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Biomedical subjects

N Jackson

Publications and source records attributed to N Jackson.

At least 127 records · Page 7Linked to original sources
PubMed1975

The amino acid composition of the oviduct of the folic acid-treated and the folate-deficienct, oestrogen-treated immature domestic fowl.

Two experiments are described in which the effect of folate deficiency on the amino aicd content of the oviduct of oestrogen-treated, folic acid-treated and folate-deficient, immature domestic fowl is investigated. Oviducts from non-oestrogen treated, folic acid-treated and folate deficient birds are also compared. A third experiment was carried out in which the effect of folate deficiency on the amino acid composition of the five oviduct sections was examined. An attempt has been made to explain the differences in oviduct amino acid composition in terms of amino acid metabolism and the degree of structural development of the oviduct. It is concluded that folate is most essential for the response of oviduct tissue to oestrogen stimulation in areas where a specialised secretory function is involved. No direct evidence was obtained to indicate that the function of folate in glycine-serine interconversion or methionine regeneration was significant in the inhibition of oestrogen-stimulated oviduct growth.

Amino Acids↗
PubMed1973

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Canada↗
PubMed1972

Virus-specific ribonucleic acid in cells producing rous sarcoma virus: detection and characterization.

Cells producing Rous sarcoma virus contain virus-specific ribonucleic acid (RNA) which can be identified by hybridization to single-stranded deoxyribonucleic acid (DNA) synthesized with RNA-directed DNA polymerase. Hybridization was detected by either fractionation on hydroxyapatite or hydrolysis with single strand-specific nucleases. Similar results were obtained with both procedures. The hybrids formed between enzymatically synthesized DNA and viral RNA have a high order of thermal stability, with only minor evidence of mismatched nucleotide sequences. Virus-specific RNA is present in both nuclei and cytoplasm of infected cells. This RNA is remarkably heterogeneous in size, including molecules which are probably restricted to the nucleus and which sediment in their native state more rapidly than the viral genome. The nature of the RNA found in cytoplasmic fractions varies from preparation to preparation, but heterogeneous RNA (ca. 4-50S), smaller than the viral genome, is always present in substantial amounts.

Aspergillus↗