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Biomedical subjects

N J Dudley

Publications and source records attributed to N J Dudley.

33 records · Page 2Linked to original sources
PubMed1992

The influence of age on policies for admission and thrombolysis in coronary care units in the United Kingdom.

Age is an important factor influencing survival following an acute myocardial infarction. In clinical practice many elderly patients are neither admitted to coronary care nor receive thrombolytic therapy. A postal questionnaire was sent to all 175 consultants in charge of coronary care units in the United Kingdom to determine whether age-related policies are being operated which are limiting the access of elderly patients to life-saving interventions. One hundred and thirty-four questionnaires (77%) were returned. One-fifth of coronary care units operate an age-related admission policy, and two-fifths operate an age-related thrombolysis policy. The age limits used by many of these units are likely to exclude large numbers of patients who could benefit from cardiac monitoring and resuscitation as well as thrombolytic treatment. The abolition of age-related policies would help to ensure that thrombolysis is readily available to the group of patients most likely to benefit from it.

Aged↗
PubMed1992

The role of 99Tcm-HMPAO white cell imaging in suspected orthopaedic infection.

Accurate diagnosis is essential for the effective management of suspected bone infection. Current imaging techniques have had limited success and further work is required. Although white cell labelling techniques have been available for many years the radiopharmaceuticals employed have disadvantages, particularly in their availability and suitability for imaging. These problems have been overcome by the use of 99Tcm-HMPAO as an in vitro leukocyte labelling agent. The aims of this study were to assess retrospectively its role and accuracy in imaging orthopaedic infection and to compare the results with three-phase bone imaging. 30 patients with suspected bone infection underwent three-phase methylene diphosphonate (MDP) bone imaging and labelled leukocyte imaging on separate occasions. 16 bone scans were positive for infection, of which 14 were subsequently confirmed, and there were no false negatives. There were no false positive white cell studies and only one infection was not identified. 99Tcm-HMPAO white cell imaging has been shown to be an accurate technique for the diagnosis of bone infection but should be performed only following a positive finding on three-phase bone scanning, since the latter is highly sensitive but significantly less expensive, making it a more appropriate screening procedure.

Adolescent↗
PubMed1990

Aids for visual impairment.

This article provides only a flavour of the type and range of aids available to the visually impaired person. Many other aids for leisure, learning, and daily living are illustrated in the RNIB equipment and games catalogue.

Adolescent↗
PubMed1990

Estimated fetal weight in the detection of the small-for-menstrual-age fetus.

The purpose of this study was to assess the value of calculated fetal weight in the detection of the small-for-menstrual-age fetus. An ultrasound screening scan was performed on 1624 singleton pregnancies at 30 weeks to 36 weeks, menstrual age. Head, abdomen, and femur diaphysis measurements were recorded and used to estimate fetal weight. These and other more widely used parameters were used to predict birth weight below the 10th percentile for menstrual age. Estimated fetal weight at 34 weeks achieved sensitivity of 100% and specificity of 70%, the best result for any parameter. Specificity is improved using growth measurements.

Abdomen↗
PubMed1990

Monitoring of recovery following exercise in the Doppler ultrasound evaluation of lower limb arterial disease.

Measurement of the ratio of ankle to brachial systolic blood pressure (pressure index) is an integral part of the Doppler ultrasound investigation of lower limb arterial disease. The recovery of this index following exercise gives further information regarding the clinical significance of the disease. However, serial sphygmomanometry may prolong recovery time by intermittent reduction of blood flow and for certain categories of patients the technique may prove impossible or will lead to unreliable results. The aim of this study was to investigate the use of Pourcelot's Resistance Index, measured from the Doppler blood velocity spectrum, as an alternative means of monitoring recovery. The results show that peripheral resistance is likely to fall following pressure measurement, indicating a potential effect on recovery time. There is reasonable correlation between post-exercise pressure and resistance indices (r = 0.69, P less than 0.001), and good correlation between their recovery times (r = 0.84, P less than 0.001) with no systematic deviation. Resistance index is therefore a viable alternative to pressure index for the monitoring of post-exercise recovery, and overcomes the problems associated with sphygmomanometry.

Arterial Occlusive Diseases↗
PubMed1988

Non-Hodgkin's lymphoma presenting as 'chronic active toxoplasmosis'.

We report the case of a 58 year old man in whom an unusually prolonged infection with Toxoplasma gondii was the presenting feature of an underlying non-Hodgkin's lymphoma. This case demonstrates the particular usefulness of the IgM ELISA test in monitoring disease activity.

Enzyme-Linked Immunosorbent Assay↗
PubMed1987

A new method for fetal weight estimation using real-time ultrasound.

A method for estimating fetal weight by calculating an approximate fetal volume from abdominal area, head area and femur length has been developed. Birthweights were calculated within 48 h before delivery for 434 patients, using this method and two other methods already in widespread use. Statistical analysis of the three sets of predictions gave standard deviations of 297 g for the new method, compared with 323 g and 342 g for the other methods. Further analysis of the data showed that estimates closest to the true birthweight were obtained in 41% of cases by using the new method, and in 33% and 26% of cases using the other methods.

Abdomen↗