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Biomedical subjects

N G Georgiade

Publications and source records attributed to N G Georgiade.

At least 37 records · Page 2Linked to original sources
PubMed1981

Recurrent ameloblastoma in autogenous rib graft. Report of a case.

Recurrent tumors in previously placed bone grafts are rare. A case of recurrent ameloblastoma in a rib graft 13 years after resection and reconstruction is presented. A review of the literature discloses only one cases of ameloblastoma recurring within a bone graft. Considering that the recurrence rate is substantial in these tumors, prudent planning and meticulous surgery is mandatory prior to any attempt at reconstruction to minimize the risk of failure due to recurrence.

Aged↗
PubMed1981

Modified radical mastectomy with immediate reconstruction for carcinoma of the breast.

Fifty patients undergoing immediate reconstruction of the breast following modified radical mastectomy for carcinoma were characterized by their clinical findings and the pathologic features of their tumors. Evidence of nipple--areolar involvement by tumor was noted in five patients. This high incidence mitigates against nipple--areolar transplantation. In ten patients the breast contained multifocal tumor or intraductal carcinoma away from the primary tumor, thus emphasizing the importance of careful evaluation of the total tissue specimens. Four patients have had recurrence of tumor. The detection of the recurrence was not hindered by the presence of the prosthesis. In these four patients immediate reconstruction of the breast did not appear to adversely affect the natural history of the breast cancer. We suggest that when appropriate and thorough surgical extirpation followed by reconstruction is undertaken as a team effort among the general and plastic surgeons, pathologist and clinical psychologist, the optimal clinical and cosmetic results may be achieved. However, conclusive statements regarding the long-term implications of immediate reconstruction awaits additional follow-up.

Adult↗
PubMed1981

The correlation of histologic changes in the human breast with the menstrual cycle.

Histologic changes in the normal human mammary gland associated with the menstrual cycle were sought in tissues derived from a defined population of patients undergoing subcutaneous mastectomy or reduction mammoplasty for reasons other than neoplasia. Ninety patients were selected for their regular menstrual cycling, abstinence from hormone use, and absence of disease which might influence pituitary-ovarian cycling. Morphologic changes in the mammary stromal and epithelial components were identified as they related to specific pituitary-ovarian events, and histologic criteria were identified that allowed reproducible morphologic categorization of the mammary gland into five specific phases: proliferative (Days 3-7); follicular phase of differentiation (Days 8-14); luteal phase of differentiation (Days 15-20); secretory (Days 21-27); and menstrual (Days 28-2). Double-blind reviews of tissues confirmed the validity and the reproducibility of these histologic criteria in identifying the menstrual phase. The findings further characterize the morphologic correlates of hormone responsiveness of the normal human mammary gland. The recognition of menstrual-cycle-dependent histologic changes may be expected to provide a basis for extending the interpretation of the morphologic characteristics of the breast in surgically acquired specimens that may be associated with hormonal aberrations.

Adolescent↗
PubMed1980

Breast reconstruction following mastectomy: I. Social characteristics of patients seeking the procedure.

Information is presented from a clinical study of 65 women and a psychometric study of 85 women having breast reconstruction following mastectomy for breast cancer. The average woman was in her midforties. Less than a third of the women described themselves as fulltime housewives; most were employed outside the home. Almost all had completed high school and most had received additional education. Most of the women were married when they sought breast reconstruction. The time at which women had had their mastectomies was related to their source of information about breast reconstruction. When more than five years had elapsed between mastectomy and reconstruction, a woman most often had obtained her information from the media. Women with more recent mastectomies, though utilizing the media, obtained their information more frequently from medical sources.

Adult↗
PubMed1980

Breast reconstruction following mastectomy: II. Marital characteristics of patients seeking the procedure.

Information is presented from a clinical study of 65 women and a psychometric study of 85 women. All had had mastectomies because of breast cancer and were reconstruction patients at Duke Hospital. Women seeking breast reconstruction did not exhibit characterological problems. Relatively few were in psychiatric treatment, and previous research had established the presence of positive rather than negative self-images. The marriages of women seeking this surgical procedure were positively and the women viewed their marriages as a chief source of support. Considerable satisfaction was expressed about husbands being supportive, although husbands were also viewed as poor listeners and, at times, as unable to communicate effectively. Most women were satisfied with various aspects of their sexual lives. A small percentage of the women reported problematic marriages. Various factors, related to the presence of conflict in the marriage and the ability of the husband to understand his wife, may account for the distress evidenced in these marriages. Such factors, of course, are present in any problematic marriage; it remains to be demonstrated whether these problems were caused or exacerbated by the woman's mastectomy and decision to seek breast reconstruction.

Adaptation, Psychological↗
PubMed1980

Reconstruction of the lower extremity with vascularized composite tissue: improved tissue survival and specific indications.

A retrospective assessment of 50 vascularized composite tissue transfers was carried out with 48 patients. Factors responsible for improved tissue survival included (1) the evaluation and proper selection of recipient vasculature, (2) the increased dependence on the vacularized latissimus dorsi musculocutaneous flap, and (3) the frequent use, wherever possible, of an end-to-side arterial anastomisis. Specific indications for reconstruction of the lower extremity with vascularized composite tissue include (1) avulsive injuries to the distal tibia and foot, (2) the failure of conventional methods, (3) the treatment of extensive chronic osteomyelitis, (4) deficiency of both soft tissue cover and skeletal support, (5) the restoration of form and contour with minimal secondary deformity of the donor site, and (6) extensive loss of soft tissue only. Reconstruction of the lower extremity with vascularized tissue is a reliable method with acceptable patient and tissue morbidity statistics that should be considered when specific indications are present.

Amputation, Traumatic↗
PubMed1980

Vascularized rib-periosteal and osteocutaneous reconstruction of the maxilla and mandible: an assessment.

Three approaches to provide rib-periosteal or osteocutaneous composite tissue in maxillary or mandibular reconstruction are presented. All methods appear to be useful in replacing viable osteocytes and improving vascularity of maxillary or mandibular defects. Disadvantages include the bulk of the transplanted tissue, volume deficiency of bone, and the unreliability in viability of the associated cutaneous tissue, especially with the posterior and posterolateral approach. Significant patient morbidity and pulmonary complications in our series should indicate caution when considering these methods of reconstruction. At present, rib-periosteal transplantation is most often indicated to replace segmental defects of mandibular continuity when the recipient bed is avascular but the quantity of cutaneous cover is adequate. In those patients with deficient soft tissue and a small segmental mandibular loss, reconstruction with musculocutaneous flaps and nonvascularized bone grafts is indicated. With extensive deficiencies of both soft tissue cover and mandibular or maxillary continuity, an iliac osteocutaneous flap based on the deep circumflex iliac vessels may be the most effective. Lower patient morbidity statistics should be anticipated.

Evaluation Studies as Topic↗
PubMed1980

Selection of patients for heterotopic implantation of the areola and nipple.

In a prospective analysis of 291 specimens taken at mastectomy for carcinoma, 48 contained tumor in the nipple-areola complex. The characteristics of greater tumor size, higher frequency of lymph node involvement, midbreast tumor location and multifocality of tumor correlated well with the probability of involvement of the nipple. The findings emphasize the importance of close clinical and histopathologic examination of the nipple and areola when preservation of the nipple is being considered.

Adult↗
PubMed1979

Plastic surgery.

Explore the source record for details and available documents.

Facial Injuries↗
PubMed1979

Reduction mammaplasty utilizing an inferior pedicle nipple-areolar flap.

A technique utilizing the inferiorly based dermal pedicle nipple-areolar flap is described. The advantages of this technique are:(1) predictable breast shape based on preoperative markings; (2) direct visibility of all areas for ease of resection and hemostasis; (3) retention of normal nipple duct connections; (4) no impairment of subjective sensation; and (5) adequate blood supply. This technique has particular application in younger women, in whom nipple sensation is quite important. The interruption of the intercostal nerve branches is usually limited because of the thickness and width of the inferior pedicles. Utilizing our modifications of the technique originally described, this versatile flap can now be used routinely in reduction mammaplasties requiring the removal of either small amounts (200 gm) or quite large amounts (2,500 gm) of tissue with consistently satisfactory aesthetic results and excellent patient satisfaction.

Adult↗
PubMed1979

Is there a reduction mammaplasty for "all seasons?".

No technique will serve the needs of all patients requiring a reduction mammaplasty and mastopexy. However, the modified, inferiorly-based dermal flap technique appears to us to offer the most advantages and the greatest latitude for a predictable breast reduction in most of these patients.

Adolescent↗
PubMed1979

Late development of hematoma around a breast implant, necessitating removal.

We present a patient who bled into the pocket around a breast implant 2 1/2 years after an augmentation mammaplasty. She had received inflatible silicone prostheses, each containing 40 mg of triamcinolone acetonide. Our belief is that this large dosage of corticosteroid was responsible for the late erosion of the medium-sized artery, which caused the hemorrhage. Exploration and evacuation of the hematoma was followed by an uneventful postoperative course.

Adult↗
PubMed1978

Microsurgical composite tissue transplantation.

Since 1974, 69 patients with extensive defects have undergone reconstruction by microsurgical composite tissue transplantation. Using this method, donor composite tissue is isolated on its blood supply, removed to a distant recipient site, and the continuity of blood flow re-established by microvascular anastomoses. In this series, 56 patients (81%) were completely successful. There have been eight (12%) failures, primarily in the extremities. There have been five (7%) partial successes, (i.e., a microvascular flap in which a portion was lost requiring a secondary procedure such as a split thickness graft). In those patients with a severely injured lower extremity, the failure rate was the greatest. Most of these were arterial (six of seven). These failures occurred early in the series and were thought to be related to a severely damaged recipient vasculature. This problem has been circumvented by an autogenous interpositional vein graft, permitting more mobility of flap placement. In the upper extremity, all but one case were successful. Early motion was permitted, preventing joint capsular contractures and loss of function. Twenty-three cases in the head and neck region were successful (one partial success). This included two composite rib grafts to the mandible. Prolonged delays in reconstruction following extirpation of a malignancy were avoided. A rapid return to society following complete reconstruction was ensured. Nine patients presented for reconstruction of the breast and thorax following radical mastectomy. All were successfully reconstructed with this new technique except one patient. Its many advantages include immediate reconstruction without delayed procedures and no secondary deformity of the donor site. Healthy, well vascularized tissue can now be transferred to a previously irradiated area with no tissue loss. This new method offers many advantages to older methods of reconstruction. Length of hospital stay and immobilization are reduced. The total number of operative procedures required in achieving the desired result is also less, thus decreasing the cost of hospital care.

Arm↗
PubMed1978

Use of the latissimus dorsi myocutaneous island flap for reconstruction in the head and neck area: case report.

Cadaver dissection indicated that a large amount of tissue could be transferred in one stage to the head and neck by a latissimus dorsi myocutaneous island flap tunneled beneath a pectoral skin bridge. A clinical trial of this flap (for one-stage reconstruction of a patient after excision of a recurrent mandibular carcinoma and a neck dissection) was successful. Previous investigators have found the myocutaneous latissimus dorsi flap to be dependable and adaptable in reconstructions of the chest wall, breast, and shoulder. It is evident now that the flap also has value in reconstructions of the head and neck.

Carcinoma, Squamous Cell↗
PubMed1978

Transfer of free flaps to provide well-vascularized, thick cover for breast reconstructions after radical mastectomy.

The use of a free flap to bring in well-vascularized cover for a breast reconstruction (following radical mastectomy) is presented. Eleven of 12 such transfers were successful. (One free groin glap failed, and that reconstruction was abandoned.) Patients for breast reconstruction who have a marked deficiency of healthy, well-vascularized skin and subcutaneous tissue in the area are suitable candidates for this operative procedure. When a free groin flap is transferred, the donor defect is minimal.

Axilla↗