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Biomedical subjects

N J Smith

Publications and source records attributed to N J Smith.

At least 73 records · Page 4Linked to original sources
PubMed1985

Stafne's bone cavity: a review of the literature and report of two cases.

This paper reports two cases of Stafne's bone cavity, one of which shows apparent regression over a period of 8 years: an unusual feature that has not previously been reported. A comprehensive review of the literature dealing with this well demarcated mandibular radiolucency of unknown aetiology accompanies these two case reports.

Humans↗
PubMed1984

Thalidomide in severe orogenital ulceration.

Thalidomide was given to 15 patients with severe orogenital ulceration (OGU). 4 patients underwent a double-blind controlled trial with glutethimide as placebo and 11 were treated openly. Treatment with thalidomide produced complete resolution of ulcers in 14 and significant improvement in the remaining patient. No peripheral neuropathies developed. Patients did not respond to glutethimide. Thalidomide is an effective treatment for severe OGU. Adequate contraceptive measures should be taken during treatment.

Adolescent↗
PubMed1984

Bifid mandibular condyle.

Two cases of unilateral bifid mandibular condylar head are reported. A review of the literature showed that only four cases had been reported as occurring in living patients, although another twenty-two cases have been reported in dried skull or cadaver material. A brief discussion of the possible etiology is given.

Adult↗
PubMed1984

Comparability ratios by age: based on deaths of Metropolitan policyholders.

Comparability ratios based on 42,229 deaths of Metropolitan policyholders in 1979 were computed by age between the 8th and 9th revision ICD codes for 72 selected causes of death. Comparability ratios by age are not available elsewhere. Except for accidents and adverse effects, the comparability ratios for the major causes of death at all ages combined were in close agreement with those computed by the National Center for Health Statistics.

Actuarial Analysis↗
PubMed1984

Nutrition and athletic performance.

Athletes have a keen interest in informed nutrition counsel. They recognize that food intakes are important determinants of energy availability and body fitness. For many sports, participation will prompt a general upgrading of dietary practices and nutrition-related well-being. Specific nutrition guidance can prevent abuses and can enhance the performance of the athlete and the team in many sports.

Anemia, Hypochromic↗
PubMed1984

Weight control in the athlete.

Altering body composition either through reducing body fat or increasing muscle mass is a frequent and very important concern of large numbers of young athletes. When efforts to induce these body changes are approached with sound principles of nutrition and training, the resulting changes in body composition can make the desired contribution to health and fitness as well as contributing to increasing the athlete's performance potential. Any attempt to alter body composition must be planned over a significant time period, making it essential to initiate the program several weeks prior to the competing season. Significant increases or decreases in any body tissue component cannot be safely accomplished in a brief period. Supervision by a physician or another legitimate health professional is highly recommended to protect the motivated athlete from the abuses of faddists, quacks, and nutrition charlatans. The proper educational information regarding the ineffectiveness and hazards of drug use by the athlete are also to be dealt with. Having achieved a desired body composition, the athlete will recognize an achieved weight as his or her desired competing weight. Monitoring body weight two or three times weekly during the season will identify any involuntary changes in body weight that, if continued, will inevitably compromise athletic performance.

Adolescent↗
PubMed1983

Renal dysfunction in cadmium smelters: relation to in-vivo liver and kidney cadmium concentrations.

Biochemical indicators of renal dysfunction have been compared with liver and kidney cadmium levels measured by neutron activation analysis in a group of 37 cadmium smelters. Higher than normal concentrations of cadmium in the liver reflect past exposure; they were associated with evidence of renal dysfunction in workers exposed to cadmium for more than 10 years. A small group of 6 workers exposed to cadmium for only a short time (mean = 4.6 years) had high hepatic cadmium concentrations but normal renal function. Longitudinal studies are required to establish the natural history of renal dysfunction following cadmium accumulation in industrial workers.

Cadmium↗
PubMed1983

Alcohol use and iron status in pregnant women.

Iron status, assessed by ferritin (ng/ml), transferrin saturation (%), and hemoglobin (g/100 ml), was examined in a sample of 1398 women from blood samples drawn at their first prenatal visit and in 712 of these women later at their 32-week prenatal visit. Self-reported alcohol use (average ounces of absolute alcohol consumed per day around the time of conception) was not systematically related to iron status. Furthermore, the proportion of iron-depleted or anemic women did not vary according to different levels of alcohol use. An exception is noted in a small group of nine very heavy drinkers, reporting eight or more drinks per day, who, at 32 weeks gestation, had a higher proportion of iron depletion but not anemia. It was concluded that at least in a sample of primarily middle class women receiving good prenatal care, iron depletion and/or anemia probably do not explain the alcohol-related adverse pregnancy outcomes that have been reported previously. Nevertheless, results from several very heavy drinkers suggest that the iron status of pregnant alcoholic women should be investigated further.

Adolescent↗
PubMed1983

Teratogenicity study of ethylene glycol in rats.

Ethylene glycol was administered in the diet to pregnant Fischer 344 rats on days 6 through 15 of gestation. Target dosage levels were 1.0, 0.2, 0.04, and 0.00 g/kg/day. There was no maternal toxicity, embryotoxicity, or increased incidence of malformations in fetuses from doses dams. Positive control dams received 500 mg/kg of hydroxyurea on gestation day 11 and had fetuses with numerous soft tissue and skeletal malformations. Results are interpreted as preliminary indication of lack of teratogenicity of ethylene glycol.

Abnormalities, Drug-Induced↗
PubMed1983

Iron repletion decreases maximal exercise lactate concentrations in female athletes with minimal iron-deficiency anemia.

We studied the effect of 2 weeks of iron therapy on exercise performance and exercise-induced lactate production in trained women athletes: six control subjects with normal parameters of iron status and nine with mild iron-deficiency anemia defined by low Fe/TIBC, ferritin, and minimally decreased Hgb values. Iron therapy improved the abnormal measures of iron status and low Hgb in the second group to normal. Exercise performance in a progressive work-exercise protocol on a bicycle ergometer to exhaustion was unchanged after iron therapy in both groups; however, blood lactate levels at maximum exercise in the iron-deficient group decreased significantly from 10.3 +/- 0.6 mmol/L before therapy to 8.42 +/- 0.7 after therapy (p less than 0.03). The control subjects did not significantly alter lactate levels after maximal exercise on iron compared to placebo: 8.3 +/- 0.8 mmol/L vs. 8.5 +/- 0.7. Although there was not a significant difference in maximum exercise performance after iron therapy, these data support animal experiments implying that iron may play a role in oxidative metabolism and that minimal decreases in Hgb may impair arterial oxygen content enough to affect aerobic metabolism. In addition, these findings may have important implications for competitive women athletes in whom mild iron deficiency may go unnoticed.

Acidosis↗
PubMed1982

Agricultural research and Third World food production.

By the close of this century the world may have to feed as many as 2 billion additional people. Most of them will be born in developing countries, especially in marginal lands ill-suited for food production. This article focuses on efforts by the International Agricultural Research Centers to increase food production in the Third World and addresses the social and ecological issues raised by the introduction of high-yielding varieties into fertile Third World lands and describe how varieties are being tailored for introduction into marginal areas.

Agriculture↗