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Biomedical subjects

N Maeda

Publications and source records attributed to N Maeda.

At least 685 records · Page 38Linked to original sources

Does social security support for medical care weaken public health programs?

Social security programs for medical care in Latin American countires have long been regareded as rivals to the Ministries of Health. Although they typically cover only a small fraction of the population theoretically served by the Ministries, they often have larger health budgets; on a per beneficiary basis, their expenditures are invariably much higher. Analysis of relative strengths of social security programs (percentage of economically active persons covered and national per capita outlays), in twelve Latin American countries, however, shows them to have correlation (virtually zero) to the strengths of Ministries of Health (percentage national budgets devoted to public health). It appears that both social security and Ministry of Health expenditures correlate in a strongly positive direction with a country's per capita gross domestic product. There is no evidence that stronger social security programs are associated with weaker Ministries of Health.

Health Expenditures↗

Myocardiac changes in experimental renal failure--a light and electron microscopic study.

The experiments we described in this paper demonstrated that the myocardiac lesions without hypertension could be produced by renal failure in rabbits; after this experimental renal failure, increase in blood urea nitrogen and various functional and morphological changes suggestive of heart lesions appeared. The main structural changes in the heart were cellular edema with dilatation of the sarcotubular system, destructive changes of the mitochondria and contractile elements, and coagulative degeneration. These myocardiac lesions are induced by renal failure, and are probably caused by electrolyte imbalance, metabolic disorder, and/or hemodynamic abnormality rather than by hypertensive or toxic factors.

Acute Kidney Injury↗

[Correlation of external cardiac indices with internal parameter of left ventricular function in hypertension and ischemic heart disease (author's transl)].

An indirect and direct estimate of the left ventricular performances were compared in 45 patients with hypertension, arteriosclerotic heart disease and miscellaneous diseases. In results, externally measured LVET, ET/PEP, PEP and a wave ratio correlated well with internally measured myocardial function. Therefore it was concluded that this convenient and atraumatic method was useful as a valid and sensitive measure of myocardial performance.

Adolescent↗

The isolation of an easily reversible post-synaptic toxin from the venom of a sea snake, Laticauda semifasciata.

A weakly neurotoxic component (Ls-III) was isolated by CM-cellulose column chromatography from the venom of a sea snake Laticauda semifasciata. The content of component LsIII was about 10-20% of the venom as determined by u.v. absorption at 280nm. Component LsIII was homogeneous on rechromatography and disc electrophoresis, and its molecular weight was shown to be 7100 by ultracentrifugation and 7300 by sodium dodecyl sulphate-polyacrylamide-gel disc electrophoresis. The isoelectric point of component LsIII was pH7.2. Component LsIII consisted of 66 amino acid residues including 10 half-cystine residues. The LD(50) of component LsIII by intramuscular injection was 1.24mug/g body wt. for mice and 0.45mug/g for baby chicks, which is about eight to ten times less toxic than erabutoxins a, b and c, all of which are contained in the same venom. Experiments with three isolated muscle preparations from different species indicated that component LsIII was a post-synaptically acting toxin, the action of which was easily reversed by washing.

Acetylcholine↗

The primary structure of the toxin Laticauda semifasciata III, a weak and reversibly acting neurotoxin from the venom of a sea snake, Laticauda semifasciata.

A weak and reversibly acting neurotoxic protein of Laticauda semifasciata venom, Laticauda semifasciata III (component LsIII), was sequenced. Component LsIII consists of 66 amino acid residues and has five disulphide bridges, one of which was located between residues 26 and 30. The weak and reversible neurotoxicity of component LsIII is discussed in relation to its structure, which falls between those of the neuro- and cardiotoxins of sea snakes and Elapidae snakes isolated and sequenced so far.

Amino Acid Sequence↗