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Biomedical subjects

N Levy

Publications and source records attributed to N Levy.

At least 127 records · Page 7Linked to original sources

The changing epidemiology of diverticular disease in Israel.

In a retrospective evaluation of 1244 consecutive barium enemas performed at two hospitals over a five-year period (1979 to 1984), colonic diverticula were found in 177 (14.2 percent). The prevalence among the Ashkenazi Jews was 19.7 percent, among the Sephardi and Oriental Jews, 16 percent, and among the Arabs, 9.5 percent. Comparing these figures with the results of a similar study performed ten years ago, it becomes obvious that the prevalence of diverticular disease in the Ashkenazi group remained the same, while there was a three-fold increase among Sephardi and Oriental Jews, and a seven-fold increase among Arabs. It is postulated that, in less than one generation, diverticular disease will be equally frequent among all ethnic groups in Israel.

Adolescent↗

The Groll-Hirschowitz syndrome.

Two sisters showed a similar disorder with cachexia, sensory deafness, and upper gastrointestinal abnormalities. The family pedigree suggests autosomal recessive inheritance of the disorder. Demyelinization demonstrated by a peripheral nerve biopsy may explain the basis for the manifestations. Only one family with this unique syndrome has been reported in the literature. The term "The Groll-Hirschowitz Syndrome" has been suggested, named after the two physicians who first described this condition.

Adult↗

Cytofluorographic analysis of lymph nodes from patients with the persistent generalized lymphadenopathy (PGL) syndrome.

Significant progress has been made in defining the clinical features, immunologic defects, and etiologic agent(s) of the acquired immune deficiency syndrome (AIDS) and its related disorders, but much remains to be learned about the natural history and pathogenesis of these diseases. Most immunologic studies to date have used peripheral blood lymphocytes or sections of lymph nodes for analysis. In this study lymph node cell suspensions from 37 patients with the persistent generalized lymphadenopathy syndrome (PGL) were phenotyped with monoclonal antibodies and flow cytometry and the results were compared with nodal suspensions from 49 patients with other types of reactive hyperplasia. Several significant differences were noted in the PGL nodes, including a decreased but not reversed T4/T8 ratio (1.44 vs 3.0, P less than 0.0001), a decreased percentage of T4+ lymphocytes, an elevation of T8+ lymphocytes, and increased numbers of activated lymphocytes. The shift in the T4/T8 ratio in PGL nodal suspensions was due primarily to a decrease in T4+ lymphocytes rather than in increase in T8+ cells. The possible specificity of these findings for infection by the AIDS agent and their potential prognostic utility are discussed.

Acquired Immunodeficiency Syndrome↗

Accuracy of endoscopy in the diagnosis of inflamed gastric and duodenal mucosa.

Two hundred twenty-three patients underwent upper gastrointestinal endoscopy and biopsy. Correlation of endoscopic and histological findings revealed that a normal gastric and duodenal mucosa could be correctly diagnosed endoscopically in about 80 and 88% of cases, respectively. Duodenitis was diagnosed correctly in 83% of cases; however, the correct endoscopic recognition of gastritis was achieved in only about 50% of the cases. Better results were achieved in "anastomitis," in which the endoscopic diagnosis was correct in 90% of cases. This study supports the view that endoscopy alone should not be relied upon in the diagnosis of gastritis or duodenitis.

Atrophy↗

In vivo and in vitro testing of gloves for protection against UV-curable acrylate resin systems.

In vitro data demonstrated that the permeation of a UV-curable urethane acrylate resin system through glove materials was greatest for latex and neoprene gloves and less for two nitrile gloves. Permeation in vitro for the resin system took longer than 480 min. Individual components of the resin permeated faster when tested separately than when in the formulated system. In vivo 48-h patch test data suggested that neither nitrile glove would be adequate for worker protection, but the in vivo test exaggerated the duration of contact between resin, glove, and skin. Both nitrile gloves provide adequate protection under use conditions, provided the gloves were not re-used within 8 h.

Acrylates↗

Reactive lymphoid hyperplasia with single class (monoclonal) surface immunoglobulin.

Lymphoid tissues from 12 patients were diagnosed as reactive lymphoid hyperplasia, but surface immunoglobulin studies revealed monoclonal (single class) immunoglobulin staining patterns. Infectious, autoimmune, and immunodeficient conditions were diagnosed on the basis of histology and clinical features. Such surface immunoglobulin restriction has been used as an indicator of a neoplastic lymphoid proliferation, but the cases of these patients, in whom the histologic diagnosis was benign, emphasize the importance of a multiparameter approach to diagnosis. Although at the time of this report none of the patients still available to follow-up study have developed known lymphoid neoplasms, the possibility that monoclonal SIg patterns are a harbinger of neoplastic disease makes continuing follow-up of such patients important.

Adolescent↗

Spinal cord glioma following irradiation for Hodgkin's disease.

A 21-year-old patient, after radiation therapy to the mediastinum for Hodgkin's disease, died six years later of a spinal cord glioma, believed to be caused by irradiation therapy. That the x-ray therapy provoked neoplastic changes seems likely, although it could be coincidental.

Adult↗

Serum lysozyme activity in inflammatory bowel disease.

Serum lysozyme activity was determined in the sera of 70 patients with inflammatory bowel disease by the lysoplate method. Serum lysozyme levels were significantly elevated only in patients with Crohn's disease of the small bowel. Patients with either granulomatous or ulcerative colitis had serum lysozyme values not different from normals, irrespective of activity of their disease.

Adult↗

Splenosis simulating an intramural gastric mass.

A case of splenosis simulating a fundal intramural gastric mass in a patient with leiomyoblastoma is presented. Splenosis should be included in the list of differential possibilities of intramural or exogastric lesions when previous splenectomy has been performed, either secondary to trauma or surgical laceration of the splenic capsule. The absence of the spleen makes splenosis a diagnostic consideration.

Diagnosis, Differential↗