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Biomedical subjects

N Gagic

Publications and source records attributed to N Gagic.

8 recordsLinked to original sources

Open cholecystectomy: muscle splitting versus muscle dividing incision: a randomized study.

While laparoscopic cholecystectomy has become the standard procedure for symptomatic gallstones, it is likely that 10% of patients will require an open cholecystectomy whether owing to contraindications to the laparoscopic approach or because conversion to the open technique became necessary following laparoscopy. Although the trend towards smaller open cholecystectomy incisions has led to a reduced hospital stay, much of the postoperative morbidity can be ascribed to wound pain. Muscle splitting incisions tend to be less painful than muscle dividing incisions. This randomized consecutive study of elective and emergent open cholecystectomies compared a muscle splitting incision with the traditional muscle dividing technique. The muscle splitting technique was significantly (P < 0.001) less painful than the muscle dividing method as evaluated by the short form of the McGill pain questionnaire. Similarly, a significantly greater proportion of patients were fully mobile on the first and second postoperative day in the muscle splitting group compared with the muscle dividing group. Analgesia requirements, however, were not statistically significant between the two groups. We recommend that when open cholecystectomy is necessary the muscle splitting technique should be employed.

Analgesia↗

Toxic megacolon associated with anticancer chemotherapy.

The majority of gastrointestinal side effects associated with anticancer chemotherapy are relatively mild and self-limiting and can be managed empirically. However, severe side effects, such as necrotizing enterocolitis and ischemic colitis, sometimes do occur after chemotherapy. The authors present a case of toxic megacolon associated with anticancer chemotherapy. This is a relatively uncommon but potentially lethal complication of ulcerative colitis.

Adult↗

Intraperitoneal prolene mesh in hernia repair: a comparison of two techniques.

Prolene (polypropylene) mesh is a useful material for technically difficult repairs of abdominal wall hernias. In this study, two insertion techniques were used and compared. The first method, in which 2-cm wide strips of mesh were cut perpendicular to the main part, pulled through the musculoperitoneal layer and anchored to the anterior fascial layer, was abandoned after use in 10 patients because of complications. The second method, using circumferential horizontal mattress sutures to anchor the mesh, gave satisfactory results in the 40 patients in whom it was used. There were no deaths, and complications were few and easily dealt with.

Female↗

The results of cholecystostomy for the treatment of acute cholecystitis.

Six of 22 patients with acute cholecystitis who had a cholecystosomy died. All six deaths were attributed to cholangitis, none of the patients had undergone common bile duct decompression at the time of cholecystosomy. Cholecystostomy must be accompanied by choledochotomy in the treatment of acute suppurative cholangitis. Cholecystostomy is a safe procedure, can be performed rapidly, and is recommended in a select group of patients with acute cholangitis without jaundice or for clinical signs of cholangitis.

Aged↗

Acute cholecystitis.

The mortality rate for acute cholecystitis was 9.4 per cent. Those patients who underwent cholecystostomy had a mortality rate of 27.3 per cent, cholecystectomy 2.2 per cent, cholecystectomy and choledochotomy 7.4 per cent. Factors found to have an adverse effect on mortality in acute cholecystitis included sphincterotomy, perforation or gangrene of the gallbladder and cholagitis. Cholecystectomy is the operation of choice in acute cholecystitis in the absence of or history of jaundice or evidence of a common duct stone or cholangitis. Operative cholangiography and pressure and flow measurements through the cystic duct are advocated to avoid a retained common duct stone. Cholecystostomy should be reserved for the critically ill patient or a patient who deteriorates during operation, and it should be done only if the operator visualizes clear bile returning through the cystic duct.

Acute Disease↗