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Biomedical subjects

N Hinglais

Publications and source records attributed to N Hinglais.

At least 73 records · Page 4Linked to original sources
PubMed1979

Ultrastructural study of nephritis induced in Brown Norway rats by mercuric chloride.

Chronic intoxication by mercuric chloride induces a two-phased nephropathy in Brown Norway rats characterized at first by a linear fixation of antiglomerular basement membrane antibody, then by a granular arteriolar and glomerular fixation of IgG superimposed on the linear one. On the 8th and 9th days, concomitant with the glomerular fixation of antiglomerular basement membrane antibodies, electron microscopy studies demonstrated an influx of monocytes into the glomerular and interstitial capillaries and a focal detachment of the glomerular endothelial cells. On the 14th and 15th days, subendothelial heterogeneous material and scattered subepithelial deposits appeared in glomeruli. By the 60th day, no cellular infiltration nor glomerular endothelial alterations persisted. Subepithelial glomerular deposits were seen in half of the animals, and abnormal deposits situated between muscular cells of the arteriolar walls were seen in all of them. These observations suggest that the glomerular fixation of antiglomerular basement membrane antibodies induces transient alterations of the inner aspect of the glomerular capillary wall. Arteriolar and subepithelial glomerular deposits confirm the idea that an immune-complex disease replaces the antiglomerular basement membrane antibody-mediated process. The morphologic expression of the transition between these two mechanisms is evident around the 15th day.

Animals↗
PubMed1976

[Adult Niemann-Pick disease: a 26 years follow-up. Report of a case with isolated visceral involvement, excess of tissue sphingomyelin, and deficient sphingomyelinase activity (author's transl)].

The case report of Niemann-Pick disease, in a 26 years old woman whose first symptoms appeared when she was 17 months old, is described. The disease, involving considerable hepatosplenomegaly and pulmonary infiltration, was diagnosed by the presence of lipid laden macrophages (resembling foam cells, sea blue histiocytes and kidney intermediate forms) in the bone marrow, liver and kidney, and an excess of tissue sphingomyelin and cholesterol, and a decrease in sphingomyelinase in circulating leucocytes. The results of ultrastructural, histochemical and biochemical studies on hepatic and renal lipids are reported. The relationship of the case to the sea blue histiocyte syndrome is discussed.

Adult↗
PubMed1975

[Renal transplantation in patients suffering from Fabry's disease. Kidney transplantation from an heterozygote subject to a subject without Fabry's disease].

We report the case of a renal transplantation performed with the kidney of an asymptomatic female carrier of Fabry's disease. The recipient, her daughter, had normal alpha-galactosidase levels. Eight years after transplantation, the characteristic lesions of the glomerular epithelial cells, noted as early as 11 days after transplantation, are unchanged on the successive biopsies. This observation suggests that 1) some heterozygotes (perhaps all of them) have glomerular changes, 2) the glomerular changes are not modified if the kidney is placed in a normal enzymatic "environment".

Adult↗
PubMed1975

Osmotic Nephrosis Induced by Water-Soluble Triiodinated Contrast Media in Man. A Retrospective Study of 47 Cases.

Renal biopsies were performed in 211 patients which 10 days of excretory urography or renal arteriogrpahy in which diatrizoate, iothalamate or ioxithalamate had been used. In 47 renal specimens, osmotic nephrosis of the proximal tubular cells was found. Previous renal function had been normal in 10 patients, moderately impaired in 19, and severely impaired in 18. Tubular atrophy and/or necrosis was associated with histological features in 29 of 47 patients. Diffuse osmotic nephrosis was more often found in patients biopsied soon after roentgenography and also with severe renal insufficiency, but was not necessarily associated with declining renal function. The mechanism(s) by which contrast media may induce osmotic nephrosis remains unclear.

Adolescent↗
PubMed1975

Characteristic immunohistochemical and ultrastructural glomerular lesions in Nude mice.

Kidney glomerular lesions were studied by light microscopy and immunofluorescence in 17 congenitally athymic Nude mice and 25 of their phenotypically normal littermates. The 3-month-old mice had glomerular deposits of total IgG, IgG2, IgM, and C3, but IgG1 was consistently absent and IgA was present in only 30 per cent of cases. Conversely, the 6-month-old littermates showed no deposits. However, the 9- and 12-month-old littermates had glomerular deposits of all of the immunoglobulins and C3. Kidney tissue from five Nude mice was studied by electron microscopy. In three of these five mice the mesangial and subendothelial deposits contained characteristic double layered lamellar structures approximately 130 A wide. Antinuclear antibodies were found in the serum of 3 or 10 Nude mice and 1 of 12 littermates. Different hypotheses on the origin of the characteristic lamellar structures are proposed. The significance of the early development of autoimmunity and glomerular lesions in Nude mice is discussed.

Animals↗