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Biomedical subjects

N Ikeda

Publications and source records attributed to N Ikeda.

At least 253 records · Page 14Linked to original sources
PubMed1991

Homicide by rectal insertion of a walking stick.

A 75-year-old disabled man was killed by a homosexual mental patient by the rectal insertion of a walking stick. The external examination of the body showed only four superficial tears in the skin of the anus. However, there was a 1 cm diameter full thickness perforation in the anterior wall of the rectum and the cause of death was the perforated rectum. The importance of the careful investigation into the circumstances of death, the background of the decreased, and the condition of the anus and rectum is discussed.

Aged↗
PubMed1991

An autopsy case of a traffic accident accompanied with fibrodysplasia ossificans progressiva: a case report.

A report is made on an autopsy case of a 19-year-old man with fibrodysplasia ossificans progressiva, who died in a traffic accident. The cause of death was acute massive haemorrhage from the lacerated liver. There was a bar of paraspinal ossifying lumps, which was hard, ramified throughout his back and restricted the movement of the thoracic vertebral column. Numerous hard swellings were palpable through the skin on the elbows, thighs, and lumbar and gluteal regions. Small bony masses were found in the muscles. According to his clinical records, radiographs and autopsy findings, he might suffer from the later stage of the disease. As a cause of the accident, though suicidal attempt by using the car or dosing was suspected, the influence of the disease itself was also considered. In connection with this case, it seemed that in the traffic death case with a rare disease, the careful investigation of the clinical symptoms and severity of the disease is very important.

Accidents, Traffic↗
PubMed1991

[Therapeutic effect of ofloxacin on intractable pulmonary tuberculosis and ofloxacin resistance of tubercle bacilli isolated from the patients. Chest DIsease Cooperative Study Unit of National Sanatoriums in Kinki District].

Ofloxacin, a synthetic antibacterial pyridone-carboxylic acid derivative, was used in the treatment of intractable pulmonary tuberculosis. In this study, the therapeutic effect of Ofloxacin on pulmonary tuberculosis and Ofloxacin resistance were analyzed. All patients had been hospitalized in eight national sanatoria in Kinki district, and were excreting tubercle bacilli resistant to various anti-tuberculosis drugs agents. Ofloxacin was given to 118 patients orally at a daily dose of 300 mg to 600 mg for more than 3 months. A few anti-tuberculosis drugs, which had failed in the negative conversion of bacilli previously, were used in combination. By Ofloxacin, 23 patients (19.5%) showed negative conversion of tubercle bacilli in sputum culture within 5 months, and they remained culture-negative for at least 6 months after conversion. Side-effects were observed in 2 patients. One complained of arthralgia and the other felt abdominal fullness. But both were not serious. From these results, it was concluded that Ofloxacin was effective for intractable pulmonary tuberculosis. The resistance of tubercle bacilli to Ofloxacin increased significantly after it was used.

Adult↗
PubMed1991

[Choroidal detachment associated with spontaneous carotid cavernous fistula].

A rare case is presented in which an 87-year-old woman with choroidal detachment was subsequently found to have an atypical carotid cavernous fistula (CCF). In this case, the intraocular pressure of the affected eye was higher than that of the contralateral eye. However, tonography showed no increased ocular pulse (amplitude of Schioetz reading) of the affected eye, which is characteristic of CCF. Choroidal detachment accompanied with CCF is thought to be a result of severe choroidal hemostasis and transudation caused by increased episcleral venous pressure. Furthermore, the enlarged perichoroidal space due to choroidal detachment reduced the ocular pulse of the affected eye. This combination may not be as rare as it has been previously reported. Attention to these symptoms can provide clues to the elucidation of the pathogenesis of choroidal detachment.

Aged↗
PubMed1990

Protein kinase C phosphorylates both the light chains and the head portion of the heavy chains of brain myosin.

Protein kinase C phosphorylated both the 19/21-kDa regulatory light chains and heavy chains of bovine brain myosin. The major phosphorylation sites of the light chains were on their threonyl residues, while those for myosin light chain kinase were on their seryl residues. Whereas several non-muscle regular myosins have been reported to be phosphorylated by different types of protein kinases at the non-helical small segments at the tail ends of the heavy chains, the phosphorylation sites for protein kinase C were localized on the head portion of the heavy chains of brain myosin. The possible role of phosphorylation of brain myosin by protein kinase C in the regulation of motility of neural cells is discussed.

Animals↗
PubMed1990

A mathematical model of atrioventricular conduction block using the excitability recovery curve of the myocardial cell.

A simple mathematical model of AV conduction block was constructed on the basis of single-cell electrophysiological experiments concerning the rate-dependent property of excitability of the AV nodal cells (the excitability recovery curve, ERC). This ERC was analogous to the phase response curve (PRC) of cardiac pacemaker cells, which the authors had previously used to construct a model of modulated parasystole. Computer simulation was used to reproduce the ERC. The single-cell ERC was then extended to the entire AV node, and this curve was used to formulate a mathematical model of AV conduction block as a nonlinear, first-order difference equation of the successive PR intervals of the ECG. This model predicted a variety of ECG patterns of AV conduction block: normal rhythm, first-degree block, and several second-degree blocks of complex Wenckebach periodicity in relation to the sinus rate and the shape of the ERC. By assuming this model it was possible to identify the underlying ERC of actual ECGs with complex Wenckebach periodicity.

Animals↗
PubMed1990

The course of respiration and circulation in 'toluene-sniffing'.

To investigate the course of respiration and circulation in death by toluene inhalation, 25 dogs were allowed to rebreathe toluene vapor in a 1-1 plastic bag expanded with air, and electrocardiogram (ECG), electroencephalogram (EEG), blood pressure (BP) in the femoral artery and intrathoracic pressure (ITP) were registered. The respiratory movement continued two times longer than that of death by suffocation using a plastic bag of the same size. In the ECG, low voltage of R waves precipitously appeared several minutes after the beginning of the experiment and continued. The BP gradually reduced by half and kept the level for several minutes. The stage was considered toluene narcosis. Toward the end of the respiratory movement, the BP increased gradually. The analysis of the ECG complexes during the toluene inhalation revealed the direct effect of toluene to the septal and ventricular muscle of the heart. But in the end of the respiratory movement, it revealed ST segment elevation and upright T. In a few experimental animals, some of the transient arrhythmia with fluctuation of the BP appeared during the course, and in one of these dogs, fatal ventricular fibrillation occurred suddenly. These findings suggested that in most cases of sudden death in 'toluene-sniffing', the cause of death is severe hypoxia during toluene narcosis, but in a few cases, it is fatal arrhythmia due to the direct effect of toluene to the heart muscle.

Animals↗
PubMed1990

Photodynamic diagnosis in respiratory tract malignancy using an excimer dye laser system.

Equipment has been developed for the early-stage diagnosis and treatment of cancer using an excimer dye laser. The excimer laser beam is obtained by exciting XeCl. A 405 nm beam tuned by DPS dye is used for tumour localization and a 630 nm beam obtained with a rhodamine B dye is used for treatment. The equipment was applied clinically on the basis of extensive experimental research. Effectiveness for cancer localization was examined in 11 cases: four were early stage (three lung cancer and one vocal cord cancer), four were stage I, two were stage III and one was stage IV. All cases were squamous cell carcinoma except for one case of adenocarcinoma. Fluorescence was recognized in all lesions and the equipment was effective for localization.

Adenocarcinoma↗
PubMed1990

Serum lipids and colorectal adenoma among male self-defence officials in northern Kyushu, Japan.

Colorectal adenoma is regarded as a precursor lesion of adenocarcinoma. In view of the controversy on serum cholesterol and colorectal cancer, the risk of colorectal adenoma was examined in relation to serum total cholesterol, triglycerides and HDL-cholesterol. In the comparison of 88 men having adenoma and 1055 men with normal colonoscopy, there was no association between serum total cholesterol and colorectal adenoma. An increased risk of adenoma was observed at the highest quartile of triglycerides and at the lowest of HDL-cholesterol. When the three serum lipids were simultaneously examined, only the relation with HDL-cholesterol remained unchanged giving odds ratio of 1.7 at the lowest quartile compared with the upper three combined (p less than 0.05). The present study is consistent with the view that the inverse relation between serum total cholesterol and colorectal cancer is due to the effects of preclinical cancer. Further clarification is needed on low HDL-cholesterol and colorectal adenoma.

Adenoma↗
PubMed1990

Alcoholic beverages and adenomatous polyps of the sigmoid colon: a study of male self-defence officials in Japan.

The drinking habits of 86 men with adenomatous polyps of the sigmoid colon were compared to those of 1184 men with normal colonoscopy among middle-aged male self-defence officials. After adjustment for rank, smoking history and rice consumption, total ethanol intake was positively associated with the risk of adenomatous polyps. The odds ratio (OR) was 2.4 (95% confidence interval (CI) 1.0-5.5) for men consuming at least 60 ml of ethanol per day. Among five alcoholic beverages (shochu, beer, sake, whiskey and wine), both sake and beer showed a dose-response relationship with the risk of adenomatous polyps although the association with beer was less striking. Shochu was the largest source of ethanol intake in the study population, but there was virtually no association between shochu consumption and adenomatous polyps. Men drinking wine had a significantly increased risk, but these men were too few to examine the relation in detail. The findings suggest that the consumption of specific alcoholic beverages rather than ethanol itself is associated with an increased risk of adenomatous polyps of the sigmoid colon.

Adenoma↗
PubMed1990

Nucleolar organizer regions in meningioma.

Seventy-eight cases of meningioma and related tumors were examined independently using a simple and reproducible argyrophilic method for the demonstration of nucleolar organizer regions (AgNORs) and staining with bromodeoxyuridine monoclonal antibody. The mean number of AgNORs per cell and the bromodeoxyuridine labeling index were shown to be linearly related (r = 0.84, P less than 0.001). The mean AgNOR number was 2.99 for meningeal sarcoma, 2.29 for anaplastic meningioma, 2.08 for hemangiopericytic meningioma. 1.72 for recurrent meningioma without atypical histological findings, and 1.52 for nonrecurrent meningioma. We noted that the mean number of AgNORs reflected the cellular kinetics of a tumor and was related to histological grade and clinical behavior.

Bromodeoxyuridine↗
PubMed1990

Correlation of in vitro bromodeoxyuridine labeling index and DNA aneuploidy with survival or recurrence in brain-tumor patients.

There are no previous reports correlating the in vitro bromodeoxyuridine (BUdR) labeling index (LI) with the clinical outcome in patients with brain tumors. The reliability of the LI as a predictor of patient survival or recurrence was examined in this study of 66 human brain tumors (19 gliomas, 18 meningiomas, and 29 others). Anti-BUdR staining was performed on surgically extirpated tumor tissue that had been treated with BUdR as previously described. Correlation of the BUdR LI with patient survival or tumor recurrence rate was carried out by the method of Kaplan and Meier. Deoxyribonucleic acid (DNA) aneuploidy was estimated in 52 cases. The results of this study indicate that BUdR LI values correlated well with the clinical course of patients with brain tumor. In comparison with patients with higher LI's, there was both a significantly higher survival rate for tumors other than meningiomas and a higher recurrence-free rate for meningiomas in patients with LI's of less than 4% and 1%, respectively. Although there was a tendency for patients without tumor aneuploidy to show better survival data than the others, no statistical difference was observed. These results suggest that the in vitro BUdR labeling method is reliable for prediction of a patient's prognosis, whereas prognosis on the basis of DNA aneuploidy alone is uncertain.

Adolescent↗
PubMed1990

Orosomucoid 1 phenotyping from human urine by isoelectric focusing.

Orosomucoid 1 polymorphism was revealed in human urine by isoelectric focusing and immunoprinting on polyacrylamide gels. The orosomucoid in urine samples was recovered and concentrated by using immobilized allo A lectin. The orosomucoid 1 phenotypes of 60 urine samples correlated with those of the corresponding serum samples.

Electrophoresis, Polyacrylamide Gel↗
PubMed1990

[Responses in extraocular muscles from magnetic stimulation of the cat brain].

In 12 adult cats, pulsed magnetic stimuli were applied to the scalp, with the center of the stimulating coil over the interparietal bone. Recordings were obtained from the superior rectus, lateral rectus and inferior oblique muscles with concentric needle electrodes. In all cats, single muscle action potentials were recorded easily in all the muscles examined with latencies of 3.2-37.5 ms (mean 15.6ms). These responses disappeared after intravenous administration of pancuronium bromide. Furthermore, the elicited action potentials in the inferior oblique muscles disappeared by amputation of the inferior oblique branch of the oculomotor nerve. In some motor units, stronger stimuli shortened the latency of the responses. In most units, however, stimulus intensity did not influence the latency of responses over a wide range. The mean latency (15.6ms) is coincident with the latency of cortical spike potentials preceding voluntary saccades. This remarkable coincidence suggests that our pulsed magnetic stimuli have a very strong possibility of generation of human saccades. Thus, magnetic stimulation of the scalp may provide further information relevant to the normal operation of the oculomotor system.

Animals↗
PubMed1989

Inhibition of purified human postheparin lipoprotein lipase by beta-adrenergic blockers in vitro.

We examined the effects of five beta-adrenergic blockers on the hydrolysis of phosphatidylcholine-stabilized triolein particles by purified human postheparin lipoprotein lipase (PHLpL) in order to evaluate the possible role of direct inhibition as a mechanism of drug-induced hypertriglyceridemia. The relative inhibitory potencies were observed in the following order: propranolol much greater than pindolol greater than metoprolol greater than atenolol greater than nadolol. There was a positive correlation between the octanol/water partition coefficients of these agents and their inhibition of lipoprotein lipase, suggesting that hydrophobicity may be one of the major determinants for PHLpL inhibition. The amount of the beta-adrenergic blockers required to produce 50% inhibition of human PHLpL was much greater than that required to inhibit purified bovine lipoprotein lipase.

Adrenergic beta-Antagonists↗