[Sonographic demonstration of liver hemangiomas].
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Biomedical subjects
Publications and source records attributed to N Heyder.
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Malignant haemangioendotheliomas of the liver are very rare mesenchymal tumours. Sonographically, they appear as solitary, although more frequently as multicentric, space-occupying growths with blurred and irregularly delineated outlines; the sonographic image shows both echo-dense structures and structures with a low amount of echoes, or which are even echo-free. Short-term sonographic follow-up examinations point to a tendency to rapid growth and varying echogenicity.
The ultrasonic findings of a large mesenteric lymphangioma in a man of 62 years of age are reported. Haemorrhage in some of the cystic spaces of the lymphangioma had caused an acute abdomen.
In a randomized double-blind comparative study involving a total of 50 patients divided into two equal groups, the effects of Enzym-Paractol and placebo on the ultrasonographic representation of internal organs in two planes--pancreatic and paraaortic--were compared. The visualizability was estimated as percentage figures, and revealed an improvement of about 15% for Enzym-Paractol as compared with placebo. With respect to undesired side effects, there was no difference between the two substances.
Modern sonography has led to an increased appraisal of the therapeutic consequences in cases of polypoid lesions of the gallbladder wall. In 30 patients it was attempted to differentiate between cholesterol polyps and polypoid lesions suspect for malignancy. Histologic results and data in the literature induce us to recommend cholecystectomy in solitary lesions of more than 5 mm, combined occurrence with gallstones and in patients beyond the 60th year of life.
To investigate the question as to the possibility of damage being done to the human organism by diagnostic ultrasound--with particular emphasis on the aspect of a possible cumulative effect--we investigated 20 people employed by two companies manufacturing ultrasonic equipment, who had been exposed for between 13.5 and 1,000 hours (average 152 hours) over periods varying between 0.75 and 11 years (average 4.2 years). During the examination, which included a thorough clinical work-up, haematological, laboratory and ultrasonographic investigations, particular attention was paid to the liver and blood, since the liver is usually chosen for demonstration and test purposes, and the blood is always exposed to the effects of ultrasound. We found no evidence of any harmful effect of ultrasound on the human organism, nor were there any tendencies correlated with the period of exposure to be found. A newly detected diabetes mellitus was interpreted as an incidental finding.
In patients with an increased surgical risk, common bile duct stones can be removed with the aid of endoscopic papillotomy. Most stones are either passed spontaneously, or can be drawn out with the Dormia basket. Excessively large stones can first be smashed with the mechanical lithotripter. Some 20% of the stones presenting are, however, too hard to be smashed in this way. A technique was accordingly developed for smashing such bile duct stones using ultrasound. A prerequisite for this technique was the development of an acoustic wave guide that would conduct ultrasound energy even when bent. With this procedure, it will soon be possible to destroy bile duct stones in situ.
40 patients were examined by peroral endoscopic ultrasonography with two new prototypes (Prototype II and III, Olympus Optical Co., Tokyo, Japan). Indications were given by various intestinal diseases. Topographical orientation could be difficult, but was facilitated by standard positions of the instrument. The organs identified included liver, gallbladder, common bile duct, pancreas, spleen and kidneys. Pathological lesions of the mentioned organs were characterized by the reflex pattern known from external ultrasonography. Up till now endoscopic sonography is not a routine method but may give additional information to peroral endoscopy and external ultrasonography without replacing these methods.
Endoscopic ultrasonography was developed in an attempt to utilize the improved resolution of small-parts ultrasonography also in the investigation of organs located deep within the body as opposed to at the surface. A further expected advantage vis-à-vis external ultrasonography was the avoidance of the frequently obstructing air. In an initial study of 40 patients with a variety of different diseases of the upper abdomen, we were indeed able to utilize the advantages described, with the result that diagnostic information was obtained that neither external ultrasound nor endoscopy was able to provide. A limitation of endoscopic ultrasonography is the fact that the "path" of the transducer is predetermined by the course of the gastrointestinal tract. A further difficulty is the anatomic orientation. To combat this latter problem, our working group has under X-ray control, established standard position for the ultrasound endoscope.
Eighty patients presenting with various diseases of the upper abdominal organs were investigated in an initial series of examinations performed with an ultrasonic endoscope provided with a mechanical sector scanner (7.5 MHz rated frequency, sector selectable between 90 degrees and 180 degrees), and/or a linear array device (7.0 MHz rated frequency, field of view 31 mm). Orientation, which was initially difficult, was facilitated by establishing standard positions. The pancreas, liver, gallbladder, bile duct, spleen, the two kidneys, the vessels of the upper abdomen, the wall of the stomach and, of course, the heart, are all accessible to endoscopic diagnostic ultrasound. At the present state of our knowledge, the method does not appear suitable for the systematic diagnostic work-up of the upper abdominal organs, but in certain cases it would seem to be a useful supplementary examination to external ultrasonography or endoscopy.
Metastatic obstructive jaundice usually results from an occlusion of the common hepatic or bile duct. More rarely, the underlying cause is a disseminated intrahepatic infiltration that has led to the occlusion of the bile canaliculi. The endoscopic-radiological examination techniques usually permit a reliable differentiation between neoplasms originating primarily in the biliary tract, and ductal occlusions caused by metastatic disease. In addition to this, both ERC and PTC permit the placement of an internal or external biliary drain during one and the same procedure. ERC represents a highly suitable method for the follow-up monitoring or documentation of the therapeutic effect of biliary drainage, radiotherapy and/or polychemotherapy. With the aid of regular follow-up examinations, recurrent disease can be detected early on, and appropriately treated.
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The possibilities of a transgastric ultrasonic diagnosis of the pancreas and other organs are investigated in an initial series of 50 examinations using two different ultrasonic endoscopes.
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