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Biomedical subjects

N Khrouf

Publications and source records attributed to N Khrouf.

At least 37 records · Page 2Linked to original sources
PubMed1991

[Genetic study of congenital afibrinogenemia. Review of 12 cases].

Twelve cases of congenital afibrinogenemia in 11 families are reported. A family study was performed in six cases. The parents were genetically related in 8 of the 11 families. In half the cases another sibling had the disease. In every case the direct ascendants were unaffected. On the basis of results of plasma fibrinogen assays, "unprotected" heterozygotes with no more than 2.5 g/l fibrinogen and "protected" heterozygotes with normal fibrinogen levels were differentiated. Identification of "unprotected" heterozygotes is essential for genetic counselling. The reason for this variable phenotypic expression of congenital afibrinogenemia is unclear.

Afibrinogenemia↗
PubMed1986

Malformations in 10,000 consecutive births in Tunis.

Malformations were assessed in 10,000 consecutively born infants, dead or alive, at the Wassila Bourgiba Maternity Hospital in Tunis. The medical and social history including the rate of consanguinity was studied in the malformed group as well as in a control group of 229 infants. Three hundred and ninety-six infants were malformed; 248 had major malformations and 148 had minor ones. Thirteen per cent of the stillborn were malformed compared to 3.7% of the liveborn. The rates of most specific malformations were comparable to those in other studies but a relatively high rate of neural tube defects, 2.2/1000, can be noted. There is a significant overrepresentation of consanguinity (65%) in parents of non syndromic multi-malformed infants.

Abnormalities, Multiple↗
PubMed1983

[Twin pregnancies: incidence, fetal development and perinatal mortality].

The authors study 233 pairs of twins in a big maternity of Tunis, they analyse the frequency, the intra-uterine growth and the perinatal mortality. The frequency of twinning was 1.56%, the occurrence of preterm delivery was 45.92% and foetal hypotrophy was observed in 9.84% of the cases. The perinatal mortality rate was 143.77%: still born = 55.79% and neonatal deaths = 87.98%; the ratio of still born to neonatal deaths was 1.6. 29.3% of the neonatal twin deaths were due to hyaline membrane disease, 24.5% to immaturity, 14.6% to perinatal asphyxia and 12.4% to infection. The authors compare their findings to other studies on twin pregnancies.

Female↗
PubMed1983

[Fetal macrosomia and the study of risk factors in maternal diabetes].

The authors report the results of a study performed in 142 women who gave birth to overgrown neonates. Among them, the incidence of diabetes was high: 7.75%. Older maternal age, maternal obesity and the former birth of large infants were also found to be risk factors for fetal overgrowth.

Adult↗
PubMed1981

[Low birth-weight neonates in Tunisia (author's transl)].

From a prospective analysis performed in a maternity-hospital in Tunis, incidence, characteristic features and etiologic factors responsible for birth-weight below 2,5000 g have been studied. Incidence of low birth-weight is accepted as an indicator of the level of health care in a country; this incidence, established from 6,028 living births was 7.2%, similar to that in developed countries. On the contrary, intra-uterine growth retardation rates of 69.6% and prematures rates of 30.4% are closer to those in developing countries. Altogether, anomalies of height and of the height/head circumference ratio were present in 36 children only and, in 12 out the these, abnormalities of the placenta or membranes or evidence of fetal disease were found. A factor responsible for low birth weight was found in 182 neonates: previous severe disease in the mother (7.7%), toxemia (9.4%) twin pregnancy (22.41%), fetal pathology (3.5%) and pathology of the placenta and membranes (4.6%).

Body Height↗
PubMedDate not supplied

[Tracheal atresia. A case report].

The tracheal agenesis is a rare malformation of the respiratory tract. It must be suspected in any new born with respiratory distress, absence of crying, and difficulty or impossibility of intubation. Since the initial case report by Payne in 1900, 87 cases have been reported in the literature. The authors report one case of tracheal agenesis out of 2500 autopsy realised in the laboratory.

Autopsy↗
PubMedDate not supplied

[Antenatal diagnosis and contribution of fetopathologic examination in the management of omphalocele].

The omphalocele is an average coelosomie, frequency of which is estimated at 1/5000 births. We confront diagnosis antenatal with the exam foetopathologic in purpose of 41 cases of omphalocele brought together over a period going from January 1, 1991 till December, 2000 in the unity of foetopathologie from the CMNT. The frequency of omphaloceles is 4.88% of the children malformed and of 1.64% of the set (group) of the performed an autopsy children. An association malformative was found in 85.4% of cases and a karyotype typical aberration trisomie 13.18 and 21 was identified in 17% of cases. The preview of the children bearers of this deformation is especially bound (connected) to the existence and to the gravity of associated abnormalities. The omphalocele required a multidisciplinary making coverage intervernir obstetriciens, néonatologistes, surgeons pediatre and foetopathologistes.

Abnormalities, Multiple↗
PubMedDate not supplied

Iron stocks and risk of anemia in twins.

This study aims to compare the risk of anemia by iron deficiency in mothers and infants of twin and single pregnancy. It concerned 33 couples of twins and 31 control, all 97 being term newborns. At birth, ferritinemia is significantly lower in twins, and reticulocytes count is significantly higher; their mothers have a significantly lower hemoglobin level and higher reticulocytes percentage and count. At 3 and 6 months, hemoglobin level and mean corpuscular hemoglobin are significantly lower in twins, as at 6 months ferritinemia is significantly lower in twins. Iron stocks constituted in utero are significantly lower in twin pregnancy, and this study support the early preventive iron treatment in twins.

Anemia, Hypochromic↗