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Biomedical subjects

N Hashimoto

Publications and source records attributed to N Hashimoto.

At least 721 records · Page 40Linked to original sources
PubMed1981

Vanishing cerebral aneurysm in serial angiography.

The angiographically documented spontaneous thrombosis of an internal carotid-posterior communicating aneurysm in a 63-year-old woman is reported. Serial angiography performed 10, 17, and 29 days after the initial attack of subarachnoid hemorrhage demonstrated progressive thrombosis of the aneurysm. Clinical analysis of this case and a review of the literature suggest that vasospasm and the relative narrowness of the aneurysmal neck played crucial roles in the spontaneous thrombosis of the aneurysm, although neither is definitely responsible.

Adult↗
PubMed1981

Occurrence of Yersinia enterocolitica in wild animals.

Yersinia species were isolated from 16 of 495 small wild animals and from 1 of 38 foxes. The animals were trapped in seven regions of Hokkaido, Japan. Of the 17 strains isolated, 9 were Yersinia enterocolitica O6; 2 were Y. enterocolitica O5A; 1 was Y. enterocolitica, O4; 1 was Y. enterocolitica O9; 1 was Yersinia pseudotuberculosis IVB; and 3 were sucrose-negative strains. Yersinia pestis was not isolated. The O6 organism was most prevalent in large red-back mice (Clethrionomys rufocanus bedfordiae) and showed significant differences in its mode of distribution according to region. Incidence of the O6 organism in the ileum of the animal was threefold that in the cecum, and the organism was recovered at approximately 10(5) cells per g of cecal contents per c. rufocanus bedfordiae animal.

Animal Population Groups↗
PubMed1980

Clinical analysis of arteriovenous malformations in children.

28 cases of arteriovenous malformations (AVMs) in children were analyzed and compared with 18 adolescent and 106 adult cases. The findings were: (1) intracerebral hematoma due to rupture of AVMs and focal neurologic deficits were more frequent in children, (2) Operative mortality was higher in children than in adults in cases where total removal was not feasible. (3) Follow-up results suggested that the prognosis in children was less favorable than in adults. (4) When dealing with spontaneous intracerebral hematoma in children care should be taken to search for underlying cryptic AVMs.

Adolescent↗
PubMed1980

Experimentally induced cerebral aneurysms in rats: Part VI. Hypertension.

Cerebral aneurysms were induced in rats treated with unilateral ligation of the common carotid artery and hypertension produced by renal infarction with or without beta-aminopropionitrile, one of the lathyrogens. In this experiment, cerebral aneurysms developed more frequently than in the previous experiments in which hypertension induced by deoxycorticosterone and salt had been used. It was demonstrated that deoxycorticosterone was not essential to the development of the lesion. Regardless of its type, hypertension combined with carotid ligation played a primary role in the production of cerebral aneurysms in rats. Sodium chloride enhanced the systolic hypertension and thus increased the incidence of lesions. The role of hypertension in the development of cerebral aneurysms in humans is discussed.

Aminopropionitrile↗
PubMed1980

Experimentally induced cerebral aneurysms in rats: Part V. Relation of hemodynamics in the circle of Willis to formation of aneurysms.

All the rats were made hypertensive and fed beta-aminopropionitrile. Among them, cerebral aneurysms were never found in rats without carotid ligation. In rats with ligation of one or both common carotid arteries, cerebral aneurysms developed on the vessels where hemodynamic stresses were apparently increased. The relationship of hemodynamics in the circle of Willis to the development of cerebral aneurysms is discussed, being compared with findings in spontaneous lesions in man.

Aminopropionitrile↗
PubMed1979

Smouldering epidemic of Yersinia pseudotuberculosis in barn rats.

Yersinia pseudotuberculosis was isolated from 8 (8 Rattus norvegicus) of 270 (259 R. norvegicus and 11 R. rattus) rats examined. Seasonal variation was not found in the incidence of isolations. The isolation occurred almost equally in both young and old rats. The isolated strains were determined as serovar IB in one rat, and serovar IVA in seven rats. The strains were isolated from the contents of the intestinal tract (the duodenum, jejunum, ileum, cecum, colon, and rectum), the spleen, liver and mesenteric lymph nodes; they were not detected in the kidneys. Agglutinin titer in the eight rats was no more than 32.

Animals↗
PubMed1979

Assay of 25-hydroxyvitamin D3 in human plasma by high-performance liquid chromatography.

A method using preparative and analytical high-performance liquid chromatography (HPLC) is proposed for the assay of 25-hydroxyvitamin D3 (25-OH-D3) in human plasma. A constant volume (0.2--2.0 ml) of a plasma sample was saponified. The unsaponifiable matter was first applied to preparative HPLC using a column of the straight-phase type (Zorbax SIL) in order to separate a 25-OH-D3 fraction from lipophilic concomitants giving ultraviolet-absorbing noise. Then, the separated 25-OH-D3 fraction was applied to analytical HPLC using a column of the reversed-phase type (Zorbax ODS) in order to measure the content of 25-OH-D3 from the peak height. This is a revised method from Jones (1978): Clin. Chem., 24, 287--298). The results showed that the clean-up procedure by the first preparative HPLC was successfully performed because the peak corresponding to 25-OH-D3 on the chromatogram of the second analytical HPLC was not disturbed by any other interfering peaks. Moreover, recovery through the whole procedure was satisfacotry (about 100%) and the procedures of saponification and isolation of the unsaponifiable matter diminished the overload to the columns. These are the revised points of Jones' method. When two determinations were performed on 12 samples of plasma taken from normal adults in October, the values were 22.6 +/- 4.8 and 21.0 +/- 3.6 (mean +/- SD) ng/ml, respectively.

Adult↗
PubMed1979

Experimentally induced cerebral aneurysms in rats: Part III. Pathology.

Experimentally induced cerebral aneurysms in rats treated with unilateral ligation of the common carotid artery, deoxycorticosterone and salt hypertension, and beta-aminopropionitrile, were studied macroscopically and with light-microscopy. The material consisted of 13 aneurysms located on the anterior cerebral-anterior communicating arterial complex and one on the posterior cerebral artery. The findings were generally in accordance with that of spontaneous lesions in man. The results show the validity of these experimental aneurysms as a model for saccular cerebral aneurysms in man.

Aminopropionitrile↗
PubMed1979

Experimentally induced cerebral aneurysms in rats: part II.

An experimental condition that permits easy inducement of cerebral aneurysms in rats is reported. Previously, we demonstrated that saccular cerebral aneurysms were inducible in experimental animals and suggested that adult rats might be more preferable for inducing the lesion. Therefore, a longer-term study was performed intending to increase the incidence of cerebral aneurysms, using only adult rats. Adult rats were treated with ligation of one common carotid arter, deoxycorticosterone and salt hypertension, and beta-aminopropionitrile. Cerebral aneurysms developed in eleven of 30 rats which died 11-21 weeks after the start of the beta-aminopropionitrile feeding. All aneurysms were located on the anterior cerebral-anterior communicating arterial complex. Contributory mechanisms are discussed.

Aminopropionitrile↗