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Biomedical subjects

N G Smart

Publications and source records attributed to N G Smart.

8 recordsLinked to original sources
PubMed1995

Evaluation of an amethocaine gel preparation for percutaneous analgesia before venous cannulation in children.

We have evaluated the efficacy and safety of a preparation of 4% amethocaine gel in alleviating the pain of venous cannulation in children. In an initial open study of 148 children, clinically acceptable anaesthesia was achieved in 92% of cases. The preparation was then compared with 5% EMLA cream in a single-blind study in 94 patients using an application time of 40 min. We found clinically acceptable conditions in 85% of patients receiving amethocaine gel compared with 66% in the EMLA group. There were no significant adverse effects noted in each group, although 37% of those children treated with amethocaine gel showed localized erythema at the application site. The results suggest that amethocaine gel has greater efficacy and a faster onset time than EMLA cream when used for this purpose in children.

Administration, Cutaneous↗
PubMed1991

Extradural opioids.

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Anesthesia, Epidural↗
PubMed1991

The functional deadspace of needle-free injection ports.

This study examined six needle-free injection ports comprising three taps (Sorenson Intralock, Top type L, Viggo Connecta), a one-way valve (Braun RV 1000) and two cannulae with integral injection ports (Vasofix, Venflon 2) with regard to deadspace, protection against blood spillage, and potential difficulties in use. A conventional bung (Baxter), requiring needle use for drug administration, was included for comparison. Where necessary, ports were combined with cannulae in order to simulate clinical practice and allow fair comparison with the Vasofix and Venflon cannulae. Total deadspace was then calculated by filling with normal saline and measuring weight increase. Deadspace (0.10 to 0.43 ml) varied with injection port type and cannula size. Such volumes can contain significant amounts of drug and may be hazardous if not flushed after injection. Only the Vasofix and Venflon Cannulae and the Braun RV1000 protected adequately against blood spillage. Costs varied widely (A$0.19 to A$2.20 excluding cannula). The Vasofix and Venflon 2 cannulae were found to be nearest the ideal.

Catheterization, Peripheral↗
PubMed1991

Epidural LA/opioid.

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Analgesia, Epidural↗
PubMed1983

The effect of clonidine on the response to stimulation of non-adrenergic non-cholinergic nerves in the guinea-pig urinary bladder in-vitro.

The effects of clonidine on the response of the guinea-pig urinary bladder detrusor muscle to stimulation of non-adrenergic non-cholinergic (NANC) nerves were investigated in-vitro. In tissues from both treated and chemically sympathectomized animals, in the presence of atropine (10(-5) M) to inhibit cholinergic responses, clonidine (10(-10)-10(-6) M) invariably enhanced the contractile response to NANC nerve stimulation at 2, 5, 10 and 20 Hz. The enhancement was not inhibited by yohimbine (10(-5) M), phentolamine (10(-5) M), or the histamine H1- or H2-receptor antagonists mepyramine (10(-6) M) or cimetidine (10(-5) M) respectively. Phentolamine (10(-5) M), like clonidine, enhanced the response to stimulation of NANC nerves at 2, 5, 10 and 20 Hz. Xylazine, another alpha 2-agonist, which, unlike both clonidine and phentolamine, is not a substituted 2-imidazoline compound, failed to enhance the response in the bladder to NANC nerve stimulation. The results suggest that clonidine enhances the response to NANC nerve stimulation, independently of its effects on alpha-adrenoceptors, by increasing the amount of NANC transmitter available.

Adenosine Triphosphate↗