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Biomedical subjects

N Hira

Publications and source records attributed to N Hira.

12 recordsLinked to original sources
PubMed2000

[Studies of gastric acid secretion and gastric mucosal change after Helicobacter pylori eradication--the short and long-term observation].

We studied the gastric acid secretion and the histological findings of gastric mucosa in 48 patients with peptic ulcer before and after successful Helicobacter pylori (H. pylori) eradication. The pH of fasting gastric juice significantly decreased from 2.46 to 1.65 four weeks after eradication (p < 0.001). The factors such as disease, atrophic border, inflammatory cell involvement and histological atrophy were analyzed by logistic regression. Only the atrophic border was a significant and independent factor to convert the acidity after eradication, and the pH of gastric juice prominently decreased in the patients with widespread atrophic mucosal area. In the 24-hour intragastric pH monitoring, the pH3 holding time overnight remarkably decreased from 54.1% to 22.3% after eradication (p < 0.005). In the long follow-up of 17 patients (the mean follow-up period was 15.2 months), the pH of gastric juice kept a lower titer of 1.66. The mean atrophic scores in the upper body reduced from 1.5 to 0.9 (p < 0.05). In addition to the functional recovery of parietal cells after eradication, it was considered that the histological improvement of atrophy in oxyntic mucosa was associated with the recovery of pH.

Adult↗
PubMed1988

Contact laser or conventional cholecystectomy: a controlled trial.

There have been claims that the use of lasers in surgery is associated with reduced operative blood loss, trauma, postoperative pain and improved postoperative mobility. With the development of sapphire probes capable of transmitting neodymium yttrium aluminium garnet (Nd: YAG) laser light, it is now feasible to perform direct-contact low-power laser surgery. In a small randomized controlled trial, we have compared cholecystectomy performed by conventional methods (n = 11) with the same operation performed by contact laser (n = 10). Operative time, blood loss, operative stability, analgesic requirement, mobility and response to the trauma of surgery were compared. The only differences between the two groups were a significantly increased wound infection rate (P = 0.051) in the laser surgery group and a significantly increased length of operating time (P = 0.001). Thus, the laser did not confer any advantage over conventional surgery.

Cholecystectomy↗
PubMed1987

The palliative endoscopic treatment of inoperable oesophagogastric and rectal cancers: a low power direct contact laser technique.

The palliative treatment of inoperable cancers of the oesophagus, gastric fundus and rectum can be difficult and unsuccessful. Laser beam irradiation therapy offers good palliation in the majority of patients but requires several treatment sessions to achieve this. We describe a small series of patients treated with a new direct contact low power laser technique using artificial sapphire probes. After one treatment, in patients with malignant dysphagia, two thirds could swallow solids and in patients with rectal cancers bleeding was stopped or reduced and diarrhoea stopped. The interval before a second treatment was needed was three and a half weeks. We feel this technique is a useful adjuvant to conventional laser therapy of inoperable gastrointestinal tract tumours, especially in providing effective palliation in one treatment session.

Adenocarcinoma↗