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Biomedical subjects

N K Shinton

Publications and source records attributed to N K Shinton.

At least 19 recordsLinked to original sources
PubMed1993

Effect of the choice of WHO International Reference Preparation for thromboplastin on International Normalised Ratios.

AIMS: To compare the International Normalised Ratio (INR) obtained directly with the two types of WHO plain International Reference Preparation for thromboplastin in patients treated with coumarin. METHODS: Prothrombin times were performed in parallel at four centres using WHO human plain IRP (BCT/253) and rabbit plain IRP (RBT/79). Sixty patients and 20 normal controls were tested at each centre. Differences in INR among the centres were assessed by one factor, analysis of variance. The bias for each centre was assessed by the t test. RESULTS: At all four centres higher INRs were consistently found with the rabbit plain reagent. Two of the centres showed significantly greater bias. CONCLUSIONS: There was a small but significant difference in INR results obtained directly with these two reference reagents at all four centres (mean 7.35%). This in part may result from the different responsiveness of the two IRP to the coumarin defect or to imprecision of the original ISI calibrations of the two plain WHO IRP. The findings support the adoption of a single master IRP, in accord with WHO recommendations, which would resolve the present anomalous situation.

Analysis of Variance↗
PubMed1984

Protocol for evaluation of automated blood cell counters. International Committee for Standardization in Haematology (ICSH).

This protocol is proposed for the evaluation of automated blood cell counters to assess the performance, advantages and limitations of such instruments. It is based on the International Committee for Standardization in Haematology (ICSH) 'Protocol for type testing equipment and apparatus used for haematological analysis' (1978a) and the British Committee for Standardization in Haematology 'Guidelines for the evaluation of instruments used in haematology' (Shinton, England & Kennedy, 1982). The document has been prepared by the ICSH Panel on Cytometry after discussion with colleagues. This tentative protocol will be reviewed 1 year after publication, in accordance with the ICSH rules, before it is adopted as a definitive standard.

Blood Cell Count↗
PubMed1983

An evaluation of the Technicon H6000 haematology system.

The Technicon H6000 haematology system combines haemoglobinometry with cell counting including differential counts of leucocytes. Evaluation confirmed it to be safe, precise and free from carry-over of practical significance. Comparability with standard reference methods showed a difference with mean cell volume (MCV) and packed cell volume (PCV) but the haemoglobin, red cell count and mean haemoglobin concentration (MCH) were comparable. Total white cell counts and differential counts were comparable apart from eosinophils and basophils. Platelet counts were higher at both ends of the range. Throughput was confirmed at 90 samples per hour. The system was shown to be cost-effective when taking into consideration staff costs, materials and maintenance but expensive with regard to materials alone.

Autoanalysis↗
PubMed1981

Tentative protocol for the evaluation of coagulometers, based on one-stage prothrombin time.

Information on performance is invaluable to those who have to decide on the choice of an instrument. More interest is being shown in the use of coagulometers. Accordingly, a tentative protocol for the evaluation of coagulometers is presented for discussion. While it is based on the use of one-stage prothrombin time, principles of evaluation are laid down which should make it generally applicable. It is hoped that the tentative protocol will form the basis of a reference protocol and to this end comments are invited from users of coagulometers and suppliers. Comments for publication may be sent to the Editor of Clinical and Laboratory Haematology or to the Secretary of the Working Party.

Blood Coagulation Tests↗
PubMed1979

Draft protocol for testing calibration and quality control material used with automatic blood-counting apparatus.

A large number of commercial preparations are now available for calibrating or checking the stability of automatic blood counters. Most of these preparations are supplied with 'stated' values though the methods for assigning these values are not described in sufficient detail to allow for an adequate assessment of the validity. The Haemocytometry Panel of the British Committee for Standards in Haematology are therefore proposing a draft protocol for testing calibration and quality control materials. Comments on the draft protocol are invited, either as letters to the Editor of Clinical and Laboratory Haematology or in confidence to the Chairman of the Haemocytometry Panel.

Automation↗