Search PubMed⌕ Search

Biomedical subjects

N Harada

Publications and source records attributed to N Harada.

At least 649 records · Page 36Linked to original sources
PubMed1977

Malignant tumors in choledochal cysts.

Between 1960 and 1975, 17 patients with congenital cystic dilatation of the common bile duct (choledochal cyst) were treated and three were associated with malignant tumors in the cysts and one was with carcinoma of the gallbladder. Preoperative diagnosis of adenocarcinoma in the choledochal cyst was established in one patient by cytologic examination of the bile which was obtained during the procedure of endoscopic pancreaticocholangraphy (EPCG) and percutaneous transhepatic cholangiography (PTC). Definitive treatment of the choledochal cysts associated with malignant tumors in the biliary tract was accomplished by excision of the cysts with tumor and choledochojejunostomy in two patients, by cystoduodenostomy following external drainage in one and by cholecystectomy with resection of invaded transverse colon in one with cancer of the gallbladder. Successful excision of choledochal cysts in 11 patients including three cases associated with malignant tumors in the biliary tract during the last 15 year period is the basis of this report.

Adenocarcinoma↗
PubMed1977

Increase in cytochrome contents of liver mitochondria on feeding rats a low casein diet.

Williams et al. (1) investigated the changes in amounts of total mitochondrial protein and cytochromes in the liver of rats fed a protein-free diet for a long period, and found that there was a marked similarity between changes in amount of total mitochondrial protein and that of cytochromes. Present experiments were performed to clarify whether under a more mild protein-deficient state the relationships found by Williams are applicable or not by investigating the changes in contents of cytochromes per unit amount of mitochondrial protein when rats were fed a low case diet. A 4% casein diet was used as a low casein diet, and a 25% casein diet was used as a control diet. Rats were fed the test diets for 70 to 90 days. The results show that the contents of all cytochromes a, b, and c1 + c assayed and expressed as nmoles per mg of mitochondrial protein were significantly higher in rats fed a low casein diet than those in rats fed a control diet. These suggest that relationships found by Williams in a severe protein-deficient state would not be applicable in a more mild protein-deficient state.

Animals↗
PubMed1977

Endoscopic aspiration biopsy of the pancreas.

Preoperative endoscopic aspiration biopsies were performed on 51 patients with pancreatic lesions using either a duodenal or gastric fiberscope and a newly designed biopsy needle. The accuracy of this method in the diagnosis of carcinoma of the pancreas was 84.0%. Although there were three false-negative diagnoses, there were no false-positives. No complications that could be attributed to this procedure were encountered.

Adenocarcinoma↗
PubMed1976

Characteristic inhibition of in vitro swelling of purified rat liver mitochondria induced by Ca2+ or thyroxine by feeding rats a low casein diet.

It has been shown previously by the author that the structure of rat liver mitochondria is changed by a low casein diet. In the present experiments, using the free fatty acid producing substances Ca2+ and thyroxine, and the free fatty acid sodium oleate, the influence of a 4% casein diet on the in vitro swelling process of purified rat liver mitochondria was investigated by following the decrease in optical density at 520 nm after addition of one of the swelling agents. Swelling due to hypotonicity was also investigated. Rats were fed the test diets for 80 to 100 days. Mitochondria were purified by washing three times; after each wash the isotonic suspension was centrifuged at 3,000 X g for 6 minutes. The results show that the in vitro swelling of mitochondria induced by Ca2+ or thyroxine was inhibited greatly in the early period of swelling in rats fed a low casein diet. By comparison to this, there was not a notable effect of a low casein diet on the rate of swelling induced by sodium oleate. But in the case of sodium oleate, the values of optical density were always higher in rats fed a low casein diet, and the differences between two groups were always significant. Swelling due to hypotonicity was not affected at all by a low casein diet.

Animals↗
PubMed1976

Changes of the vibratory sensation threshold in workers using vibrating tools.

Vibratory sensation thresholds of ten fingertips of each person were measured by each of the three frequencies in groups using three kinds of vibrating tools and the control groups. The subject groups were using leg-drill (n=37), chipping-hammer (n=25) and chain-saw (n=19). The control groups were engaged in desk work or outdoor work in a bureau of forest management (n=24), a local forest office (n=30) and a gas company (n=22) (Table 1). The tested frequencies were 63 Hz, 125 Hz and 250 Hz. The room temperature was kept at 20 degrees C. 1) The threshold values were found in such order as V greater than IV greater than III greater than I and II-finger in the subject groups, whereas I and V greater than II, III and IV-finger in the control groups. No significant difference between left and right hands was found in any group, both the subject and the control. 2) The threshold values were significantly higher in the chipping-hammer group and the chain-saw group than in the control (p less than 0.05 at 63 Hz, p less than 0.01 at 125 Hz and 250 Hz). They were higher in the leg-drill group than in the control but it was statistically not significant. 3) Regression analysis was performed about age and experience-years of the subject groups which were thought to have an effect upon the threshold change. But the effect of both factors to the threshold values were small in all subject groups. 4) The patterns of threshold values made up by each of the three frequencies were different among the three subject groups. The chipping-hammer group had the higher vibratory sensation threshold shift in the order of 250 Hz, 125 Hz and 63 Hz, the leg-drill group had almost equal threshold shift among the three frequencies, and the chain-saw group had the intermediate tendency between the other two groups. 5) Frequencies of 125 Hz and 250 Hz were more advantageous than that of 63 Hz in order to discriminate between the subject group and the control. Both 125 Hz and 250 Hz vibratory sensation threshold should be measured to find early disorders of vibration disease if possible, because the relation between thresholds of 125 Hz and 250 Hz was not so linear. 6) The observed significant differences of threshold values among the control groups were thought to be caused by different climatic circumstances.

Adult↗
PubMed1975

Portal hypertension due to hepatic artery-portal vein arteriovenous fistula--a case report.

A case of portal hypertension secondary to traumatic hepatoportal arteriovenous fistula with portal fibrosis was successfully treated by ligation of the afferent hepatic arteries which decreased significantly portal pressure and corrected the abnormal blood inflow to the portal vein via A-V fistula resulting in a recovery of the disturbed liver function. Collateral blood supply from the left hepatic artery into the right hepatic lobe was found to be quite satisfactory after the ligation of the hepatic artery. Hemodynamic data and clinical findings of the present case suggest that the mechanism responsible for the portal hypertension is the inflow block resulting from the interruption of portal venous flow by the inflow of arterial blood via A-V fistula and the subsequent increased blood pressure in portal vein radicals.

Adult↗