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Biomedical subjects

N K Man

Publications and source records attributed to N K Man.

152 records · Page 9Linked to original sources
PubMedDate not supplied

Evaluation of plasma sodium concentration during hemodialysis by computerization of dialysate conductivity.

Kinetics modeling based on sodium mass balance and changes in conductivity at the dialysate outlet compared to that at the dialysate inlet, led to predicting the plasma water conductivity of the blood inlet. Conductivity transducers, with temperature compensation, located at the dialysate inlet and outlet ports of the dialyzer and connected to a conductimeter, were interfaced with a portable computer for data acquisition. In 38 dialysis sessions, a close relationship was found between estimated plasma water conductivity (CdBi) and measured plasma sodium concentration [Na]Bi, according to the formula: CdBi = 0.101[Na]Bi + 0.37 (n = 38; r = 0.922). The study shows that plasma sodium concentration at the dialyzer inlet could be evaluated, with a standard error of +/- 1.5 mEq/L, by continuous measurement of conductivity gradient between dialysate inlet and outlet.

Adult↗
PubMedDate not supplied

Renal biofiltration.

Biofiltration is a hemodiafiltration technique performed with a base-free dialysate and simultaneous infusion in postdilution mode of isotonic bicarbonate solution. This technique has the advantages without the inconveniences of bicarbonate dialysis that result from complicated hardware and the need of frequent trouble shooting. In biofiltration, 1) the sodium dialysate concentration should be monitored according to the patient's body weight gain and to the sodium concentration of infusion fluid to obtain adequate sodium mass balance and 2) plasma bicarbonate is easily controlled because the final plasma bicarbonate concentration depends upon the bicarbonate infusion flow rate. Long-term follow-up evaluation (6-24 months) of 76 patients on a dialysis strategy of 3 hr three times a week from 17 European dialysis centers has shown that biofiltration is a simple and safe alternative to bicarbonate dialysis. It could be the way to fulfill the requirements of short time/high quality dialysis, which seems to be the developing trend of dialysis in the future. These advantages are, however, balanced by the extra cost of high flux dialyzers and infusion fluid.

Bicarbonates↗
PubMedDate not supplied

Kinetics of cisplatin in an anuric patient undergoing hemofiltration dialysis.

After in vitro tests, a tracer dose of cisplatin was administered to an anuric cancer patient. Plasma total platinum levels were monitored as a function of time, as was filterable platinum elimination by hemofiltration dialysis. Based on the derived pharmacokinetic parameters, the patient was later given 50-mg doses of cisplatin, once as a single agent, then four times in combination with doxorubicin, VM-26, and cyclophosphamide. Plasma levels could be fitted by a sum of three exponentials after the infusion was stopped. The mean corresponding half-lives are 30 minutes, 6 hours, and 5 days. Depending on the rate of infusion, plasma peaks ranged between 1.1 micrograms/ml (5.7 X 10(-6) M) and 2.27 micrograms/ml (1.16 X 10(-5) M). During the hemofiltration process immediately following the infusion, the elimination rate was first-order, with a mean half-life of 60 minutes. The mean amount eliminated during the first hemofiltration session was 8% of the dose, decreasing to about 3% on Days 2 and 3. A partial tumor response was observed after two treatment courses, evidenced by the relief of abdominal pain and bowel obstruction episodes and a 50% decrease in peritoneal metastases.

Adult↗