Biomedical subjects
N I Krylova
Publications and source records attributed to N I Krylova.
[Nonspecific body resistance in patients with acute, protracted and chronic pneumonia].
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[Enzymological evaluation of the hepatotoxicity of ampicillin and its therapeutic form, roscillin, in the treatment of pyelonephritis in pregnancy].
The combined enzymological investigation including determination of the total activity of asparagine transaminase and alanine transaminase, two serum enzymes, alkaline phosphatase, gamma-glutamyl transpeptidase, acetyl cholinesterase, and butyryl cholinesterase was applied to two groups of pregnant women with pyelonephritis treated with ampicillin (12 patients) and roscillin (14 patients). The investigation was performed at the following stages: before the treatment, on the 7th and on the 12th day of the treatment. No statistically significant differences in the average values of the activity of the above enzymes at these stages were observed in patients of the both groups which indicated the absence of the hepatotoxic effect of the preparations on the patients of a group as a whole. An increase in the levels of transaminases recorded in some patients after discontinuation of the treatment course was evident of a possible cytotoxic effect of the drugs without the signs of cholestasis. The effect was connected with the initial functional renal insufficiency.
[Enzymologic evaluation of the effectiveness of the hepatotropic drug catergen in chronic liver diseases].
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[Direct IgG-mediated reactivity of human neutrophils to Corynebacterium diphtheriae peptidoglycan].
The direct and IgG-mediated reactivity to C. diphtheriae peptidoglycan in the system of neutrophilic phagocytosis was studied. Peptidoglycan treated with IgG (2-20 mg/ml) isolated from commercial immunoglobulin stimulated the reduction of nitro blue tetrazolium by human neutrophils. Direct (IgG-independent) reactions were much less intensive. The problem of normal IgG opsonizing C. diphtheriae peptidoglycan is discussed.
[Effect of medical therapy on enzyme activity in myocardial infarct patients].
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[The use of aminazine as a hypotensive agent in hypertensive crises].
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[Enzyme diagnosis of mechanical jaundice].
Combined enzymodiagnostic program--estimation of total activity of blood serum enzymes aspartate aminotransferase (AST), alanine aminotransferase (AAT), alkaline phosphatase (AP), gamma-glutamyl transferase (gamma-GT), glutamate dehydrogenase (GDH), acetyl cholinesterase (ACE), butyryl cholinesterase (BCE)--was studied to evaluate its diagnostic validity in surgical clinic. In mechanical jaundice of various origin mean values of the enzymatic activities studied as well as the enzymatic coefficients were distinctly altered as compared with control values: AST/AAT, gamma-GT/AST as well as the newer coefficients BCE/ACE, AP/gamma-GT, (formula; see text). The jaundices of tumoral and non-tumoral genesis caused markedly dissimilar alterations in the coefficients AST/AAT and (formula; see text). The data of enzymological analysis may be used for differential diagnosis in jaundices.
[Changes in the functions of external respiration in patients with silicosis during treatment at the Shivanda health resort].
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[Microbiological aspects of fermenting chicken manure at various temperatures].
Mesophilic and thermophilic groups of methanogenic bacteria were found in untreated fowl manure. The thermophilic anaerobic fermentation of fowl manure leads to the development of both individual methanogens utilizing only some of the methane precursors, and syntrophic associations that are also able to utilize complex substrates. The selection of methanogenic bacteria during fowl manure anaerobic fermentation results in accumulation of thermophilic forms utilizing acetate and propionate.
[The action of exogenous RNAse on the cells of lower eukaryotes].
We studied the mechanism of growth-stimulating effect of various compounds using an exogenous RNase-micromycete model and found that the treatment with microdoses of RNase intensified the reproduction of the yeast Candida valida and growth of Aspergillus fumigatus. At the same time the respiration activity of yeast cells and fungal mitochondria as well as succinate dehydrogenase activity increased. The secretion of total protein, cellulase and cellobiase changed in the presence of RNase in the growth medium. Electrophoretic mobility of Candida valida cells enhanced by 20%. The RNase stimulating effect on microbial cells seems to result from changes in characteristics of the cell surface.