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Biomedical subjects

N H Gilinsky

Publications and source records attributed to N H Gilinsky.

44 records · Page 3Linked to original sources
PubMed1983

Evaluation of an extended pancreatic function test in normal subjects and in patients with chronic pancreatitis.

Exocrine pancreatic response was evaluated in patients with varying degrees of pancreatic damage and in control subjects by means of an extended pancreatic function test (PFT). A second injection of secretin and pancreozymin was given after completion of the standard test. The discriminatory value of the standard PFT with regard to bicarbonate and enzyme output was not enhanced by a second bolus dose of hormones. It is concluded that the secretory potential of damaged pancreatic exocrine tissue cannot be exhausted by prolonged stimulation employing repeat bolus stimulation.

Adult↗
PubMed1983

Immunoproliferative small-intestinal disease: follow-up of an alpha-chain negative, lymphoma-free group.

Six patients had the clinical and pathological features of immunoproliferative small-intestinal disease (IPSID). All were female with malabsorption or growth retardation in whom testing for alpha-heavy chains was repeatedly negative. They were followed for a mean of 7.5 years, during which time no significant alteration in the jejunal biopsy appearances of five patients has occurred, none have developed lymphomas.

Adolescent↗
PubMed1983

The natural history of radiation-induced proctosigmoiditis: an analysis of 88 patients.

The records of 88 patients with radiation-induced proctosigmoidosis seen over an eight year period were reviewed. Eighty-four (95 per cent) had been irradiated for a gynaecological malignancy. The peak incidence of bleeding occurred after a latent period of nine months from the time of irradiation. Twenty-five subjects (28 per cent) had associated injury to the urinary tract. A wide spectrum of radiological abnormalities found on barium enema is described. Twenty-four patients (27 per cent) underwent operations for radiation-induced injury to the colon and urinary tract. Operations on the bowel were attended by a high complication rate (79%). A clinical classification based on bowel symptoms is presented. Those whose only symptom was low grade rectal bleeding (Group I) had the most favourable outcome and of these, 35 per cent stopped bleeding spontaneously by six months. Patients who required frequent transfusions (Group II) had an increasing mortality rate with the passage of time. Patients whose predominant symptoms were pain and bowel dysfunction (Group III) had the highest death rate but some did well after an operative procedure.

Adult↗
PubMed1982

Ranitidine in the treatment of gastric ulceration.

Seventy-two patients with endoscopically proven gastric ulcers were entered into a prospective controlled trial to assess the efficacy of ranitidine and cimetidine in ulcer healing. All patients were biopsied on entry and at subsequent endoscopies. After exclusion of 7 patients during the first month of treatment, the remaining 65 patients, 47 males and 18 females, mean age 48.2 +/-1.5 years, at 1 month had a healing rate of 47% and 52% respectively. The non-healers continued their treatment for a further 4 weeks. This increased the healing rate to 77% and 76% respectively. If the defaulters and poor compliers are withdrawn the healing rate rises to 58% and 57% at 4 weeks and to 91% and 79% at 8 weeks respectively. There was no significant difference between the two groups as regarded initial ulcer size and severity of dyspepsia. Antacid tablet consumption during the study was comparable. The initial size of the ulcers which failed to heal after 4 weeks of treatment tended to be larger than those which healed (P less than 0.05), but smoking did not appear to influence ulcer healing. No obvious side-effects or evidence of dysplasia were found. The study shows that ranitidine is at least as effective as cimetidine in gastric ulcer healing.

Aged↗
PubMed1981

The clinical spectrum of hepatic granuloma.

Hepatic granulomas diagnosed ante mortem by liver biopsy over a 9-year period at Groote Schuur Hospital, Cape Town, were reviewed. A diagnosis was made in 94% of the 116 cases studied. Tuberculosis was found to be the cause in 50% of all cases. In Black patients tuberculosis accounted for 83%. Lymphoma was a major cause in White patients, in whom it accounted for 28%. The clinical, haematological, biochemical and radiological features favouring each diagnostic category are described. The importance of follow-up and in some cases repeat biopsy is stressed.

Female↗
PubMedDate not supplied

Limitations of percutaneous endoscopic jejunostomy.

Thirty-six patients at the University of Kentucky Medical Center underwent percutaneous endoscopic jejunostomy placement between January 1 and December 31, 1989. We retrospectively reviewed their charts for indications and complications of the procedure. Experience and outcome with the initial placement of the percutaneous jejunostomy tube was evaluated. Primary diagnoses at the time of insertion included central nervous system disorders (28), ventilator dependence (5), cancer (2), and gastroparesis (1). The follow-up period ranged from 2 to 131 days (median 16 days). Tube dysfunction or dislodgment occurred in 31% of patients. Other complications included pulmonary aspiration (11%) and bleeding at the insertion site (3%). The 30-day mortality rate was 19% with all but one death caused by the severity of the underlying primary illness. It is concluded that problems with the currently performed technique of percutaneous endoscopic jejunostomy, along with tube-related problems, seriously limit the usefulness of this technique. Improvements in technology, along with routine postprocedure radiographs to allow early detection of malpositioned jejunostomy tubes, may improve the outcome of this procedure. Newer techniques that have a higher success of distal small intestinal placement need to be evaluated.

Adolescent↗