Biomedical subjects
N Freymond
Publications and source records attributed to N Freymond.
[Aspergillus bronchitis and aspergilloma treated successfully with voriconazole].
INTRODUCTION: Aspergillus fumigatus is a ubiquitous soil-dwelling organism, which can cause both aspergillomas which develop in a preformed lung cavity, and aspergillus bronchitis. The two pathologies can occasionally co-exist, notably in patients with of cystic fibrosis. CASE REPORT: We describe a 57 year old patient, with diffuse bronchiectasis, who developed aspergillus bronchitis as well as an aspergilloma complicating a cavity caused by an atypical mycobacterial infection. After one month of therapy with voriconazole the aspergilloma had decreased in size and the endobronchial changes had resolved. CONCLUSION: This case report illustrates that in addition to its established role for the treatment of invasive aspergillosis, voriconazole is a promising new therapy for the treatment of aspergilloma and aspergillus bronchitis.
[Vaccine-induced urticaria: how to differentiate allergy (IgE) from pseudoallergy?].
BACKGROUND: The occurrence of allergic-type manifestations during the course of vaccination is relatively common, and in the majority of cases, these are benign reactions which are also known as "pseudoallergy". They are not immunological in nature and do not activate the effectors of specific immunity. OBJECTIVE: The aim of our work was to propose a practical diagnostic approach following an immediate and/or accelerated post-vaccination accident. PATIENTS AND METHODS: We report our experience in four adults who were referred for urticaria which appeared following vaccination and in two children who were allergic to eggs and were referred for assessment before administration of vaccines containing egg proteins. RESULTS: The immunoallergological examinations (prick-test and intradermal tests with immediate reading) confirmed the absence of immediate hypersensitivity to the vaccine in question and all the patients could be vaccined without incident. CONCLUSION: The majority of post-vaccination reactions with an allergic appearance is benign and do not contra-indicate further vaccination. If there is a suspicion of a true IgE dependent allergy, an immunoallergological investigation will differentiate true allergy from pseudoallergy.
[Urticaria paradoxically aggraved by H1 antihistamines].
BACKGROUND: H1 antihistamines (anti-H1) are the treatment of choice in chronic urticaria. We report five cases of urticaria, induced or aggravated by H1 antihistamines. METHODS: The immunoallergological investigations included prick-tests and intradermal tests with the antihistamine responsible for acute urticaria. RESULTS: The skin tests confirmed the non-IgE dependent nature of the urticarial eruptions and anti-leukotrienes (montelukast, Singulair) were effective in controlling chronic urticaria in 3/4 patients. DISCUSSION: Two hypotheses are discussed to explain the paradoxical aggravating effect of H1 antihistamines on the urticaria: 1) the patients are sensitive to the toxic, pro-inflammatory effect of the drug, which is the source of nonspecific activation of mast cells; 2) the fact that the urticaria is sensitive to anti-leukotrienes suggests that histamine is not the principal mediator of urticaria in these patients.
[Allergic reaction to methylprednisolone].
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Skin delayed-type hypersensitivity to josamycin.
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