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Biomedical subjects

N Friedman

Publications and source records attributed to N Friedman.

108 records · Page 6Linked to original sources
PubMed1977

Migraine: fusional-eye movement stress.

This paper indicates that the sources of migraine have always been in doubt, from ancient times when physicians first described the syndrome of migraine without clarifying it sources to the present day when physicians, still in some doubt, contend that excess of such substances as acetylcholine or serotonin may trigger the migraine. This paper argues that dynamic binocular seeing, normally a stress function, excites the migraine headache, primarily, howver, among visual pain sensitive individuals. Cases are offered whose migraine is relieved by creating a finer binocular seeing balance through fusion-eye movement training with the V.T. Reading Aid.

Accommodation, Ocular↗
PubMed1969

Biological activity of 5-hydroxymethyluracil and its deoxynucleoside in noninfected and phage-infected Bacillus subtilis.

(14)C-hydroxymethyldeoxyuridine (dHMU) is specifically incorporated into the deoxyribonucleic acid (DNA) of bacteriophage SP8. Incorporation experiments demonstrate that the initiation of phage SP8 DNA synthesis occurs between 12.5 to 15 min after infection. Incorporation into host DNA does not occur. (14)C-dHMU can be used as an analytical tool for screening conditionally lethal phage mutants containing hydroxymethyluracil in their DNA to select those that are defective in DNA synthesis under restrictive conditions. The pyrimidine, (14)C-hydroxymethyluracil (HMU), is not incorporated into bacterial or phage DNA. Neither HMU nor dHMU can replace thymine as a growth requirement for Bacillus subtilis 168 Ind(-) Thy(-). HMU does not inhibit the utilization of thymine. Although dHMU inhibits deoxythymidine utilization, the inhibition is not competitive.

Bacillus subtilis↗
PubMedDate not supplied

Clinical, genetic and histopathologic findings in two siblings with muscle-eye-brain disease.

PURPOSE: We present the clinical, genetic and histopathologic findings in two siblings with Muscle-Eye-Brain Disease (MEB-D), an autosomal recessive disease characterized by mental retardation, muscular dystrophy, retinal hypoplasia and brain abnormalities. METHODS: Clinical, histopathologic and gene mapping studies of a family with two normal and two children with MEB-D. RESULTS: Two siblings presented in the first few months of life with developmental delay, hypotonia, and strabismus. MRI of the brain showed colpocephaly, pontine and cerebellar atrophy, and diffuse white matter disease. Both patients were blind and had high myopia, strabismus, and retinal and optic nerve abnormalities. The older boy had glaucoma. Both children died from uncontrolled seizures. There was retinal, choroidal and RPE atrophy and optic nerve hypoplasia on ocular histopathology. Both patients shared the same parental haplotypes at the MEB locus on chromosome 1p, while an unaffected sibling did not, indicating possible linkage to the MEB locus. CONCLUSIONS: Patients with MEB-D have severe visual impairment from retinal and optic nerve hypoplasia. High myopia appears to be a consistent finding. The ocular manifestations of MEB-D appear to be distinct from those of patients with Walker-Warburg syndrome.

Abnormalities, Multiple↗
PubMedDate not supplied

The effects of irradiation on breast cancer and the breast.

The pathologic changes in tissues from 100 women who had received radiation therapy for breast cancer were studied. It is concluded that carcinoma of the breast cannot be considered a radiosensitive tumor, that irradiation should not be considered conservative treatment, and that radiotherapy is not innocuous. More studies of post-irradiation breasts are needed, from biopsy, surgical, and autopsy specimens. These studies should evaluate the tissues for the presence or absence of tumor, for radiation changes in the breast and the tumor, for evidence of tumor regression, for multicentricity, and for histologic types and patterns. Until this is done, the final results of radiation therapy for carcinoma of the breast will remain unknown.

Breast↗