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Biomedical subjects

N G Guseva

Publications and source records attributed to N G Guseva.

At least 55 records · Page 3Linked to original sources
PubMed1990

[New markers of collagen and basal membrane metabolism and kidney involvement in systemic scleroderma].

The study was made within the framework of the Soviet-Finnish cooperation and represents a fragment of work pertaining to the clinical trials of new markers of metabolism of collagen and basal membranes in patients afflicted with systemic scleroderma (SSD). Sufficient clinical material (84 SSD patients) and radioimmunoassays were employed to study the clinical significance of aminoterminal propeptide of type III procollagen. In SSD patients with renal impairment (n = 34) and without it, PIIINP and PIIINP-Fab, serum galactosyl hydroxylysylglucosyltransferase and two antigens of basal membranes-7S-domene of type IV collagen and PI-fragment of laminine were determined. Renal impairment was established to correlate with serum concentration of PIIINP-Fab (p less than 0.007). PI-fragment of laminine. The parameters under study correlated as well with the disease course, the presence of arthritis and the Raynaud's syndrome gravity and can be regarded as markers of the disease activity and high fibrous formation lying at the basis of SSD.

Adolescent↗
PubMed1989

[Heterogeneity of the immune response to antigens of the muscular and interstitial connective tissue of the heart in patients with rheumatic diseases. I. Age factors and specificity to alpha-galactose].

Antibodies (Ab) reacting with the myocardial sarcolemma (SL) and interstitial connective tissue (ICT) were determined in 1333 rheumatic disease (RD) patients and in 286 healthy subjects of various age using indirect immunofluorescence technique. The age-related levels of SL and ICT Ab are responsible for the heterogeneous immune response to SL and ICT antigens. The presence of SL Ab is characteristic for young patients, of ICT Ab, for older patients. Children are found to have ICT Ab more infrequently, Sl Ab are more common in rheumatism than in other rheumatic diseases. The higher inflammatory process activity is associated with a more frequent presence of SL Ab and rare ICT Ab in each age group. In RD patients, SL Ab are considered to be risk factor of cardiac disease development. The ICT antigen is found to incorporate alpha-galactose. The reasons for the absence of ICT Ab in the healthy young and in patients with maximum inflammation are discussed.

Adolescent↗
PubMed1989

[A working classification and nomenclature of rheumatic diseases (pediatric aspects)].

The authors provide the working classification of rheumatic diseases prepared by a large group of scientists under the aegis of the All-Union Society of Rheumatologists and under the guidance of V. A. Nasonova, Academician of the USSR AMS. In preparing the final variant of the classification use was made of the experience gained by therapists in cooperation with pediatricians.

Adolescent↗
PubMed1989

[Analysis of the distribution of class I HLA-antigens in patients with systemic scleroderma with regard to features of the clinical course of the disease and therapy with D-penicillamine].

The distribution of HLA-A, B, C antigens has been studied in 40 patients with systemic scleroderma and in 200 healthy individuals (all Russians). An increased frequency of the antigens B35 and Cw4 has been discovered in patients, as compared with control. When analysing different clinical and common parameters, lung affection in the systemic scleroderma patients was found to be associated with the antigen A10 (58.9% versus 21% in control, RR = 5.22, EF = 0.476, Pc = 0.0363), the presence of antinuclear antibodies being associated with the antigen B35 (50% versus 17% in control, RR = 4.8, EF = 0.396, Pc = 0.0354). The association with the antigen B8 most commonly mentioned in the literature was characteristic of the patients with an earlier onset of the disease (under 30 years) and those with the rheumatoid factor. The patients having D-penicillamine-induced complications were found to have an increased frequency of the antigen B8, as compared with the alternative group of patients (2P = 0.0430).

Adolescent↗
PubMed1988

[Sjögren's syndrome in systemic scleroderma].

Combined investigation of 43 patients with sclerodermia systematica (SSD) was conducted to detect Sjogren's syndrome (SS) and to study SSD association with SS. Four groups of patients were defined: with marked SS (10), primary SS (12), probable SS (13), and without SS manifestations (8). Comparative characterization has shown that SS is detected slightly more frequently in a chronic course of SSD, combines with manifestations of sclerodactyly, telangiectasia, calcinosis, however esophageal hypomobility, indurative skin changes and contractures which are typical of SSD, occur less frequently than in SSD patients without SS. SSD association with SS is characterized by polyarthralgia, arthritis, marked Raynaud's syndrome, the frequency and rather high RF titers, the detection of anti-Ro and anti-La, and a significant rise of the level of circulating immune complexes determined by SS influence. SS manifestations in SSD are retention pains in the parotid glands, signs of clearness on sialograms, periductal sclerosis in the form of rings in morphological investigation of the parotid glands.

Adult↗
PubMed1987

[Treatment of Raynaud's syndrome with calcium entry blockers].

The authors have presented the results of a 14-day open randomized trial of the efficacy of 3 calcium inlet blocking agents: nifedipine, verapamil and phendilin in 61 patients with Raynaud's syndrome. In the group of patients receiving 30-80 mg of nifedipine (20) there was a significant decrease in the frequency and expression of Raynaud's syndrome attacks, a positive effect of varying degree was noted in 19 patients. The drug raised slightly the skin and muscular blood flow and skin temperature. The use of 120-360 mg of verapamil in 21 patients caused no significant inhibition of Raynaud's syndrome and rise of hemocirculation. Phendilin (150-300 mg) though being comparable with nifedipine in efficacy, often produced side-effects resulting in the drug cancellation (8 out of 20). The efficacy of the calcium inlet blocking agents, especially nifedipine, for therapy of Raynaud's syndrome was emphasized.

Adolescent↗
PubMed1987

[The sclerodermatous group of diseases].

The paper is concerned with the author's considerations on a sclerodermic group of diseases including a wide spectrum of diseases with systemic or local "primary" fibrosis on the basis of the results of her own investigations and the literature data. Multifactorial genesis of diseases, cellular mechanisms and the interrelationship of fibrosis with immune and microcirculatory disturbances are discussed with regard to sclerodermia systematic. Recently defined, hitherto unknown diseases and syndromes were described: diffuse eosinophilic fasciitis, the paraneoplastic sclerodermic syndrome "induced" sclerodermia, local fibroses. An analysis of the sclerodermic group of diseases and the chief mechanisms of their development is important for improved diagnosis and development of effective programs of pathogenetic therapy, prevention and mass screening.

Adult↗
PubMed1986

[Antinuclear antibodies in Sjögren's disease and syndrome].

A study was made of the presence of antinuclear antibodies to Ro, La, nDNA, RNP and Sm in 18 patients with Sjögren's disease (SD) and in 13 patients with Sjögren's syndrome (SS). Anti-Ro and/or anti-La were revealed in 12 SD patients (67%) and in 3 SS patients (23%, P less than 0.05) only. Anti-nDNA and anti-RNP were detected in 39 and 15% of the SS patients respectively and were undetectable in the SD patients. Anti-Ro and/or anti-La were detected in all SD patients, III degree activity, and associated with the presence of Raynaud's syndrome, recurring nonerosive arthritis and the absence of adequate therapy. Anti-Ro only were detected in 44% of the SD patients only and in none of the SS patients. Higher values of ESR, RF and CIC were revealed in the SD patients with anti-La and especially anti-Ro.

Adolescent↗
PubMed1986

[Microcirculatory disorders in the genesis of sclerodermic nephropathy].

Biomicroscopy of the vessels of the conjunctiva (BMV), the determination of erythrocyte and platelet aggregation capacity and investigations of the effective cutaneous and muscular blood flow and blood plasma renin activity were employed to study microcirculation in 110 patients with systemic sclerodermia (SSD) (74 with and 36 without renal lesion). The detected disturbances were correlated with the nature and gravity of sclerodermic nephropathy (SN). In BMV the frequency of intravascular platelet aggregation increased with a rise of the gravity of renal pathology. The quantitative determination of erythrocyte and platelet aggregation capacity revealed a significant acceleration of the aggregation of the blood cell elements in the SSD patients which correlated with SN presence and gravity as well as with renal function indices. Renin plasma activity was significantly raised in patients with severe renal pathology. There was correlation between the indices of function of the kidneys and ultrastructural signs of lesion of their microcirculatory bed. The results of the study served as a basis for the differential use of vascular drugs and the development of new pharmacotherapeutic methods for SSD patients with renal lesion.

Adolescent↗
PubMed1986

[Clinical aspects and diagnosis of diffuse eosinophilic fasciitis].

The authors presented an analysis of 10 cases of eosinophilic fasciitis (EF): 6 men and 4 women aged 18 to 55. In 4 patients the disease followed excessive physical exercise. Pronounced induration of the limb tissues with the development of flexion contractures, hypereosinophilia prevailed in the clinical picture of the disease, morphology showed a picture of fasciitis. A positive time course was noted in the presence of corticosteroid therapy which in 2 patients was combined with azathioprine and carbohemoperfusion. Besides, there was a patient with the combination of the classical signs of scleredema and EF. EF appears to be a nosological entity. The probability of combined forms requires a further study.

Adolescent↗
PubMed1986

[Echocardiographic study of heart function in systemic scleroderma].

Echocardiographic investigation of 65 patients with systemic scleroderma showed that the left ventricular sizes and indices of central hemodynamics were frequently lowered in them; an increase in sizes was observed mainly in the patients with stage II-III of disease. In 3/4 of the same patients pericarditis was revealed; on the whole, it was detected in 26 (40%) examinees. One patient had changes which were typical of asymmetric obstructive cardiopathy. In location of the valvular apparatus signs of mitral stenosis were found in one patient, those of mitral insufficiency in one patient and those of aortic insufficiency in one patient. Signs of mitral prolapse were noted in 7 (10.9%) patients, i.e. twice more frequently than in the entire population. Echocardiography made it possible to specify the nature of cardiac pathology and brought to light some additional features of the involvement of different heart membranes in systemic scleroderma.

Adolescent↗