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Biomedical subjects

N H Raskin

Publications and source records attributed to N H Raskin.

At least 37 records · Page 2Linked to original sources
PubMed1986

Thunderclap headache: symptom of unruptured cerebral aneurysm.

Many patients with a ruptured berry aneurysm report an intense sentinel headache of sudden onset in the weeks before rupture. Such headaches have been attributed to a leak of blood, which implies that partial rupture has occurred. A case is reported of a patient who had severe headaches which seemed to be caused by an unruptured cerebral aneurysm, accompanied by diffuse cerebral vasospasm. Headache episodes with the thunderclap profile may require angiography for diagnosis even if the cerebrospinal fluid is bloodless.

Adult↗
PubMed1986

Neuropsychologic alterations in classic and common migraine.

A neuropsychologic test battery was administered to 16 outpatients with classic migraine and 15 outpatients with common migraine between attacks and 15 matched nonheadache volunteers. Both migraine groups demonstrated significantly greater average neuropsychologic impairment and more self-reported cognitive difficulties than the nonheadache control group. Current medication use did not explain the relative neuropsychologic impairment. Both classic and common migrainous disorders seem to involve a disturbance of cerebral function beyond the attack itself.

Adult↗
PubMed1986

Repetitive intravenous dihydroergotamine as therapy for intractable migraine.

For patients with chronic intractable headache, we compared a new treatment and a traditional one. Fifty-five patients (36 dependent on ergotamine, analgesics, diazepam, or corticosteroids) were given IV dihydroergotamine (DHE) and metoclopramide every 8 hours. Fifty-four age- and sex-matched patients (38 drug-dependent) were given diazepam intravenously every 8 hours. Forty-nine of the 55 DHE-treated patients became headache-free within 48 hours, and 39 of them sustained benefits in a mean follow-up of 16 months. In contrast, 7 diazepam-treated patients became free of headache within 3 to 6 days, and 31 had improved somewhat in 10 days. Repetitive IV DHE helps to terminate cycles of intractable migraine.

Adult↗
PubMed1981

Genetic analysis of susceptibility to experimental allergic encephalomyelitis in guinea-pigs.

Genetic analysis of susceptibility to experimental allergic encephalomyelitis (EAE) was performed in guinea-pigs. The results indicate the existence of two Ir genes to EAE in susceptible strain 13 guinea-pigs. One gene is linked to the major histocompatibility complex (MHC) of this species, while the other one is located outside the MHC. The two genes segregate independently and both of them must be expressed to render the animal susceptible to EAE.

Animals↗
PubMed1981

Headache.

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Analgesics↗
PubMed1980

Icepick-like pain.

The incidence and clinical characteristics of sharp, jabbing pain about the head were studied in 100 migraineurs and 100 control subjects. Among the controls, 3% had experienced paroxysmal sharp cranial pain, whereas 42% of the migraineurs had made this observation (p less than 0.001) and half of them experienced it more often than monthly. The pain was usually (45%) unifocal at the temple or orbit, was described as icepick-like by 52% of the patients, and was often (69%) experienced concurrently with headache. Icepick-like pain appears to be a manifestation of migraine and should be distinguished from trigeminal neuralgia.

Adolescent↗
PubMed1980

Headache.

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Brain Diseases↗
PubMed1977

Carotidynia.

Nosologic uncertainty about carotidynia has arisen, in part, because the syndrome was initially classified as an atypical facial neuralgia. More recently, carotidynia has been characterized as a recurring vascular neck pain, often accompanied by carotid tenderness and soft tissue swelling and sometimes by vascular headaches. We now report that drugs useful in the prophylaxis of migraine appear to be effective in carotidynia. Eight women (ages 39 to 77) with unilateral, episodic neck pain of 1 to 19 years' duration have been observed for periods ranging from 7 months to 6 years. All experienced marked relief in the intensity and frequency of their pain syndromes after the administration of methysergide, ergonovine maleate, propranolol, or nortriptyline. No patient had evidence of arteritis. The responsiveness of both migraine headaches and carotidynia to similar drugs suggests a common pathophysiologic mechanism.

Adult↗