[Pharmacokinetics of In-113m-indifit].
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Biomedical subjects
Publications and source records attributed to N I Ovdienko.
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The authors present the results of an experimental study of pharmacokinetics of a new Soviet drug 99 mTc-technephyte for scintigraphy of the liver and spleen. The results of biological distribution of the agent in rat, scintigrams of the liver and spleen in rabbits and dogs have shown a high accumulation of 99 mTc-technephyte in the liver (up to 90%). The agent is prepared within one stage from a kit of reagents and 99m-sodium pertechnetate obtained using a generator.
The pharmacokinetics of 99mTc and 113mIn labeled aminopolymethyl phosphonic acids was studied in experiments on animals. Noticeable osteotropism of these compounds was shown. Scans of the rabbit and rat skeleton in health and experimental pathology 1 h after i.v. administration of these compounds were obtained making it possible to reveal the affected foci.
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