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Biomedical subjects

N Honda

Publications and source records attributed to N Honda.

At least 361 records · Page 20Linked to original sources
PubMed1977

Malignant hyperthermia and althesin.

General anaesthesia with Althesin was administered on two occasions to a patient who was identified as susceptible to malignant hyperthermia, in whom there was identified familial subclinical myopathy and once in another patient suffering from arthrogryposis multiplex congenita with a history of fever associated with two previous anaesthetics. In the first patient halothane was administered by accident in association with the Althesin, but no hyperpyrexia occurred. In the second instance nitrous oxide-oxygen and halothane were associated purposely with Althesin. In none of these cases was there any rise in temperature, muscle rigor or elevation of the serum CPK level. This experience corroborates the experimental evidence of Hall, et al.10 and Harrison, who reported that Althesin prevented the onset of hyperthermia, and the clinical reports of Page and Judelman. Althesin can be assumed to be an effective anaesthetic for malignant hyperthermia susceptible patients.

Alfaxalone Alfadolone Mixture↗
PubMed1977

Renal hemodynamics in uranyl acetate-induced acute renal failure of rabbits.

The role of renal hemodynamic alterations in the curtailment of renal function was studied in rabbits with uranyl acetate-induced acute renal failure. The day following the i.v. injection of uranyl acetate (2 mg/kg of body wt), renal blood flow (RBF) and clearance of creatinine (Ccr) decreased to approximately 60 and 20% of controls, respectively. Intracortical fractional flow distribution, estimated by radioactive microsphere method, did not change. The extraction ratio of para-aminohippurate (EPAH) decreased and the renal extraction of sodium (CNa/Ccr) increased, with minimal structural change in the kidney. Urine output increased to two to three times that of the control. After three days oliguria appeared despite complete recovery of RBF. The zonal flow redistributed toward the deep cortex. CCr and EPAH reached their minimums, concomitantly with tubular necrosis and intratubular casts. After seven days animals could be divided into the oliguric and diuretic groups. CCr and EPAH were higher in the diuretic group, while there was no significant difference in RBF and the flow distribution between groups. Regeneration of damagee tubular cells was found in the diuretic group but not in the oliguric group. The findings suggest the minor roles of RBF and the intracortical flow distribution, and a fundamental role of back leakage of filtrate across damaged tubular epithelium in the maintenance of reduced CCR and urine output during the oliguric stage in rabbits with uranyl acetate-induced renal failure.

Acute Kidney Injury↗
PubMed1977

Failure to abolish reactive hyperemia by indomethacin in denervated kidneys of rabbits.

The effect of indomethacin (10 mg/kg) on the distribution of cortical blood flow during postocclusive reactive hyperemia was evaluated in denervated kidneys of anesthetized rabbits by the radioactive microsphere technique. Renal denervation caused a slight but not significant increase in renal blood flow with no remarkable alteration in the distribution of cortical blood flow. After release of 1-min occlusion of the renal artery, hyperemic responses developed with a fractional flow redistribution toward the inner cortex. The absolute perfusion rate increased in the inner cortex but did not significantly change in the outer cortex. Indomethacin produced a decrease in renal blood flow despite elevated blood pressure. Even in the indomethacin-treated animals, postocclusive reactive hyperemia appeared concomitantly with the fractional flow redistribution to the inner cortex. The percentage repayment by reactive hyperemia of ischemia during the artery clamping was not significantly different before and after indomethacin administration. The findings indicate that indomethacin did not significantly affect the postocclusive vascular response in denervated kidneys of rabbits, thereby giving evidence against the role of prostaglandins as mediators of reactive hyperemia.

Animals↗
PubMed1976

Molecular sieving by glomerular basement membrane isolated from normal and nephrotic rabbits.

Analog chromatography with glomerular basement membrane isolated from normal and nephrotic rabbits was performed to see if there was a molecular sieving effect by the basement membrane. In a normal glomerular basement membrane column, 125I-labeled human serum globulin and 131I-labeled human serum albumin were eluted at the same position, probably at the void volume of the column. However, 125I-labeled insulin and tritiated water appeared with a delay and gave separated peaks. In nephrotic glomerular basement membrane, 125I-labeled human globulin, 131I-labeled serum albumin, 125I-labeled insulin and tritiated water gave four distinctly separated peaks in that order. By analogy with Sephadex, the sieving effect of glomerular basement membrane was demonstrated.

Animals↗
PubMed1975

Renal hemodynamics and medullary osmolal gradient in ischemic acute renal failure in rabbits.

The effects of 2 hours of renal artery occlusion were studied in previously uninephrectomized rabbits. Oliguric renal failure by arterial clamping was produced. Renal blood flow was maintained during observation periods, except for an early decrease in outer cortical blood flow without change elsewhere. During the oliguric stage medullary osmolality was markedly diminished, concomitantly with reduced (U/P)osm. Cin, EPAH and sodium reabsorption were decreased, accompanied by tubular necrosis and intratubular casts. During the early diuretic stage Cin, medullary osmolality and (U/P)osm were still reduced. Intratubular casts disappeared while regenerated tubular cells were focally observed. Two weeks after the occlusion, improved Cin, EPAH, sodium reabsorption, medullary osmolality and (U/P)osm, and regenerated tubular epithelium were found. In 7 weeks Cin and EPAH had returned to the preclamping values whereas medullary osmolality remained decreased with the appearance of medullary fibrosis. (U/P)osm was not completely restored. The findings indicate that during the oliguric stage of acute renal failure of rabbits renal blood flow is maintained, except for a decrease in outer cortical flow, and urine concentrating ability is restored more slowly than other measured functions.

Acute Kidney Injury↗