[Saving the mandible in surgical treatment of mouth floor cancer].
Explore the source record for details and available documents.
Carcinoma, Squamous Cell↗
Biomedical subjects
N Gale
Publications and source records attributed to N Gale.
Epithelial-myoepithelial carcinoma of the parotid gland: a clinico-pathologic and immunohistochemical study of seven cases.
Seven cases of epithelial-myoepithelial carcinoma of the parotid gland are reported. Immunohistochemical evidence for the dual (glandular secretory and myoepithelial) differentiation of the cells composing these lesions is presented. Three of the cases recurred locally and two gave rise to metastases. The biologic behavior does not appear to be correlated with the histologic features that constitute the morphologic spectrum of epithelial-myoepithelial carcinoma.
Adult↗
Laryngeal chondrosarcoma: is conservative surgery adequate treatment?
A case of laryngeal chondrosarcoma in a 63-year-old woman is presented. The report illustrates most of the features of this rare neoplasm, the difficulties in the histopathological evaluation and supports the previous ones that recommend an initial conservative attitude towards low grade laryngeal chondrosarcomas.
Chondrosarcoma↗
Alterations in the laryngeal mucosa after exposure to asbestos.
The laryngeal mucosa of 195 workers in an asbestos cement factory (Salonit Anhovo, Yugoslavia) and in a control group was examined. The factory manufactures asbestos cement products containing about 13% of asbestos (8% amosite, 12% crocidolite, and 80% chrysotile) of different provenance. Alterations in the laryngeal mucosa were more frequent in the factory workers than in the control group. The changes, mostly consistent with chronic laryngitis, were closely related to the degree of workplace pollution and less so to the duration of employment Ten workers exhibiting the most severe clinical changes underwent biopsy, the results of which showed histomorphological changes characteristic of hyperplastic chronic laryngitis. Four tissue specimens were examined also by scanning electron microscopy and in three of them asbestos fibres were found on the epithelial surface. No case of laryngeal carcinoma was identified. On the basis of our results it is thought that asbestos related changes of the larynx should receive more attention and that the use of the term "laryngeal asbestosis" is justified. The clinical picture is non-specific but in view of their frequency such changes should be considered a consequence of exposure to asbestos.
Adult↗
[Anatomical markers of Reinke's space and the etiopathogenesis of Reinke edema].
On the basis of histological examination of normal human larynges, the authors have defined the anatomical and histological features of Reinke's space. It is sharply demarcated by dense fibrous tissue in the anterior commissure, along the vocal process of the arytenoid and beneath the free margin of the vocal cord. The upper limit is not always sharply demarcated, and on the upper surface Reinke's space varies considerably in size. It may include a half of the upper surface of the vocal cord, reaching usually to the bottom of the laryngeal ventricle and occasionally extending to include also the inferior surface of the ventricular fold. The authors suggest that the upper boundary of Reinke's space is functional. On the basis of the morphologic structure of Reinke's space a hypothesis of aetiopathogenesis of Reinke's oedema was set up. The patient's attempt to compensate the hoarseness by the use of the false vocal cords forces the fluid within Reinke's space towards the free edge of the vocal cord.
Capillaries↗
Nasopharyngeal rhabdomyoma. Report of case (light and electron microscopic studies) and review of the literature.
Rhabdomyoma is an extremely rare benign tumor originating from the skeletal or cardiac muscle cells. Only 87 cases of rhabdomyoma have been reported to date, 70% occurring in the head and neck areas. The authors present the fourth case of rhabdomyoma of the nasopharynx. The tumor appeared in an 18 year old woman with hypacusis. Examination of the epipharynx showed a 2 x 1,5 cm tumor, extending from torus tubarius down to the soft palate. Light microscopy disclosed areas and islands of polymorphous large cells with abundant eosinophilic cytoplasm. Cross striations were focally visible with special PTAH staining. Electron microscopy revealed parallel and haphazardly arranged fibrillar bands (myofibrils) with irregularly and periodically arranged densities corresponding to Z lines. The pecularities of our case were abundant cystically dilated rough endoplasmatic reticulum and the absence of cytoplasmatic glycogen.
Adolescent↗
Warty dyskeratoma of the vocal cord. First reported case.
Warty dyskeratoma is a tiny, nodular lesion with a characteristic histologic picture that resembles that of Darier's disease. Until now, these changes have been described only on the skin and the mucosa of the oral cavity. To our knowledge, our case includes the first description of this lesion on the vocal cord. This study presents clinical and histologic features in detail, dealing also with the differential diagnosis, which is very important for distinguishing the warty dyskeratoma from the squamous cell carcinoma.
Carcinoma, Squamous Cell↗
Synovial sarcoma of the soft palate in a child: a light and electron microscopic study.
An extremely rare case of synovial sarcoma localized in the soft palate of a 9-year-old boy is reported, describing all details noted during light and electron microscopic observation. All features characteristic of this mesenchymal tumour were evident in the light microscopy. Electron microscopy also confirmed the diagnosis. The text includes full particulars of the therapy administered.
Child↗
Laryngeal salivary duct carcinoma: a light and electron microscopic study.
The light microscopic and ultrastructural features of a laryngeal salivary duct carcinoma are presented. By light microscopy, the neoplasm bore a marked resemblance to the infiltrating duct carcinoma of the breast. Ultrastructurally, the tumour was characterized by the presence of two principal types of cells, i.e. epithelial and myoepithelial cells, arranged in duct-formation.
Carcinoma↗
Parotid involvement by Lennert's lymphoma.
The authors report an unusual case of Lennert's lymphoma occurring in a 65-year-old patient. The tumour involved the right parotid gland and lymph nodes of the neck. It has responded to combined treatment (radiation and chemotherapy) extremely well.
Aged↗
Intramuscular haemangioma of the middle scalene muscle.
A rare case of intramuscular haemangioma of the middle scalene muscle occurring in a young patient is described and its surgical treatment discussed.
Adult↗
Electrochemically driven biochemical reactions. II. Carbon dioxide fixation by electrochemical reduction of NADP + in chloroplast extracts.
Explore the source record for details and available documents.
Carbon Dioxide↗
Tick-borne encephalitis: possibly a fatal disease in its acute stage. PCR amplification of TBE RNA from postmortem brain tissue.
Tick-borne encephalitis has occurred regularly in Europe since it was first diagnosed in 1931 by Schneider. The mortality rate of patients with this disease is 1-2%. Death usually occurs in the acute stage of illness. A case report of a 28-year-old patient from Slovenia, who died shortly after the onset of tick-borne encephalitis, is described. The clinical course of disease, results of serological tests, neuropathological findings and polymerase chain reaction amplification of parts of viral genome from postmortem brain tissues are presented.
Acute Disease↗
Significance of keratosis and dyskeratosis for classifying hyperplastic aberrations of laryngeal mucosa.
Retrospective study of 325 tissue samples of hyperplastic aberrations of the laryngeal mucosa by means of light and electron microscopy and immunohistochemical methods has demonstrated that superficial keratinization is not important for determining changes into precancerosis or "risky epithelium" or even for the progress from hyperplastic aberrations to carcinoma. The degree of keratinization of the epithelial surface in all three forms of hyperplastic aberrations is almost the same. In grouping the hyperplastic aberrations into "precanceroses" or "risky epithelium," the following morphologic changes have to be considered as extremely important factors: the occurrence of dyskeratotic cells, the basalification of the epithelium, and the response of the organism in the form of infiltration of immunocompetent cells in the subepithelial stroma.
Adult↗
Local immune response in hyperplastic lesions of the larynx.
A retrospective morphologic and immunohistochemical study of 25 benign and 5 malignant laryngeal hyperplastic lesions was performed concerning a local immune response which might be characteristic and of prognostic value for each particular group of these alterations, using Kambic's classification, especially for precancerous and cancerous lesions. On paraffin and frozen sections, 7 monoclonal antibodies against various leukocytic antigens were used. CD43 and CD45RO T lymphocytes were the predominant cells in the infiltrates, and their frequency increased according to the degree of hyperplastic lesions. Next in frequency were CD4 cells, and a predominance of CD4 over CD8 cells was an obvious finding. The infiltration of CD68-, CD57-, and CD20-positive cells was generally weak. The intensity and composition of the local reaction in all cases of atypical hyperplasias was nearly identical, regardless of their subsequent behaviour. No apparent cytotoxic effects on the epithelial cells, either in precancerous or in cancerous lesions, were observed. Thus, the immunocompetent cells in the epithelial and stromal tissue are most likely not an effective defense in preventing hyperplastic lesions from becoming malignant. It seems that laryngeal hyperplastic lesions do not provoke an essential defense immune response, but the present local inflammatory reaction might be a constituent part of etiologically different inflammations which may lead to unfavorable lesions.
Adult↗
Lead and zinc removal by laboratory-scale constructed wetlands.
Constructed wetlands have the potential to trap and remove metals in mine wastewater. To determine the effectiveness of constructed wetlands for treating selected heavy metals in neutral mine effluent typical of lead mines, eight laboratory-scale constructed wetlands were set up to treat a synthetic, slightly alkaline, mine water containing 34.2 mg/L sulfate (SO4(2-)), 50 micrograms/L lead (Pb), and 300 micrograms/L zinc (Zn). After 45 days, one of the wetlands was switched to treat a synthetic smelter effluent with a much greater load of SO4(2-), sodium (Na+), and Pb. Temperature, hydraulic loading, and substrate composition typically did not affect treatment efficiency. The pH of the effluent was reduced from 8.0 to 8.5 to near neutral. The average removal in the eight wetlands was 90% for Pb and 72% for Zn. In wetlands operating on synthetic mine water, SO4(2-) was completely removed, likely by conversion to sulfide by sulfate-reducing bacteria. In the wetland operating on synthetic smelter effluent, only approximately 25% of 6 g/L influent sulfate was removed, and a breakthrough period of 4 days for Na+ was observed. Whole effluent toxicity assays on undiluted wetland effluent from wetlands treating mine and smelter water had 100% survival of fathead minnows and Daphnia magnia. Survival of Ceriodaphnia dubia was zero in undiluted effluent, but 75 to 100% survival was observed when the effluent was diluted to one-half strength.
Animals↗
Expression of tenascin and fibronectin in benign epithelial hyperplastic lesions and squamous carcinoma of the larynx.
BACKGROUND: Tenascin (T) and fibronectin (FN) are glycoprotein components of the extracellular matrix presumably involved in cancer progression. We analyzed their expression in epithelial hyperplastic lesions (EHL) and squamous carcinoma (SC) of the larynx. MATERIALS AND METHODS: Samples from resected larynges of 30 patients with SC, and laryngeal biopsies of 28 patients with EHL, SC or benign reactive conditions were included. Immunohistochemistry was performed with antibodies against T and FN. RESULTS: T and FN gradually increased with the grade of EHL and were markedly increased in the majority of SC. In SC, expression of T and FN correlated with the degree of desmoplasia but was inversely related to the density of lymphocytic stromal infiltration and the differentiation of SC. T and FN were also positive in benign reactive conditions. CONCLUSION: T and FN immunostaining provides useful information on epithelial-stromal interaction in laryngeal EHL and SC but should not be regarded as a reliable stromal marker of malignancy. Our results supported the postulated diversified nature of the tumor stroma.
Adult↗
Quantitative measurement of telomerase catalytic subunit (hTERT) mRNA in laryngeal squamous cell carcinomas.
We tested 30 laryngeal squamous cell carcinomas (LSCCs) and 30 matched control laryngeal samples from the same patients for the presence of human telomerase catalytic subunit (hTERT) mRNA by using the Roche LightCycler Telo TAGGG hTERT Quantification kit. The hTERT index was calculated to express the relative quantity levels of hTERT mRNA. hTERT mRNA was detectable in 10 out of 30 (33%) laryngeal tissues covered by normal and/or reactively hyperplastic laryngeal epithelium and 23 out of 30 LSCCs (77%). The mean hTERT indices were 0.15 for control non-cancerous laryngeal samples, 0.57 for grade I, 2.35 for grade II and 3.72 for grade III LSCCs. LSCCs without detectable hTERT mRNA (23%) tended to have lower grades of disease. No correlation was found between the levels of hTERT mRNA and tumour size or locoregional lymph node status. We believe that hTERT mRNA in normal and/or reactively hyperplastic laryngeal epithelium originates from the stem cells and corresponds to the self-renewal capacity of the squamous epithelium. However, the greater quantity of h TERT mRNA in LSCCs is the result of telomerase reactivation in the process of laryngeal carcinogenesis.
Adult↗