Search PubMed⌕ Search

Biomedical subjects

N Kuriya

Publications and source records attributed to N Kuriya.

52 records · Page 3Linked to original sources
PubMed1985

Prognostic factors in children with acute lymphoblastic leukemia. Part II: Multivariate analysis. Children's Cancer and Leukemia Study Group.

The pretreatment characteristics of 158 children with previously untreated acute lymphoblastic leukemia diagnosed April 1972 to June 1978 were analyzed for their ability to predict prognosis. The children were treated according to therapeutic protocols 721, 745 and 765, by members of the Japanese Children's Cancer and Leukemia Study Group. Multivariate analysis was performed to determined the relationship between the characteristics and duration of survival of the patients. The following characteristics were analyzed: initial white blood cell (WBC) count, age at diagnosis, initial hemoglobin level, initial platelet count, sex, organomegaly, and treatment regimen that was provided. By using multivariate techniques, factors were found which the independently and significantly predict the length of survival. These factors were initial WBC count (r0 = 0.2908), age at diagnosis (r0 = 0.2982), and treatment regimen (r0 = 0.2488). Using the major prognostic factors of age at diagnosis and initial WBC count, a formula to predict the survival time was established. According to the initial WBC count and age at diagnosis, we classified all cases of childhood ALL as standard risk and high risk.

Adolescent↗
PubMed1985

Prognostic factors in children with acute lymphoblastic leukemia. Part I: Univariate analysis. Children's Cancer and Leukemia Study Group.

The pretreatment characteristics of 158 children with previously untreated acute lymphoblastic leukemia diagnosed April 1972 to June 1978 were analyzed for their ability to predict prognosis. The children were treated according to therapeutic protocols 721, 745 and 765, by members of the Japanese Children's Cancer and Leukemia Study Group. A univariate analysis was performed to determine the relationship between the characteristics and the duration of the patients' survival. The following characteristics were analyzed: initial white blood cell (WBC) count, age at diagnosis, initial hemoglobin level, initial platelet count, sex, organomegaly, and treatment regimen that was provided. Favorable prognosis was exhibited only by those patients with initial WBC counts of less than 50,000/mm3, with age at onset between 2 and 6 years, without splenomegaly, and with hemoglobin levels between 5 and 10 g/dl. The most significant contributions among the various individual prognostic factors were initial WBC count (p less than 0.001) and the age at diagnosis (p less than 0.01).

Adolescent↗
PubMed1985

Radioimmunoassay of human plasma apolipoprotein A-1: pretreatment of plasma with guanidine hydrochloride.

A sensitive and specific double antibody radioimmunoassay for apolipoprotein A-1 was first reported by Schonfeld and Pfleger (1). Their procedure required delipidation of the serum since direct radioimmunoassay of apolipoprotein A-1 in untreated sera resulted in much lower values than those obtained from the corresponding delipidated samples. In an attempt to find a rapid and simple procedure for radioimmunoassay of apolipoprotein A-1 without using organic solvents, the serum was subjected to various physical and chemical treatments which disrupt or alter high density lipoproteins (HDL). Heating at 52 C for 3 h and the treatments with 0.1% Triton X-100, 0.05 M sodium dodecyl sulfate (SDS), and 8 M urea resulted in an increased immunoreactivity of apolipoprotein A-1; the reactivity, however, was much lower than that obtained from delipidated samples. Treatment with 6 M guanidine hydrochloride for 3 h at 37 C prior to radioimmunoassay resulted in a maximal increase of apolipoprotein A-1 immunoreactivity comparable to that obtained with delipidated samples. This pretreatment permits a large number of samples to be assayed with complete recovery of apolipoprotein A-1.

Apolipoprotein A-I↗
PubMed1983

Evaluation of tonsillectomy as a treatment for pustulosis palmaris et plantaris.

One hundred and twenty-four cases of pustulosis palmaris et plantaris (PPP) were studied by questionnaire survey to evaluate the effectiveness of tonsillectomy as treatment. We found that tonsillectomy as a method of treatment for PPP showed a significantly high rate of cure, against which other methods of treatment, e.g. corticosteroid therapy, PUVA therapy and so on, were compared. The examination, by means of Kaplan-Meier's method, showed a 59.2% cure rate for patients one year after tonsillectomy and 71.8% 2 years after the operation. When patients are older than 60 years, the prognosis is good, regardless of the method of treatment.

Adolescent↗
PubMed1978

Biofeedback modification of frontal EMG in normal subjects.

We carried out a controlled study on the voluntary control of the frontalis muscle by biofeedback procedures employing 20 normal subjects. Subjects were randomly divided into two groups of 10: (1) the biofeedback group and (2) the control group. Each of the two groups received five training sessions of about 40 minutes' duration each on different days. The results obtained are as follows: (1) In the biofeedback group, mean EMG levels decreased progressively and markedly from 2. 16 muVp-p min the first session to 1.54 muVp-p min in the last session. On the contrary, the control group did not show constant decreases in EMG levels over sessions. (2) The changes in the heart rate did not correlate with the changes in EMG activity. (3) The changes in the respiratory rate correlated with the changes in EMG activity.

Adult↗
PubMedDate not supplied

Fragile X syndrome in Japanese patients with infantile autism.

Forty-seven patients (39 boys and 8 girls) with infantile autism whose clinical symptoms had matched the diagnostic criteria of DSM III were studied cytogenetically for the occurrence of fragile X [fra(X)] syndrome. The existence of fra(X) chromosome in these patients was screened first by culturing peripheral blood lymphocytes in a medium in which folic acid was absent; the fra(X) chromosome then was confirmed by reculturing in another medium to which 5-fluoro-2'-deoxyuridine was added for the last 24 hours of culture. Fra(X) chromosome was found in 2 of 39 male patients, but in none of the female patients; the 2 patients are siblings. Thus, fra(X) syndrome occurs in 2.6% (1/38) in this study population of male autistic children. The frequencies of fra(X) expression in the older brother with mild mental retardation, in the more severely retarded younger brother, and in their mother were 3-5%, 17-20%, and 9-3%, respectively. Of the two methods used in the present study, the method employing 5-fluoro-2'-deoxyuridine tended to be more sensitive to fra(X) chromosome detection, especially for a suspected carrier.

Adolescent↗
PubMedDate not supplied

Effect of ischemia on peripheral nerve function in diabetes mellitus.

In Japan, diabetic patients are known to be able to sit on the floor for a prolonged time because of mildness or absence of ischemic paresthesia. In order to investigate this resistance to ischemia quantitatively, the mixed nerve function of the median nerve was studied during 30 min of ischemia using surface electrodes in 60 diabetic patients and 15 normal subjects. In studies of 33 unequivocal diabetics, potential amplitudes decreased during ischemia more slowly than in the controls, and at 15 min of ischemia, potential amplitudes were greater in all 33 diabetics than in the 15 normal subjects. The relationship between the resistance to ischemia and various aspects of diabetes was studied further in the 60 diabetics including the 33 aforementioned patients. Resistance to ischemia was found in almost all diabetics and no significant correlation was shown with values for fasting blood glucose and HbA1c, other diabetic complications or duration of diabetes. However, values for potential amplitudes declined to the normal range in seven of 18 patients after strict glucose control. These results suggest that resistance to ischemia is the earliest manifestation of peripheral nerve dysfunction and is different from classical diabetic neuropathy. Furthermore, the method employed in this study is simple, noninvasive and clinically very useful.

Action Potentials↗
PubMedDate not supplied

[Clinical testing of intra-articularly injected glycosaminoglycan polysulfate in gonarthrosis ( a controlled multicenter double-blind study)].

In order to evaluate the clinical efficacy of glycosaminoglycan polysulfate (GAGPS) in osteoarthrosis of the knee, a double blind comparative study was carried out at 26 orthopaedic clinics throughout Japan. A total of 120 patients was divided into two groups; one group was treated with 1 mg GAGPS (control group) and the other with 50 mg GAGPS (drug group). Five or more injections (average: 9.3) were given at about weekly intervals (average: 8.2 days). The score derived from the knee scoring scale improved significantly in both groups, either after the 5th and the 10th injections. The score that had improved after the 10th injection in drug group was statistically superior compared to the control (p less than 0.05), however, the difference in the two groups after the 5th injection did not reach a level of any statistical significance. Doctors' assessment of the usefulness of the drug based on the balance of effects and side effects was obtained in 71.2% and 41.1% in drug group and control group, respectively. The difference was statistically significant (p less than 0.01). In conclusion, the authors confirmed that the intraarticular injections of 50 mg GAGPS were useful for osteoarthrosis of the knee although the clinical symptoms were improved only gradually following the injections.

Clinical Trials as Topic↗