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Biomedical subjects

N Kanemoto

Publications and source records attributed to N Kanemoto.

At least 73 records · Page 4Linked to original sources

A case with pseudo-scimitar syndrome: "scimitar sign" with normal pulmonary venous drainage.

The case reported here showed a radiological appearance of hypoplasia of the right lung, dextroposition of the heart, and a curved vascular shadow in the right lower lung field known as a scimitar sign. However, a computed tomography of the chest showed this abnormal vascular shadow draining into the left atrium (pseudo-scimitar sign). Therefore, in patients with a radiological appearance of the scimitar syndrome, computed tomography of the chest should be indicated to rule out the pseudo-scimitar sign.

Cardiac Catheterization↗

A case of pheochromocytoma with transient hyperinsulinemia and reactive hypoglycemia.

Hyperglycemia is a common symptom of pheochromocytoma. In the present paper, a 57-year-old man with transient hyperinsulinemia and reactive hypoglycemia is reported. His blood pressure was 100/50 mmHg. Following 75 g oral glucose intake, his blood sugar and insulin levels were 150 mg/dl and 15 mu Iu/ml at 0 min, 373 mg/dl and 757 mu Iu/ml at 60 min and 34 mg/dl and greater than 1,000 mu Iu/ml at 120 min, respectively. High plasma epinephrine and norepinephrine levels and histological findings of adrenal tumor confirmed the diagnosis of pheochromocytoma. Pheochromocytoma should be considered as one of the diseases which account for unexplained transient hyperinsulinemia with reactive hypoglycemia.

Adrenal Gland Neoplasms↗

Electrocardiogram in primary pulmonary hypertension--with special reference to prognosis.

The electrocardiogram (ECG) in patients with primary pulmonary hypertension who died suddenly (Group II, 12 patients) and those who died of right heart failure (Group III, 19 patients) were compared with those of long-term survivors (Group I, 10 patients). In P waves, AP had a tendency to deviate more to the right in Groups II and III than in Group I. P terminal force in lead V1 tended to show a greater absolute value, and the amplitude of P waves in lead II were higher in Groups II and III than in Group I. The AQRS in Groups II and III deviated significantly much more to the right than in Group I. In lead V1, S waves had a tendency to be deeper and the R/S ratio greater in Groups II and III than in Group I. In leads V5 and V6, R waves and the R/S ratio significantly lower in Groups II and III than in Group I. S waves in lead V6 tended to be deeper in Groups II and III than in Group I. In the ECG patterns, S1O3, inverted T waves in leads II, III and a VF and qR patterns in lead V1 tended to appear more often in Groups II and III than in Group I. In Groups II and III, there was T wave inversion beyond V3 to the left chest leads and significant differences between Groups II and III, and Group I.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗

[Evolution of dilated cardiomyopathy from hypertrophic obstructive cardiomyopathy: a case report].

A 20-year-old woman whose echocardiograms showed a rare evolution from hypertrophic to dilated cardiomyopathy during a nine year observation period is described. This patient was initially diagnosed as having hypertrophic obstructive cardiomyopathy (HOCM) at the age of 12 years. Her echocardiogram showed marked thickening of the interventricular septum (IVS) and left ventricular posterior wall (LVPW), asymmetric septal hypertrophy (ASH) and systolic anterior motion of the mitral valve (SAM). Chest radiography revealed a prominent left ventricular border and a cardiothoracic ratio of 0.52. At 18 years of age she experienced onset of palpitation during the 16th week of pregnancy. Her echocardiogram recorded in June 1980 revealed a thickened IVS and LVPW with resolution of the SAM and of the narrow cavity. At 20 years of age she became pregnant again and was admitted to our hospital for the third time at 24 weeks gestation. On admission her blood pressure was 122/60 and her pulse was 56, and moist rales were audible over both lung fields. Peripheral edema was noted. Chest radiography revealed moderate cardiomegaly, a cardiothoracic ratio of 0.66, and congestion of the pulmonary vasculature. An echocardiogram showed thinning of the IVS and LVPW with hypokinesis and dilatation of the cavity compatible with dilated cardiomyopathy (DCM). She delivered a boy on July 15th 1982 at 32 weeks gestation following which she developed marked congestive heart failure. She expired one month later. A chest radiograph made one day before death revealed marked cardiomegaly, a cardiothoracic ratio of 0.76, prominent pulmonary vasculature and a pleural effusion. Autopsy was refused; therefore the terminal DCM-like features were not clarified pathologically. However, the slow progression from HOCM to HCM during eight years and then rapid progression from HCM to DCM during four months was most impressive.

Adult↗

A case of normotensive pheochromocytoma masquerading as a dilated cardiomyopathy.

A case of right adrenal pheochromocytoma masquerading as a dilated cardiomyopathy is described. This patient was normotensive throughout 8 years of observation. Hyperglycemia and an abnormal glucose tolerance test were a clue to the diagnosis which was confirmed by the findings of increased plasma and urinary epinephrine and norepinephrine values. In patients with dilated cardiomyopathy the possibility of a pheochromocytoma should be considered.

Adrenal Gland Neoplasms↗

Percutaneous transluminal coronary angioplasty.

Percutaneous transluminal coronary angioplasty (PTCA) is a nonoperative mechanical dilatation of atherosclerotic coronary artery stenosis by a balloon-tipped dilating catheter system. This method can effectively reduce highly stenotic coronary lesions and provide early recovery of ischemic but viable myocardium. The technique of transluminal angioplasty was originally devised by Dotter and Judkins (1964) for the treatment of atherosclerotic stenoses of peripheral arteries and was introduced in modified form by Grüntzig for the treatment of coronary artery disease in 1977. Recently this procedure seems to have been accepted world wide as one of the potential therapeutic modalities comparable to aorto-coronary bypass surgery in selected patients with angina pectoris. In this paper, the author introduced the present status of PTCA including his own data.

Aged↗

A case of idiopathic sustained ventricular tachycardia of about 70 days' duration.

A 29-year-old woman with idiopathic sustained ventricular tachycardia (VT) of about 70 days' duration who was in congestive heart failure is described. VT showing QRS morphologic pattern of right bundle branch block and left axis deviation during an episode of tachycardia is suggested to make a unique clinical entity; (1) it occurred in young and asymptomatic adults without demonstrable organic heart disease; (2) the VT was inducted and terminated with atrial or ventricular stimulation; and (3) it responded to verapamil.

Adult↗

[Pheochromocytoma with normal blood pressure and dilated cardiomyopathy: a case report].

A rare complication of normotensive pheochromocytoma with dilated cardiomyopathy is described. This 57-year-old man first experienced palpitation eight years ago when his blood pressure, electrocardiogram and chest radiograph were all within normal limits. Five years later he was admitted to another hospital because of palpitation and was diagnosed as having dilated cardiomyopathy on the basis of cardiac catheterization and cardiac muscle biopsy. In December, 1984, he was admitted to our hospital for treatment of congestive heart failure. On admission, his electrocardiogram revealed left atrial overloading, left axis deviation, left ventricular hypertrophy with intraventricular conduction disturbances and frequent premature ventricular contractions. Echocardiography revealed marked biventricular dilatation with severe hypokinesis of the interventricular septum and the posterior wall of the left ventricle, and a B-B' step of the anterior mitral leaflet. Fasting blood sugar was slightly elevated and a 75 g glucose tolerance test was abnormal. An abdominal echogram and abdominal CT revealed a 67 mm diameter mass immediately superior to the right kidney. Blood and urine catecholamine levels were significantly increased. He was diagnosed as having a pheochromocytoma. Interestingly, he had been normotensive during the eight years until his fatal outcome. He died of congestive heart failure. Needle necropsy findings of the adrenal revealed pheochromocytoma, and those of the cardiac muscle revealed enlarged muscle cells and mild fibrosis.

Adrenal Gland Neoplasms↗

Improvement of regional myocardial perfusion following percutaneous transluminal coronary angioplasty in patients with coronary artery disease.

The effect of percutaneous transluminal coronary angioplasty (PTCA) upon regional myocardial perfusion (RMP) was studied in 49 patients (Group I) using T1-201 myocardial scintigraphy (TMS) after exercise. Ten patients with unsuccessful PTCA (Group II) were tested for the reproducibility of measurements and for comparison. All patients had arteriographically documented coronary artery stenosis (greater than or equal to 70%) in at least one major coronary vessel. In group I, average coronary stenosis was 84.0 +/- 7.8% (mean +/- SD) before PTCA and 38.8 +/- 11.9% after PTCA (p less than 0.001). TMS was performed 3 days before and 4 days after PTCA using an arm-assisted step test. Myocardial perfusion images were obtained 5-10 min, 1 hour and 3-4 hours following the injection of T1-201 in anterior, LAO 45 degrees and LAO 80 degrees views. The T1-201 myocardial scintigram was interpreted by the authors. Each scintigram (anterior, LAO 45 degrees and LAO 80 degrees) was divided into 5 roughly equal segments. The perfusion of each segment was graded from 0 (no perfusion) to 3 (normal perfusion). Thus, for each patient a "total myocardial perfusion index (TMPI)" could be calculated, with a score of 45 indicating normal RMP. The total number of involved segments (TNIS) was also calculated as a sum of abnormally perfused segments. In group II, the reproducibility of both TMPI and TNIS was satisfactory (r = 0.97 and r = 0.93, each p less than 0.001). In group I, TMPI before PTCA was 37.8 +/- 4.8 at 5-10 min, 39.8 +/- 4.4 at 1 hr and 40.8 +/- 4.2 at 3-4 hrs. These values increased significantly after PTCA to 41.3 +/- 4.0, 41.9 +/- 4.1 and 42.0 +/- 4.0, respectively (each p less than 0.001). TNIS also decreased significantly following PTCA. Group I patients were further divided into 2 groups: patients with and without previous myocardial infarction. Although patients with previous myocardial infarction had significantly lower TMPI values and greater TNIS values than without previous myocardial infarction, these parameters improved significantly after PTCA. Therefore, we conclude that PTCA can improve exercise induced regional myocardial ischemia, if luminal diameter is dilated by more than 20%. Patients with previous myocardial infarction and persisting angina are also considered to be candidates for PTCA.

Adult↗

[Evaluation of left ventricular function by digital subtraction angiography: effect of dose and administration mode of contrast medium, and comparison with direct ventriculography].

Effects of contrast medium doses on left ventriculographic images using intravenous digital subtraction angiography (IVDSA-LVG) were assessed. The validity of IVDSA-LVG in evaluating ejection fraction (EF) and left ventricular regional wall motion was determined by comparison with conventional left ventriculography using direct injection (direct LVG). The advantages of left ventriculography using intraarterial subtraction angiography (IADSA-LVG) performed by injecting small doses of contrast media directly into the left ventricle were stressed. To assess the effects of doses of contrast media on IVDSA-LVG, 10, 20, and 30 ml Urografin-76 were injected into the superior vena cava in 16 patients, and the resulting images were compared in each patient. With only 10 ml contrast medium, left ventricular opacification was fairly good, and regional wall motion was evaluated in many cases, but 30 ml were needed to calculate ventricular volume and EF. To determine the validity of IVDSA-LVG in evaluating EF and regional wall motion, we compared IVDSA-LVG using 30 ml of contrast medium with direct LVG in 18 patients. There was a good correlation between the two methods in determining EF (r = 0.877), and 90% of the interpretations of regional wall motion were in agreement by the two methods. IVDSA-LVG was useful and accurate in evaluating EF and regional wall motion of the left ventricle. IADSA-LVG was performed for five patients, and good quality images were obtained in many cases, even with relatively small doses (10 ml) of contrast media. These results suggested that this method may be used in cases with impaired LV function, to avoid hemodynamic derangement induced by conventional direct LVG using large doses of contrast medium.

Adult↗