Electrocardiographic monitoring II--ambulatory monitoring.
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Arrhythmias, Cardiac↗
Biomedical subjects
N Jowett
Publications and source records attributed to N Jowett.
A common DNA polymorphism of the low-density lipoprotein (LDL) receptor gene and its use in diagnosis.
A cloned gene probe coding for the low-density lipoprotein (LDL) receptor was used to detect a restriction fragment length polymorphism with the enzyme Pvu II. The frequency of the rare allele is approximately 0.2 both in normal controls and individuals with familial hypercholesterolaemia (FH). About 30% of individuals are heterozygous for the polymorphism, and are potentially informative for family studies and for early diagnosis of FH. This polymorphism was used to follow the inheritance of the LDL receptor gene in two families with FH. In these families, the polymorphism co-segregates with the disease unambiguously, and therefore can be used for early diagnosis.
Alleles↗
DNA polymorphisms flanking the apo A-1 and insulin genes and type III hyperlipidaemia.
Two alleles identified by DNA restriction fragment length polymorphisms around the apo A-1/C-III and insulin genes have been shown to be associated with Type IV and V hyperlipidaemia. We have genotyped 19 patients with Type III hyperlipidaemia to establish whether this association is also found in the disorder. Our data show that these associations are not responsible for the majority of cases of Type III hyperlipidaemia, but cannot exclude the possibility that a small proportion (less than 50%) of cases of Type III are caused by interaction between these alleles and the apolipoprotein E2 phenotype.
Adult↗
Diabetic heart disease.
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Diabetes Complications↗
Pillow fights.
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Equipment and Supplies, Hospital↗