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Biomedical subjects

N Gingold

Publications and source records attributed to N Gingold.

35 records · Page 2Linked to original sources
PubMedDate not supplied

Ph1-positive polycythemia vera.

The rare presence of the ph1 chromosome in chronic myeloproliferative disorders other than chronic granulocytic leukemia (CGL), i.e. polycythemia vera (PV), myeloid metaplasia with myelofibrosis (MMM) and hemorrhagic thrombocytopenia (HT) raised the question whether or not the Ph1 chromosome is peculiar to CGL. In an attempt to answer this question, the authors reports six cases of positive-Ph1 of which two are from their personal experience and four from the literature. Three of these six cases converted to CGL. The authors conclude that the cases of Ph1-positive PV and HT are transition forms to CGL, and the cases of Ph1-positive MMM are in fact secondary forms derived from CGL.

Adult↗
PubMedDate not supplied

A preventive therapy of the central nervous system complications in acute leukemias. Preliminary report.

A new therapeutic schedule for preventive therapy of the central nervous system (CNS) complications by intrathecal (i.t.) injections of methotrexate (MTX) was applied in two groups of 6 and respectively 13 adults with acute lymphoblastic or non-lymphoblastic leukemias. Instead of starting this treatment only in the remission stage, i.t. MTX was given from the very beginning of cytostatic therapy. In most of the patients this drug proved to be effective in preventing CNS involvement. In some cases, however, it was not well, tolerated owing probably to a neurotoxic effect. This suggested continuation of the study with Ara-C.

Adolescent↗
PubMedDate not supplied

Detection of monoclonal gammapathies by the presence of certain peculiar changes on the Giemsa-stained blood smear.

Certain changes in the morphological and tinctorial features of the panoptically stained blood-smears suggest the diagnosis of monoclonal gammopathies in cases in which these are not even supposed. The mechanism of such alterations is discussed and emphasis is laid on the practical value of these findings in the detection of myeloma and other related syndromes in patients without clinical symptomatology or followed up for years for other diseases.

Aged↗