Anaesthesia for small animal patients with disease of the hepatic, renal or gastrointestinal system.
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Biomedical subjects
Publications and source records attributed to N H Dodman.
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Debates about the advantages and limitations of animal models for psychiatric research do not usually involve behavioral disorders seen in veterinary practice. Nevertheless, naturally occurring behavioral symptoms in domestic animals may comprise important models or provide a valuable perspective for human psychiatric disorders. We review the promising but preliminary research in this area.
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Interstitial pressure and pH in the dependent biceps femoris muscle were measured in anesthetized, laterally recumbent horses. The mean (+/- standard deviation) interstitial pressure in 10 horses was 19.70 +/- 0.15 mmHg in the 30 to 180 minute interval after induction of anesthesia. Pressures of this order have been associated with reduction in muscle perfusion. Mean (+/- standard deviation) interstitial pH in six horses decreased from 7.07 +/- 0.30 to 6.73 +/- 0.21 between 45 and 150 minutes of anesthesia. These results indicated the presence of circulatory compromise to intracompartmental structures.
The incidence of post-anesthetic lameness in 655 horses undergoing 733 anesthetic episodes over a 3 year period was 6.4%. Nineteen factors previously reported or proposed to play a role in the development of post-anesthetic lameness were evaluated statistically. Only hypotension and the duration of the anesthetic period were significant factors.
Muscle surface capillary blood flow was measured in the biceps femoris and lateral head of the triceps brachii muscles in six horses before and during halothane anesthesia by using laser Doppler flowmetry. During 90 minutes of anesthesia, muscle surface capillary blood flow was reduced to 20% to 40% of preanesthetic values. Muscle surface capillary blood flow tended to be lower in dependent muscles than in nondependent muscles, and this disparity was greater in the forelimbs than in the hind limbs.
The speed of mask induction using an in-circuit vaporizer may be influenced by vaporizer setting. To investigate this in clinical patients, 18 dogs were randomly assigned to one of three groups. Each dog was premedicated and then mask induced with isoflurane using a Stephen's in-circuit vaporizer set at 1/2, 3/4, or full ON. We determined inspired isoflurane and oxygen concentrations at the level of the mask, respiratory rate, resistance to mask induction, and time to intubation. No significant differences were found between groups in resistance to induction or in time to intubation. At settings of 3/4 and full ON, inspired isoflurane concentrations at time of intubation ranged from 3.3% to 8.25%, and were significantly higher than those resulting from the 1/2 setting (range 2.1% to 4.6%). We conclude that it may be preferable to avoid settings greater than 1/2 when using the Stephen's vaporizer for mask induction because of the potential adverse effects of high inspired inhalant anesthetic concentrations. In addition, use of higher vaporizer settings may not significantly speed induction.
To learn more about predispositions for, signs, and progression of canine thunderstorm phobia, a survey for owners was posted on the Internet. Questions addressed signalment, age of onset, behavior during storms, and treatments tried. Sixty-nine responses were received. Herding dogs and herding crossbreeds accounted for the majority of dogs. Seventeen of 41 dogs with a known age of onset began exhibiting thunderstorm phobia <1 year of age. Various characteristic responses of dogs to storms were described. Improved knowledge of the demographics of thunderstorm phobia, its development, and presentation will assist in understanding the genesis and progression of the condition.