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Biomedical subjects

N Hashimoto

Publications and source records attributed to N Hashimoto.

At least 685 records · Page 38Linked to original sources
PubMed1984

[Surgery of vertebral artery aneurysm at the origin of posterior inferior cerebellar artery--with special reference to operative technics in cases with difficulty in direct operation].

Twenty-two patients with posterior inferior cerebellar artery (PICA) aneurysms were treated in our department from 1965 to 1982. Except for six cases with peripheral PICA aneurysms, all aneurysm were located on the vertebral artery at the origin of PICA (VA-PICA aneurysm). Direct approach to the aneurysm was carried out in 11 cases out of 16 with VA-PICA aneurysm. We encountered difficulties in access to the aneurysm in 5 cases (case 2,4,6,13,15) and in clipping procedures in 4 cases (cases 6, 7, 10, 15). Surgical procedures through either bilateral (case 2,4) or unilateral suboccipital craniotomy included exploration in 1 case; wrapping in 1, proximal vertebral artery clipping in 3 and neck clipping in 6. These difficulties encountered during operation were evaluated in relation to angiographical findings. The aneurysms located between 0 to 5 mm from the midline or more than 21 mm from the lateral point of the foramen magnum could be reached with difficulty through unilateral suboccipital craniotomy (Figure 3,4). The aneurysms with the dome directed posteriorly had to be treated carefully because of their possible adhesion to or invagination into the medullar oblongata. The aneurysms with the dome directed medially were difficult to be clipped because they existed on the opposite side of the vertebral artery. Although all aneurysms overlying the lower third of the clivus, even on the midline, can be exposed through unilateral suboccipital craniotomy, great care should be taken especially to the aneurysms located in high position, with the dome directed medially or posteriorly, and with the distal vertebral artery running medially.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1983

Getah virus in Aedes vexans nipponii and Culex tritaeniorhynchus: vector susceptibility and ability to transmit.

Vector competences of Aedes (Ae.) vexans nipponii (nip.) and Culex (Cx.) tritaeniorhynchus to Getah virus were assessed by using a membrane feeding technique. The Getah virus was present at high titer in both species of mosquitoes after 21 days of extrinsic incubation at 28 degrees C. Infection rates on 21 post-feeding were 100 per cent (4/4) for Ae. vexans nip. at a virus dosage of 10(5.3) PFU/ml and 60 per cent (3/5) for Cx. tritaeniorhynchus at similar virus dosage. More than 10(3.5) PFU of virus was detected in salivary glands of both species of mosquitoes on day 21 of extrinsic incubation. Forty percent (2/5) of Ae. vexans nip. transmitted the virus into serum-agar after ingesting 10(4.3) PFU/ml of virus blood mixture. In experiments with Cx. tritaeniorhynchus ingesting 10(7.5) PFU/ml of virus blood mixture, 57 per cent (4/7) were able to transmit the virus to suckling mice and 59 per cent (10/17) transmitted the virus into serum-agar.

Aedes↗
PubMed1983

The size of cerebral aneurysms in relation to repeated rupture.

The size of ruptured cerebral aneurysms in 407 cases were studied angiographically in relation to the number of times of rupture. The size of aneurysms was not influenced by the number of clinically documented episodes of bleeding. Patients with long-term clinical courses of untreated ruptured aneurysms had significantly larger aneurysms than in the general patient population. The result indicates that aneurysmal enlargement is not closely related to their rupture when considering aneurysmal growth in general. The mechanism of growth of cerebral aneurysms is discussed.

Cerebral Angiography↗
PubMed1983

Extramedullary plasmacytoma associated with a Castleman's lesion of the cervical nodes.

A rare case of extramedullary plasmacytoma seen in a patient with a Castleman's lesion is described. The mass occurred in the cervical nodes of a 61-year-old female patient, and the primary site was the intra- or peri-parotid nodes. The histological examination revealed abnormal characteristic lymph follicles and nodular proliferation of plasma cells in the same lymph nodes. The neoplastic change of plasma cells was studied on the basis of the immunoperoxidase (PAP) method. The patient is well without recurrence 15 months after total resection.

Female↗
PubMed1983

Extramedullary plasmacytoma with crystal inclusions arising from the palatal tonsil.

A case of extramedullary plasmacytoma of the left palatal tonsil in a 51-year-old woman is reported. The histological features of the tumor are typical, except for the appearance of crystal inclusions in plasma cells, histiocytes and matrices. The developmental process and the nature of the crystal inclusions are discussed, based on electron-microscopic findings. The patient has been followed for one year post-operatively, and no clinical evidence of recurrence has been observed.

Crystallography↗
PubMed1983

Cross-resistance to fecal excretion of Yersinia enterocolitica in mice by oral vaccination of killed cells.

Mice vaccinated orally with heat-killed cells of serovar O3 of Yersinia enterocolitica were protected only against fecal excretion of the homologous serovar, whereas Formalin-killed cells provided cross-protection against serovar O9 and vice versa. Serovar IVA of Yersinia pseudotuberculosis, when Formalin-killed, also provided cross-protection against Y. enterocolitica. On the other hand, Serratia liquefaciens and serovar O6 strains did not furnish cross-protection.

Animals↗
PubMed1983

Epidural hematomas of the posterior fossa in children.

The authors report 3 cases of epidural hematoma of the posterior fossa in children. The clinical signs and symptoms are discussed. Onset of symptoms is not necessarily acute. The radiological findings are discussed. Epidural hematomas of the posterior fossa in children have a tendency to liquefy earlier than supratentorial hematomas. We emphasize the value of computed tomography for the diagnosis of epidural hematoma of the posterior fossa. One should keep in mind the possibility of the presence of an epidural hematoma of the posterior fossa in the treatment of head injury in children, even in the case of a minor head injury.

Cerebral Angiography↗
PubMed1983

Isolation of virus causing hemorrhagic fever with renal syndrome (HFRS) through a cell culture system.

Twenty-three rat lung specimens collected in outbreaks of hemorrhagic fever with renal syndrome (HFRS) in three medical institutions were inoculated onto the VERO-E6 cell monolayers. After several blind passages, an agent growing serially in the cell cultures and reacting specifically with known HFRS-positive sera was isolated from two of these specimens. The two isolates were antigenically identical each other. The agent, named strain SR-11, was identified as the causative virus of HFRS by its antigenic identity with E6 cell-adapted HFRS virus, Hantaan 76-118 strain, and the specific reactions with sera from various HFRS cases.

Adolescent↗
PubMed1983

Immunogenicity of HBeAg in the New York Blood Center hepatitis B vaccine.

A new hepatitis B vaccine has been developed which contains both HBsAg and HBeAg since evidence suggests that anti-HBe may have useful biologic activities. It was thus important to determine whether HBeAg is immunogenic in this type of a preparation. We now report data indicating that highly purified HBsAg particles, derived from HBeAg containing plasma, release a proportion of their contained cryptic HBeAg following the detergent treatment used in the preparation of this vaccine. Both the soluble and the residual particle associated HBeAg are immunogenic in guinea pigs. There was no detectable anti-HBe response in animals injected with similar HBsAg particles which had not been exposed to detergent.

Animals↗
PubMed1983

Acetone-treated agglutinin against Yersinia pseudotuberculosis in free-living rats.

Retrospective investigation was done on Yersinia pseudotuberculosis infection in barn rat populations living in an Yersinia endemic area and in zoo rat populations living in a nonendemic area. The OH agglutinins against Y pseudotuberculosis were normally distributed within both populations. Most of the OH agglutinin titers and many O agglutinin titers were reduced by treatment of sera with acetone. Sera with O and OH agglutinin titers were assigned to 2 groups, one with a titer less than 1:8 and the other with a titer of greater than or equal to 1:8. Rats harboring the organism did not possess O or OH agglutinin titers greater than 1:8 in acetone-treated sera. In most nontreated sera, OH agglutinin titers were higher than were the O agglutinin titers. However, in most acetone-treated sera, O agglutinin titers were equivalent to OH agglutinin titers. Differences by region and age were observed in acetone-treated O agglutinin titers of greater than or equal to 1:8 against Y pseudotuberculosis. Therefore, it is recommended that to detect antibody against Y pseudotuberculosis in rats, sera should be treated with acetone before the test and O antigen should be used.

Acetone↗
PubMed1983

Liver cell membrane antibody detected by protein A and isolated rabbit liver plasma membrane in sera of patients with chronic liver diseases.

Using the plasma membrane fraction isolated from rabbit liver (RLPM), we detected non-species specific IgG antibody against liver cell surface membrane in the sera from the patients with chronic liver diseases. The sea were treated with dithiothreitol and iodoacetamide, and absorbed with sufficient amount of actin isolated from rabbit striated muscles. The antibody was detected by incubation of RLPM with the treated and absorbed sera and subsequent determination of IgG bound to RLPM by 125I-staphylococcal protein A. It was found mainly in the patients with autoimmune hepatitis (12 of 28) and liver cirrhosis (eight of 24). It occurred more frequently in HBsAg negative liver cirrhosis than in HBsAg positive forms (six of 13 vs two of 11). The frequency of the antibody was low in chronic hepatitis except autoimmune hepatitis, and primary biliary cirrhosis. Thus the antibody against RLPM was an immunological marker of autoimmune hepatitis and HBsAg negative liver cirrhosis. The occurrence did not correlate with those of anti-smooth muscle antibody, anti-nuclear antibody and anti-mitochondrial antibody. In two cases of autoimmune hepatitis, the antibody against RLPM decreased with clinical improvement induced by corticosteroids.

Adrenal Cortex Hormones↗
PubMed1983

[Anti-anoxic effect of 4-(o-benzlphenoxy)-N-methylbutylamine hydrochloride (MCI-2016)].

Anti-anoxic effects of MCI-2016 were compared with those of drugs for cerebrovascular diseases, tricyclic antidepressants and physostigmine in mice. Minimal effective doses of MCI-2016 which significantly increased the survival time or gasping duration were 12.5 mg/kg, p.o. for hypoxia, 50 mg/kg, p.o. for KCN-induced anoxia, and 100 mg/kg, p.o. for decapitation-induced gasping. As a whole, these effects of MCI-2016 were superior to those of reference drugs for cerebrovascular diseases. MCI-2016 was also shown to be effective under a consecutive administration schedule. In marked contrast to the effect of MCI-2016, tricyclic antidepressants significantly shortened the survival time under hypoxia. Considering that atropine shortened and physostigmine markedly increased the survival time under hypoxia, involvement of anti-cholinergic action may be postulated for the shortening effect of tricyclic antidepressants. The anti-hypoxic effect of MCI-2016 as well as physostigmine was diminished by atropine treatment. Furthermore, MCI-2016 exhibited a combination effect with physostigmine at optimal doses. Although the influence of norepinephrine uptake inhibitory action on the hypoxic condition are not clear in the present study, these results may suggest that activation of CNS cholinergic system is involved as one of the causative mechanisms for anti-anoxic effect of MCI-2016.

Animals↗