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Biomedical subjects

N Gleicher

Publications and source records attributed to N Gleicher.

At least 163 records · Page 9Linked to original sources
PubMed1985

High-dose human menopausal gonadotropin therapy for successful ovulation induction for in vitro fertilization in perimenopausal women.

Five women with elevated gonadotropin levels were treated with high doses of human menopausal gonadotropin (hMG) in order to induce an ovulatory response. Three of the five patients did not show any increase in circulating estradiol levels nor any change in the size of follicles (as observed by ultrasound), even after prolonged stimulation with up to 1200 IU of hMG. Two patients achieved an ovulatory response, however. They underwent laparoscopy with successful oocyte retrieval and fertilization. Both patients had evidence of pregnancy: one showed a transient hCG rise (chemical pregnancy), while the other continued to 12 weeks' gestational age when fetal demise was diagnosed.

Adult↗
PubMed1985

Sonographic imaging of intrauterine adhesions.

Hysterosalpingography and hysteroscopy are the diagnostic modalities most commonly used to evaluate and follow intrauterine adhesions (Asherman syndrome). Three patients with intrauterine adhesions are presented. These adhesions were visualized with sonography and appeared as dense intrauterine lines. These lines disappeared after hysteroscopic lysis of the adhesions. The present results indicate that sonography may alert the clinician to the presence of intrauterine adhesions.

Adult↗
PubMed1985

Natural killing (NK) potential of cord blood lymphocytes.

Different parameters of natural killing were evaluated in newborn cord lymphocytes using a 51Cr-release assay, a single cell cytotoxicity technique and an immuno-fluorescence method with HNK-1 monoclonal antibody. Cord blood lymphocytes expressed a positive natural killer (NK) activity although the level of this overall NK activity was lower than that of adult control (p less than 0.05). In neonates the number of cells bearing surface HNK-1 differentiation was very low (0.7 +/- 0.3). Contrary to this finding, newborns showed only a marginal decrease in the percentage of cells capable of recognizing and binding NK-sensitive target cells. However, the killing potential of these lymphocytes was impaired more profoundly (p less than 0.05) compared to adult controls. We conclude that in the neonate two distinct populations of effector cells participate in spontaneous killing. The first group is represented by classically defined NK cells (HNK-1 positive) while the second group represents. NK-like effector cells which lack the HNK-1 antigen. It seems that in newborns the latter type of cells represents the larger factor in spontaneous killing.

Adult↗
PubMed1985

Retroperitoneal pelvic lipoma.

A patient with a retroperitoneal pelvic lipoma is presented. Preoperative assessment with computed axial tomography led to the presumptive diagnosis of a fat-containing tumor. Management and differential diagnosis of retroperitoneal tumors are described.

Adult↗
PubMed1984

Cesarean section rates in the United States. The short-term failure of the National Consensus Development Conference in 1980.

The magnitude of cesarean section rates in the United States has been of increasing public concern. A consensus development conference in 1980 formulated recommendations that were expected to lead to a decrease in national cesarean section rates. A review of cesarean section patterns for the last five years in many representative states revealed, contrary to expectations, a continuing increase in cesarean section delivery rates even after the conference. A review of underlying causes for these developments suggests that only a more efficient peer review process, involving individual physicians as well as institutions, will lead to a decline of unacceptably high cesarean section rates in this country.

Cesarean Section↗
PubMed1984

Studies of natural killer cells in pregnancy. I. Analysis at the single cell level.

In using both a 51Cr-release assay and a single cell technique we measured different parameters of the effector lymphocytes killing process in pregnant and control women on a cell population and single cell level. Total NK activity was lower in pregnancy, but the difference was not significant. Parity showed no cumulative effect. Pregnant women had normal percentages of potentially cytotoxic target binding cells, however, the relative number of lymphocytes that could kill bound targets (i.e. active NK cells) was significantly depressed in pregnancy when compared with normal controls (p less than 0.05). This diminished number of active NK lymphocytes was, however, normal in all phases of the lytic procedure. Interferon (IFN) treatment of effector cells in pregnant women in vitro did not alter target cell binding, but did increase the percentage of active NK cells. The level of stimulation by IFN was the same in pregnancy and control patients. The kinetics of response were the same for both cell populations and different doses of interferon caused a similar level of augmentation. In conclusion we suggest that the here demonstrated deficiency of active NK lymphocytes in pregnancy may represent a function of pregnancy associated immunoregulatory molecules which prevent a population of pre-NK cells to express their cytotoxic potential.

Cytotoxicity, Immunologic↗
PubMed1984

Lymphocyte subsets in endometriosis.

Recent investigations suggested a possible immunologic etiology for endometriosis. To determine whether cellular immunity may be affected in patients with endometriosis, peripheral lymphocyte populations were investigated in 31 confirmed endometriosis patients and 22 control patients. No statistical differences in OKT3, OKT4, OKT8, OKM1, and OKTa1 cells could be observed. Total lymphocyte numbers were within normal ranges for both groups. Helper/suppressor ratios were not statistically different and were in a normal range for both groups. It is concluded that numeric differences in lymphocyte subpopulations represent only a very unlikely contributing factor in a potential immunologic etiology of endometriosis.

Antibodies, Monoclonal↗