Biomedical subjects

N Farrow

Publications and source records attributed to N Farrow.

8 recordsLinked to original sources

PubMed1998

In vivo MR spectroscopy of human dementia.

Nuclear MR spectroscopy in low and medium magnetic fields yields well-resolved natural abundance proton and decoupled phosphorus spectra from small (1-10 mL) volumes of brain in vivo in minutes. With this tool, neurochemical research has advanced through identification and noninvasve assay of a specific neuronal-cf2Ncf1-acetylaspartate, glial (cf2myocf1-inositol)-markers, energetics and osmolutes, and neurotransmitters (glutamate, GABA). From these simple measurements, several dozen disease states are recognized, including birth injury, and white matter and Alzheimer disease. Together, these tools are having a major impact on neuroscience and clinical medicine.

Alzheimer Disease↗

PubMed1997

In vivo magnetic resonance spectroscopy of human brain: the biophysical basis of dementia.

Nuclear magnetic resonance spectroscopy (MRS) in low and medium magnetic fields yields well-resolved natural abundance proton and decoupled phosphorus spectra from small (1-10 cc) volumes of brain in vivo in minutes. With this tool, neurochemical research has advanced through identification and non-invasive assay of specific neuronal--(N-acetylaspartate), glial (myo-inositol)--markers, energetics and osmolytes, and neurotransmitters (glutamate, GABA). From these simple measurements, several dozen disease states are recognized, including birth injury, and white matter and Alzheimer disease. Addition of stable isotopes of carbon (in man) or nitrogen (in experimental animals) has provided in vivo assays of enzyme flux through glucose transport, glycolysis, TCA-cycle, and the glutamine-glutamate-GABA system. Finally, a number of xenobiotics are recognized with heteronuclear NMR techniques. Together, these tools are having a major impact on neuroscience and clinical medicine. Through diagnosis and therapeutic monitoring, a new generation of in vivo metabolite imaging is expected with the advent of conforming RF coils and higher field NMR systems.

Animals↗

PubMed1991

Localized 1H NMR spectroscopy in patients with chronic hepatic encephalopathy. Analysis of changes in cerebral glutamine, choline and inositols.

Localized, short echo 1H magnetic resonance spectra from an area in the parietal cortex of three patients suffering from chronic hepatic encephalopathy are compared with equivalent spectra obtained from healthy control subjects. Three significant differences are found: elevated glutamine, decreased inositol, and decreased choline peak intensities. The elevation of cerebral glutamine concentration is expected as a consequence of the presumed chronic hyperammonemia in this disease. The finding of a 50% change in the inositol peak is physiologically unexpected and so far unaccounted for. Data acquisition and processing parameters are described in detail. To further define spectral abnormalities, which were readily detected in untransformed spectra, a simple data analysis scheme has been used that consists of post-acquisition low-frequency filtering, a lineshape transformation, and a difference technique to clarify spectral changes.

Aged↗

PubMed1991