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Biomedical subjects

N Hori

Publications and source records attributed to N Hori.

155 records · Page 9Linked to original sources
PubMed1966

Electrical characteristics of Triturus egg cells during cleavage.

The membrane potential in the blastomeres of dividing Triturus egg cells increases progressively from the first cleavage to the late morula stages. Both the animal and vegetal poles show the same increasing trend in potential; there is no significant potential difference between them. Upon first cell cleavage, the total resistance of the egg cell surface in contact with the exterior decreases to about one-tenth of its value before cleavage, and then remains rather constant up to the late morula stage. The specific resistance of this membrane surface drops rather abruptly upon first cleavage, and rises progressively during the morula stage. The resistance of the junctional membrane surface of the blastomeres, that is, the membrane formed at the former planes of cleavage, is small in relation to that of the cell surface in contact with the exterior. As a result, the blastomeres are electrically coupled throughout all stages of embryonic development examined.

Animals↗
PubMedDate not supplied

Distribution and urinary excretion of aluminium injected with several organic acids into mice: relationship with chemical state in serum studied by the HPLC-ICP method.

The correlation between the in vivo tissue distribution or the urinary excretion of aluminium (Al) administered with four organic acids and the in vitro binding of Al to serum protein in the presence of the organic acids was studied: Aluminum was injected intraperitoneally into mice with an organic acid at a dose of 20 mg Al kg-1 (Al:ligand= 1:1 or 1:3). When the Al-citrate mixture was administered, hepatic and renal concentrations of Al at 3 h were low, while hepatic Al concentrations for the other three organic acids (malate, tartrate and isocitrate) were considerably higher. Compared to the sole administration of Al, urinary excretion of Al was at a high level in all organic acids. Aluminium added in vitro to control serum as an Al-citrate mixture was present only in a low-molecular-weight (LMW) fraction, while Al added with other organic acids was present in both the high-molecular-weight (HMW) and LMW fractions. Consequently, it was interpreted that Al in the LMW fractions was excreted into the urine and that a significant part of Al in the HMW fractions was transferred to the liver. The binding status of Al in serum observed in the in vitro study was also manifested in the in vivo samples obtained after the intravenous injection.

Aluminum↗