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Biomedical subjects

N J Dodd

Publications and source records attributed to N J Dodd.

At least 55 records · Page 3Linked to original sources
PubMed1983

Use of a thromboxane synthetase inhibitor, dazoxiben, during haemodialysis.

1 We have assessed the thromboxane synthetase inhibitor, dazoxiben (UK 37248), during dialysis in a double-blind, placebo-controlled crossover study. 2 Thromboxane generation was markedly inhibited, and there was an increase in serum 6-keto prostaglandin F1 alpha levels during active treatment studies. 3 We were unable to demonstrate any reduction of platelet activation, or dialyser fibrin deposition, nor were heparin requirements altered by the drug. 4 Dazoxiben had no adverse effects.

6-Ketoprostaglandin F1 alpha↗
PubMed1983

Thrombocytopenia in renal transplantation. Diagnostic use of homologous platelet labelling with 111In oxine.

We have used homologous platelet labelling with 111In oxine in the diagnosis of thrombocytopenia occurring in a patient who had received two renal transplants. The technique enabled us to prove that platelet destruction was occurring in the right-sided, non-functioning transplant. In the presence of moderately impaired bone marrow function, this destructive process was sufficient to cause thrombocytopenia. Transplant nephrectomy relieved the thrombocytopenia.

Blood Platelets↗
PubMed1983

A demonstration of neutrophil accumulation in the pulmonary vasculature during haemodialysis.

111Indium oxine labelled autologous neutrophils were used to investigate neutropenia occurring during haemodialysis. Continuous surface counts demonstrated accumulation of labelled neutrophils in the lung, reaching a peak at 15 minutes after commencing dialysis, coincident with a fall in arterial blood and dialyser radioactivity, and a fall in arterial blood neutrophil count. Lung radioactivity returned to baseline after one hour implying reflux of labelled neutrophils into the circulation, whilst dialyser activity rose progressively and remained high even after washback of blood from the dialyser reflecting accumulation of neutrophils on the membrane.

Agranulocytosis↗
PubMed1980

Autoimmune thrombocytopenia in pregnancy.

The laboratory diagnosis of autoimmune thrombocytopenia has only recently become more satisfactory. In this study a fluorescein-labelled antiglobulin technique was used to investigate the immunochemical properties of the platelet antibody detected in a pregnant woman with severe thrombocytopenia. The antibody was autoimmune and appeared to have specificity for platelet antigens. It had both IgG and IgM components and did not fix complement. Steroids had a beneficial effect indicated by a return to normal of the platelet count, a falling antibody titre and the disappearance of detectable antibody on the patient's own platelets. Studies on the baby showed that the antibody had not crossed the placenta in detectable amounts.

Adult↗
PubMed1979

Fatal anaphylaxis in systemic mastocytosis.

A 42-year-old woman died after an episode of anaphylaxis associated with a raised serum histamine level. A diagnosis of systemic mastocytosis was established, with lymphadenopathy and hepatosplenomegaly, not associated with the usually pre-existing skin lesions of urticaria pigmentosa.

Adult↗
PubMed1978

ESR study of development of RFM/Un murine myeloid leukaemia.

The blood, spleen and liver of RFM/Un mice were examined by means of electron spin resonance (ESR) throughout the course of myeloid leukaemia induced by i.v. injection of leukaemic spleen cells. Marked changes in the concentration of iron transferrin and caeruloplasmin were observed in the blood 1 day after injection. As the disease progressed, changes occurred in the concentrations of the ascorbyl radical and of paramagnetic metal complexes in both spleen and liver. These changes are compared with those induced in RF/J mice injected with normal and leukaemic spleen cells from RFM/Un mice.

Animals↗
PubMed1976

Electron spin resonance study of changes during development of solid Yoshida tumour. I: Ascorbyl radical.

The ascorbyl radical concentration has been observed, by means of electron spin resonance spectroscopy, in the blood and spleen of female Wistar rats carrying a Yoshida tumour. The ascorbyl radical concentration of the tumour tissue itself was studied as the tumour was developing, and as it was regressing after treatment with methylene dimethane sulphonate. Changes in the concentration of this radical may be related to host tumour reactions.

Animals↗
PubMed1976

Electron spin resonance study of changes during development of solid yoshida tumour. II. Paramagnetic metal ions.

Electron spin resonance (ESR) spectroscopy was used to examine changes in the concentration of paramagnetic metal ions in Yoshida tumours carried by female Wistar rats. Blood, spleen and lymph nodes from these animals were also examined by ESR. A decrease in the concentration of a paramagnetic species associated with mitochondrial activity, and marked increases in those thought to be associated with inflammatory or immune reactions and cell lysis, were observed in the tumours within one day of implantation. During development of the tumour, and during its regression after treatment with methylene dimethane sulphonate (MDMS), further changes were observed in the concentration of the species. These were dependent on the region of the tumour examined. In blood, development of the tumour produced an increase in ceruloplasmin and a decrease in iron-transferrin. An increase in spleen weight, as the tumour developed, was accompanied by a small decrease in the concentration of species with g-values of 6-0 and 4-3, which was reversed on regression of the treated tumour. The presence of metastases in the regional lymph nodes produced distinguishable changes in the ESR spectra.

Animals↗
PubMed1976

Modification of radiation-induced oxic and anoxic damage by caffeine and potassium permanganate in barley seeds.

We show that both the immediate and post-irradiation oxygen effects in barley seeds decrease in magnitude in the presence of potassium permanganate and caffeine. This implies that these two types of oxygen effect have features in common. With the removal of the radiation-induced oxygen-sensitive sites, by anoxic hydration, caffeine potentiates the oxygen-independent component of damage, in seeds irradiated in a dry or pre-soaked state. Potassium permangenate, on the other hand, enhances the anoxic radiation damage only in seeds irradiated in a dry state. The possible mode of action of KMnO4 and caffeine in barley seeds is discussed.

Caffeine↗
PubMed1975

Electron spin resonance study of changes during the development of a mouse myeloid leukaemia. I. Paramagnetic metal ions.

The blood, spleen and liver of mice were examined by means of electron spin resonance (e.s.r.), throughout the course of myeloid leukaemia induced by intravenous injection of leukaemic spleen cells. In blood, marked increases in the concentrations of iron transferrin and ceruloplasmin occurred within the first 3 days after injection. In the spleen, changes in the concentrations of paramagnetic copper and iron complexes were detectable by about the 5th day, before any measurable splenic enlargement, whilst in the liver changes were detectable by about the 8th day. The changes occurring in blood, spleen and liver during the development of leukaemia appear to be related and they are discussed in terms of iron transport.

Animals↗