the tibial tuberosity associated with avulsion of the patellar tendon. Isometric extension strength of the contralateral uninjured knee and of the operated knee was significantly greater than for nonathletic adolescents of the same age (one-way analysis of variance [ANOVA], p = 0.001), and was at a higher part of normal strength than their gymnastic peers. DISCUSSION: A maximal contraction of the quadriceps is able to overcome the strength of the upper tibial epiphysis disrupting the extensor mechanism of the knee. RELEVANCE: Greater-than-usual strength, although normally of no undesired consequence, may play a role in avulsion injuries of major muscles.

Adolescent↗
PubMed1997

Ipsilateral fractures of the proximal ulna and distal radius (Colles type).

A 43-year-old female fell backward outside her home while carrying a watering can. She sustained an ipsilateral fracture of the proximal ulna and distal radius (Colles fracture). The ulnar fracture was plated, and the Colles fracture was managed by closed reduction and percutaneous Kirschner wiring. The patient recovered without incident. This association of forearm fractures is unusual. Both fractures can be caused by a fall on the hand with the wrist in mid-extension and the elbow flexed, and they probably occurred in quick succession.

Accidental Falls↗
PubMed1997

Dual-energy X-ray absorptiometry predicts bone formation in lower limb callotasis lengthening.

The rate of regenerate bone mineral content (BMC) acceleration was studied using dual-energy X-ray absorptiometry (DEXA) in callotasis lengthening of the lower limb. Eleven youngsters (age range 5-17 years) undergoing callotasis lengthening for congenital, post-traumatic or post-infective conditions were studied longitudinally. Patients were initially scanned once a week until completion of the lengthening phase, and at 2-week intervals thereafter until removal of the fixator. They were subsequently followed up at regular intervals on an outpatient basis for up to 2 years after removal of the fixator (average, 14 months). The BMC accretion slopes exhibited by the patients and the rate of new bone formation allowed the identification of three groups. In the fast formation group, the rate of new bone formation was 0.3-0.6% per day. In the moderate formation group the rate of new bone formation is 0.1-0.3% per day, while in the poor formation group the rate of new bone formation is < 0.1% per day. From the analysis of time graphs, a direct correlation emerged between early bone formation and subsequent bone mineral content accretion. Measurement of BMC during callotasis lengthening in the lower limb allows precise monitoring of the process. It may prove useful to prevent complications occurring after removal of the fixator at an unduly early stage, such as plastic deformation and fracture through the regenerate bone. It may be used to predict the bone formation rate in a given patient, and to implement measures to try to influence it.

Absorptiometry, Photon↗
PubMed1997

Effect of basic fibroblast growth factor. An in vitro study of tendon healing.

The effect of basic fibroblast growth factor on the proliferative and chemotactic response of cultured rat patellar tendon fibroblasts was studied in an in vitro wound closure model. In quiescent confluent fibroblast culture, a uniform cell free zone, or wound, was generated mechanically as an in vitro wound. The width of the cell free zone was measured at 0, 6, 12, and 24 hours after the injury, in the presence of 0, 2, 10, or 50 mg/mL of basic fibroblast growth factor. Basic fibroblast growth factor, at a concentration of 10 ng/mL, significantly accelerated wound closure, resulting in almost complete closure by 24 hours after the injury. Basic fibroblast growth factor, at a concentration of 2 ng/mL, significantly enhanced cell proliferation as estimated by 5-Bromo-2'-deoxyuridine incorporation, but increasing the concentration of the growth factor to 50 ng/mL did not show additional improvement. Thus, the enhancement of wound closure by basic fibroblast growth factor may be caused by the cell proliferative response, rather than by chemotaxis.

Animals↗
PubMed1996

Extraskeletal mesenchymal chondrosarcoma of the labium majus.

Extraskeletal mesenchymal chondrosarcoma is a rare tumor. It has been noted to occur most commonly in muscle and the central nervous system. It has never been reported to occur in the soft tissues of the anogenital region. We report the first such case, occurring in a 40-year-old woman who presented with a 1-year history of a mass originating in the left labium majus. After extensive local resection and lymph node dissection she remains disease free after 40 months follow-up.

Adult↗