Biomedical subjects

N L Senianskaia

Publications and source records attributed to N L Senianskaia.

3 recordsLinked to original sources

PubMed1985

[Electron microscopic study of postmortem fibrinolysis].

The blood of patients dying suddenly possess the capacity of coagulation in vitro and then of transforming spontaneously into a liquid state, this being explained by the post-mortem fibrinolysis. Electron microscopic examination of this process allowed one to follow the dynamics of structural changes in the postmortem coagulates in the course of their spontaneous lysis and retraction in vitro. It is established that the main morphological criterion of the coagulates lysis is the destruction of fibrin fibrils and their degradation into the globular particles. Polynuclear leucocytes play an important role in the lysis of coagulates; they not only phagocytized the aggregated platelets and fibrin but seemed to release specific fibrinolytic factors into the coagulates. In the coagulates undergoing retraction, as distinct from those undergoing lysis, the destruction of platelet aggregates, strengthening and densening of the fibrin network are noted.

Blood Platelets↗

PubMed1982

[Morphology of thrombolysis as affected by a plasmakinase preparation].

The effect of a new thrombolytic preparation, plasmakinase, on experimental coagulates and thrombi was studied morphologically. Histological and electron microscopic studies revealed changes in the structure of fibrin fibers in the form of separation of fibers into individual protofibrils and subsequent degradation into globular particles. There were disorders in the fibrin association with blood cells, washing out of partially hemolyzed red blood cells into the bloodstream, decrease in the size of thrombi and restoration of the vessel lumen.

Animals↗

PubMed1982

[Bacterial shock].

Bacterial shock (BS) is a complication of infectious and suppurative surgical diseases caused mainly by gram-negative bacterial flora. The leading role in the pathogenesis of BS belongs to intoxication of the host by bacterial endotoxins resorbed from the primary focus, by products of protein disintegration, as well as hyperproduction of biologically active substances in the patient. The clinico-anatomical variants of BS are adequate to the quantity and quality of toxins resorbed from the primary focus. An accurate pathoanatomical diagnosis of BS is mandatory for its profound investigation. This diagnosis is possible on the basis of a careful clinico-anatomical analysis with due consideration of the morphological criteria of hemocoagulation and peripheral hemodynamics disorders (the liquid state of cadaver blood, disseminated intravascular coagulation, blood sequestration in some bassins, and intraorgan shunt of the bloodstream).

Abortion, Illegal↗