Increased storage of iron and anaemia in rheumatoid arthritis: usefulness of desferrioxamine.
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Adult↗
Biomedical subjects
N Giordano
Publications and source records attributed to N Giordano.
[Plasma beta-2-microglobulin in rheumatoid arthritis].
The beta 2 microglobulin (beta 2m) is a low molecular weight protein, recognized on the cellular membranes of numerous nucleated cells and strictly correlated to the antigens of Major Histocompatibility Complex. Many authors have demonstrated an increase of the plasmatic beta 2m in different inflammatory diseases and, particularly in rheumatic ones, as Rheumatoid Arthritis (RA), Reiter's syndrome, Ankylosing Spondylitis, Systemic lupus erythematosus. We have also investigated the behaviour of the plasmatic beta 2m in 52 RA patients and in 17 healthy subjects. The beta 2m was measured in serum, by radioimmunoassay. We have demonstrated that the plasmatic beta 2m has moderately increased in the serum of RA patients, even if there is not a significant difference when compared to the normal subjects.
Adult↗
[Plasma levels of apolipoprotein and HDL-cholesterol in patients with rheumatoid arthritis].
The authors have examined the levels of the plasma cholesterol and triglycerides, of the plasma lipoproteins (HDL, LDL, VLDL) and of their main apolipoproteins (apo-A and apo-B) in a group of 64 patients affected by RA and in a population of healthy subjects considered as a contrast group, trying to establish a plausible dislipidemic factor which could justify the major occurrence of coronary heart disease in those patients suffering from RA. Statistical analysis was done with the T-test. There are not differences in the lipoprotein pattern between the group of patients affected by RA and the population of healthy subjects. The obtained result seem to exclude that such a major occurrence of coronary heart disease in the patients suffering from RA may be linked to the alteration of lipidic metabolism.
Apolipoproteins↗
[Possible mechanism of action of drugs in the basic therapy of rheumatoid arthritis: effect on platelet aggregation].
As it is known that platelets play an important role in arising and maintaining the inflammation, the authors have studied "in vitro", the effect on platelet aggregation of three drugs (Sodium Aurothiomalate, Auranofin and Penicillamine) used in basic therapy of Rheumatoid Arthritis (RA). The drugs are used in different concentrations and at different times of preincubation. The study was based on the principle of Born and using the Coagg-Salus aggregometer. The platelet aggregation was induced by ADP 2.5 microM. The authors have demonstrated that the above-named drugs inhibit the platelet aggregation induced by ADP in different percentile, according to the concentrations adopted and the time of preincubation with platelets rich plasma. This study seems particularly interesting because it can offer a possible interpretation on the mechanism of action of basic therapy in RA.
Adenosine Diphosphate↗
[Determination of the rheumatoid factor in gouty patients].
The authors have examined the incidence of the rheumatoid factor in the serum of a group of 100 patients, 95 males and 5 females, suffering from gout, of whom only 6 suffered from chronic gout. The rheumatoid factor in the serum was measured by RA-test (1:40) and by Waaler-Rose test (1:32). The rheumatoid factor was not present in the examined subjects and so we can state that such serum parameter does not represent, for its negativity, a laboratory index of any evidence in the gout and it doesn't represent a reason for diagnostic doubts with other forms with the rheumatoid factor in the serum.
Adult↗
[Determination of plasma levels of apolipoprotein E and of HDL-cholesterol in gouty patients].
The authors have examined the levels of the plasma cholesterol and triglycerides, of the plasma lipoprotein (HDL, LDL, VLDL) and of their main apolipoproteins (apo-A and apo-B) in a group of 34 patients affected by gout and in a population of healthy subjects considered as a contrast group, trying to establish a plausible dislipidemic factor which could justify the major occurrence of coronary heart disease in patients suffering from gout. Statistical analysis was done with the t-test. The group of patients affected by gout had significantly higher levels of triglycerides and VLDL-C and lower levels of HDL-C than the population of healthy subjects. The change of the lipoprotein pattern observed in the patients suffering from gout may be linked to reduction of the catabolism of the triglycerides rich lipoprotein. This reduction is probably linked to a inhibition of lipoprotein lipase.
Adult↗
[Rheumatoid cardiopathy. Observations on a clinical case].
The occurrence of cardiac involvement in RA is frequent but cardiac lesions are observed more frequently at necroscopy than on clinical examination. The case of a RA patient with a serious mitral valves involvement is reported in which the histological examination of the bioptic tissue obtained during surgical valves replacement showed a typical rheumatoid granulomatous inflammation of the endocardium.
Arthritis, Rheumatoid↗
A double-blind, interpatient comparison of plain and slow-release ketoprofen in osteoarthritis.
Eighty patients with osteoarthritis of various localization completed a double-blind, parallel-group trial of 2 weeks' duration comparing the efficacy and tolerance of ketoprofen slow-release capsules (150 mg) given either as a morning or a midday or an evening dose with that of ketoprofen conventional capsules (50 mg) 3X daily. All regimens were associated with a statistically significant improvement in pain at rest, pain on active motion, quality of sleep, and spine flexion, but there was no difference between treatments. The tolerance of ketoprofen was also similar in all groups. In view of the alleged better compliance of patients with once-daily medications, the new slow-release formulation of ketoprofen appears to be a useful alternative to the conventional capsules.
Adult↗
[Pathogenesis of ankylosing spondylitis: relation between HLA-B 27 and Klebsiella aerogenes].
The Authors attested the evidence of a cross-reactivity among some Klebsiella antigens and HLA B 27 positive lymphocytes, suggesting the hypothesis that Klebsiella may be an initiating agent in ankylosing spondylitis (AS). The Authors determined also serum antibody response against Klebsiella antigens in AS patients. The results obtained are discussed.
Adult↗
[Short-term effects of proglumetacin in arthrosis].
Proglumetacin was administered as a sole treatment during 15 days at 450 mg/day to 20 patients with osteoarthritis localized in several joints. Within the observation period, pain at rest and on loading, joint mobility and morning stiffness improved significantly. Tolerance also resulted very good, as only two patients reported mild and transient gastric upsets. The peculiar combination of good efficacy also in short-term treatment and very good tolerance, points to proglumetacin as a drug of choice for the ambulatory management also of degenerative-reactive joint disorders.
Drug Evaluation↗
Plasma cortisol variations induced in the stallion by mating.
Plasma cortisol variations have been determined by radioimmunoassay in 5 stallions during mating and in 2 teasers during oestrous female exposure. In all the animals, cortisol plasma levels consistently increase (71.1 ng/ml vs 44.0 and 63.0 ng/ml vs 35.1, in the stallions and in the teasers, respectively) 7-30 min after female exposure; 120 min after exposure, cortisol concentrations are again low.
Animals↗
A short-term, double-blind comparison between indoprofen and diclofenac in osteoarthritis.
A double-blind crossover trial was carried out in 60 patients with osteoarthritis of large joints. Patients received both indoprofen 600 mg daily and diclofenac 100 mg daily for one week without any interval between treatments. The variables investigated were: pain at rest, pain on active motion under load, quality of sleep, articular flexion and patient's preference. The assessments were made before and at the end of each treatment period. Significant improvements were found for all variables with both drugs. No significant differences were detected between the two drugs. Ten patients (6 on indoprofen and 4 on diclofenac) reported adverse reactions i.e. slight gastralgia in most cases. No withdrawals of treatment were observed.
Adult↗
Indoprofen in rheumatic patients with acute episodes: a multicentre trial.
The results are reported of an open multicentre trial in 228 rheumatic patients with flare-ups. Fourteen centres adopting the same investigational protocol collaborated in the study. Indoprofen was administered for 1 week at a daily dosage of 1000 mg according to a treatment schedule used with success in acute gouty arthritis: a 400 mg i.v. bolus was followed by 200 mg (1 tablet) t.i.d. Subjective (pain) and objective variables were used for reliable assessment of activity. Marked reduction of pain intensity was already noticeable on day 1 of treatment and was followed by progressive improvement in subjective and objective variables for all the diagnoses considered. According to the patients' own overall assessments, results were good or very good in more than 50% of cases. The best outcomes were obtained in low back pain, acute gout and psoriatic arthritis. At the end of treatment only 7.4% of patients experienced no change or deterioration of symptoms. Adverse reactions, consisting mostly of mild and reversible gastrointestinal disturbances, were reported by 9.2% of patients, but only in 1.8% was treatment discontinued. Indoprofen administered according to the above schedule is an appropriate treatment for acute episodes of rheumatic diseases.
Adolescent↗
[Apical pulmonary fibrosis in the course of ankylosing spondyloarthritis].
Two cases of an association between lung TB and ankylosing spondyloarthritis are presented. In the first case, spondyloarthritis appeared about 1 yr after fibrocavitary lesions of the LSD. The literature contains only 1 similar case, in which the gap was two years. In the second case, such lesions appeared 8 yr after spondyloarthritis. Neither patient received radiation treatment. The first received cortisone for massive joint inflammation when typical lung TB lesions were already evident. It is felt that these two additions to the literature are of interest in clarifying the delicate questions of diagnosis that arise when ankylosing spondylarthritis is accompanied by lung involvement.
Adult↗
Comparison between the analgesic and therapeutic effects of a musically modulated electromagnetic field (TAMMEF) and those of a 100 Hz electromagnetic field: blind experiment on patients suffering from cervical spondylosis or shoulder periarthritis.
The analgesic-therapeutic efficacy and tolerability of a low-frequency electromagnetic field (ELF), modulated at a frequency of 100 Hz with a sinusoidal waveform and mean induction of a few gauss, has been demonstrated by the authors in numerous previous studies of various hyperalgic pathologies, particularly of the locomotor apparatus. In the present study, the authors tested a new type of all-inclusive field, denoted TAMMEF, whose parameters (frequency, intensity, waveform) are modified in time, randomly varying within the respective ranges, so that all the possible codes can occur during a single application. For the comparison, 150 subjects (118 women and 32 men, between 37 and 66 years of age) were enrolled. They were affected by cervical spondylosis (101 cases) or shoulder periarthritis (49 cases). Unbeknownst to them, they were randomly divided into three groups of 50 subjects. One group was exposed to the new TAMMEF, another group to the usual ELF, and the third group to simulated treatment. The results show that the effects of the new TAMMEF therapy are equivalent to those obtained with the ELF.
Adult↗
Analgesic-antiinflammatory effect of a 100 Hz variable magnetic field in RA.
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Adult↗
Serum neurone-specific enolase in the primary antiphospholipid syndrome: a new biochemical marker for cerebral vascular involvement?
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Antiphospholipid Syndrome↗
[Evaluation of early biomarkers of cartilage degeneration in the diagnosis and clinico-therapeutic monitoring of primary osteoarthrosis].
It is known that in the course of osteoarthritis (OA), articular cartilage develops biochemical and structural changes. In the last years, serum and urinary markers of both the synthesis and destruction of cartilage have been dosed, above all in order to carry out an early diagnosis of OA. Among them, the urinary excretion of pyridinoline seems to correlate with the entity of the degradation of cartilage. The aim of the present study is to evaluate the above mentioned markers in OA patients compared to control subjects. Moreover, the possible influence on cartilage of two different non steroidal antiinflammatory drugs (NSAIDs), in particular Nabumetone and Piroxicam, has been verified. The study shows that the urinary excretion of pyridinoline is able to express the severity of OA. At last, the study shows that the tested drugs do not interfere with the metabolism of cartilage.
Aged↗