Search PubMed⌕ Search

Biomedical subjects

N Hochman

Publications and source records attributed to N Hochman.

49 records · Page 3Linked to original sources
PubMed1983

Specific herpes simplex virus antigen in human gingiva.

Herpes simplex virus type 1 (HSV-1) specific antigens were found to be present in the sulcular epithelial cells of patients that were undergoing periodontal treatment. Four out of 14 cases were positive to specific HSV-1 antigen, as demonstrated by the indirect immunofluorescent assay. No nuclear staining was seen in any epithelial cells. These observations seem to indicate that the viral genome resides in the sulcular epithelial cells of the gingiva and is possibly localized in the stratum granulosum and spinosum.

Adult↗
PubMed1982

Coexistence of defective and normal immunologic functions in lymphocytes and macrophages from osteopetrotic (op) rats.

The restoration of normal bone remodeling in osteopetrotic animals by transplantation of spleen or bone marrow cells from normal littermates has suggested that the connective tissue abnormalities associated with this disease may be attributed to defective functions of the cells of the immune system. Examination of several immunologic parameters has revealed that both thymocytes and macrophages from osteopetrotic (op) rats express some dysfunctions but retain other activities. Mitogen-induced proliferation of thymocytes from affected rats is significantly lower than that of thymocytes from normal littermates. However, mitogen-activated thymocytes from op rats produce levels of a chemotactic lymphokine that are similar to those produced by the thymocytes from normal animals. Peritoneal exudate macrophages from op rats are defective in that they migrate minimally in response to a chemotactic lymphokine or C5a. These macrophages do, however, produce lymphocyte-activating factor as efficiently as those from the unaffected littermates. The results presented here, which document immunologic defects in the lymphocytes and macrophages from the op rat, indicate that multiple immunoregulatory mechanisms involved in the degradation of connective tissue may contribute to the skeletal malformations that are present in this animal model.

Animals↗
PubMed1981

Antibodies to herpes simplex virus in human gingival fluid.

Antibodies to herpes simplex virus were found by immunofluorescent techniques in the gingival fluid of 84.0% of the persons tested. A mixture of IgG and IgA antibodies was demonstrated in 52.3% of the specimens while in 47.7% only IgG antibodies were found. Neutralization of herpes simplex virus infection in Vero cells by the gingival fluid was also demonstrated. No correlation between recurrences of herpes infection and the type of antibodies produced could be established.

Adult↗
PubMed1980

Alterations on crown contour--effect on gingival health in man.

The effect of different supragingival crown contour on the surrounding marginal gingiva was studied on four patients. All the subjects had caries, esthetic problems, and minimal periodontal problems. Each patient received two splints; one side was overcontoured, and the other side undercontoured. The splints were observed at regular intervals within a 4-month period. The result of this study suggested that factors other than variation in supragingival crown contour in the range of +/- 1 mm determined gingival response within the first 4 months in patients with a predominately healthy periodontal structure.

Adult↗
PubMedDate not supplied

Residual fluoride concentrations and scanning electron microscopic examination of root surfaces of human teeth after topical application of fluoride in vivo.

Fluoride concentrations in root surfaces of human teeth after a single topical application with a 2% acidulated sodium fluoride solution in vivo were investigated. Increased residual fluoride concentrations in the root surfaces and precipitations on the peritubular dentin, as revealed by SEM micrographs, may be factors in reducing hypersensitivity.

Dentin↗
PubMedDate not supplied

A functional aspect of anterior attrition or flaring and mode of treatment.

The phenomenon of occlusal wear has been generally reported, with no distinction being made between wear of the anterior or posterior teeth. This paper describes a group of patients without oral habits and exhibiting anterior tooth attrition or flaring with minimal posterior tooth attrition. The mandibular anterior movement patterns of the patients studied were evaluated using a Sirognathograph. These patterns appear to be the etiology for the anterior attrition or flaring present. A treatment mode allowing coexistence of this phenomenon with an anterior guidance that does not interfere with the mastication pattern is proposed. A hypothesis that might explain the clinical findings and a mode of treatment are described.

Adolescent↗