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Biomedical subjects

N Garti

Publications and source records attributed to N Garti.

26 records · Page 2Linked to original sources
PubMed1983

Follow-up of drug therapy efficacy to prevent recurrence of calcium oxalate kidney stone formation.

Results of a prospective study of response to phosphate treatment after surgery in a group of kidney stone formers, some of them recurrent are presented. The follow-up, of 1 year duration, was carried out by periodic tests of the stone formers' urine using the Discriminating Index (DI) procedure. In a group of 32 stone formers, 30 individuals showed a remarkable change in the DI value; i.e., the inhibiting potential of their urine was similar to that of normals. Two of the patients did not respond well, and their drug treatment was adjusted accordingly. During this year no recurrency was reported.

Calcium↗
PubMed1982

Retardation of calcium oxalate precipitation by glutamic-oxalacetic-transaminase activity.

It has been found that calcium oxalate stone formers have low UGOT activity compared to healthy individuals (controls). Urine from stone formers with no GOT activity and no effect on calcium oxalate precipitation was incubated with GOT for various periods. Subsequently calcium oxalate precipitation was decreased and found to be considerably retarded i.e., the pathological urine after the incubation acted in a way similar to that of normal urine. The yield of Glutamic-Oxalacetic Transaminase (GOT) activity is glutamic acid. It was shown that glutamic acid has a significant retardation effect on the precipitation of calcium oxalate stone formation. Therefore it may be suggested that GOT activity involved in glutamic acid creation in situ, has a role in kidney stone formation.

Aspartate Aminotransferases↗
PubMed1982

May enzyme activity in urine play a role in kidney stone formation?

It has been found that calcium oxalate stone formers have low UGOT and UGPT activity compared to healthy individuals. The urine of 23 stone formers and 19 controls has been tested for combined UGOT and UGPT activity. The effect of L-aspartic acid, alanine and L-glutamic acid on calcium oxalate precipitation has been tested. Only L-glutamic acid exerted a significant retardation effect at physiological concentrations. As GPT and GOT convert alanine and aspartic acid respectively into glutamic acid, a possible mechanism of retardation of kidney stone formation involving enzyme steps via glutamic acid creation in situ is suggested.

Alanine↗
PubMed1982

A method for discrimination between calcium oxalate kidney stone formers and normals.

Calcium ion concentration versus time was measured in solutions containing admixture of 10 per cent tested urine of normals and stone-formers, during induced calcium oxalate precipitation. A Discriminating Index was formulated by statistical analysis of the data. It was found that stone-formers and normals differ significantly with respect to the measurements and the Discriminating Indices. An equation to evaluate the odds of stone-forming based on results of an individual test has been derived. The Discrimination Index may be recommended as a diagnostic tool.

Adolescent↗
PubMed1981

Correlation between crystal habit and the composition of solvated and nonsolvated cholesterol crystals.

The correlation between the crystal habit and the composition of cholesterol crystals formed in four organic solvents (methanol, acetonitrile, ethanol, and acetone) was studied. Anhydrous and monohydrate cholesterol were precipitated in anhydrous and aqueous organic solvent mixtures, respectively. The main conclusions derived from the study were that 1) the appearance of plates does not automatically guarantee the presence of hydrated cholesterol, and 2) the presence of 5% or more of water in the crystallization solvent may not results in the formation of monohydrate cholesterol.

Acetone↗
PubMed1980

Retardation of calcium oxalate formation by polyacidic peptides.

The polycarboxylic amino acids were examined as possible retarding agents in the precipitation of calcium oxalate. The effect was observed by continuous determination of the concentration of calcium ions in a mimic urine solution. Both polyglutamic and polyaspartic acids, when used in 5 to 100 ppm concentrations, significantly retarded calcium oxalate precipitation.

Aspartic Acid↗
PubMedDate not supplied

Effect of electrolytes, stirring and surfactants in the coacervation and microencapsulation processes in presence of gelatin.

The objectives of the present study were to investigate the parameters affecting simple coacervation and the ability to encapsulate oleic acid using this technique. Coacervation has been achieved using different types of gelatin (bloom number, charge) and various electrolytes. The electrolytes used for the coacervation can be divided into three groups: (1) inert salts; (2) phase separation inducers, (a) precipitation inducing agents (PIA), and (b) coacervation inducing agents (CIA); (3) coacervation inhibiting agents. The encapsulation of oleic acid was evaluated with two types of gelatin and various emulsifiers (anionic, cationic and nonionic). For positively charged gelatin, it was found that the encapsulation is incomplete in presence of cationic emulsifiers. For negatively charged gelatin no general trend was observed. The stirring rate for each step of the preparation of the microcapsules was evaluated. It was found that high stirring is essential only in the cooling stage. The study was carried out in view of encapsulation of particular bacteria dispersed in the oil phase.

Capsules↗