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Biomedical subjects

N Ehlers

Publications and source records attributed to N Ehlers.

At least 127 records · Page 7Linked to original sources
PubMed1978

A double-blind study of the influence of tranexamic acid on the central corneal thickness after cataract extraction.

A double-blind study of the influence of systemic tranexamic acid on the central corneal thickness after cataract extraction was performed in 17 pairs of patients. Apart from the cataract, no were present. A sequential statistics was used to show that the increase in central corneal thickness after operation was significantly less in the tranexamic acid treated group than in the placebo group. There was no significant difference in intraocular pressure between the tranexamic acid and the placebo treated group. The possible influence of tranexamic acid on the thickness controlling mechanism of the cornea is discussed, and studies concerning the fibrinolytic system, the complement system and the aqueous humour amino acid treated patients are mentioned.

Aged↗
PubMed1978

Management of late corneal graft problems.

Immediately after an operation the corneal graft is taken care of by the surgeon, but after a certain period of time the control lies in the hands of the general ophthalmologist. Examples of the management of different kinds of postoperative complications are presented. Early correct treatment of any graft problem is of decisive importance. Careful slit-lamp examination and measurement of graft thickness is stressed and the prompt use of systemic and subconjunctival steroids is recommended for incipient graft failure. Systemic tranexamic acid may also be useful.

Adrenal Cortex Hormones↗
PubMed1978

Central thickness in corneal disorders.

In the single individual the central corneal thickness (CCT) shows only small variations. Therefore CCT has been studied in a number of corneal diseases in order to investigate if this dimension might contribute to the diagnosis or to the understanding of the pathogenesis. Normal CCT was found in hereditary dystrophies with the exception of the macular dystrophy of Groenouw (type II), which showed a significantly reduced thickness. Reduced CCT was found in chronic degenerations of leutic, tuberculous or indefinite nature. Marginal degenerations of Fuchs-Terrien type also showed reduced CCT. The possible role of abiotrophic processes in this corneal thinning is dicussed. Endothelial dysfunction is indicated by increased CCT. This occurs in bullous keratopathy and in many acute disorders. Vascularisation of the cornea does not preclude the occurrence of normal or even reduced thickness.

Chronic Disease↗
PubMed1978

Amino acid transport in human ciliary epithelium.

A statistical study of the co-variation of the concentrations of 19 amino acids and related compounds from 21 persons was performed as a factor analysis of Caq/Cpl and of Caq. Six factors explained about 83% of the observed variation. Factor 1 showed a correlation to alpha-amino-N-butyric acid, valine, methionine, isoleucine, leucine, tyrosine and phenylalanine, factor 2 to lysine, histidine, arginine and glutamine (containing serine), factor 3 to taurine and proline, factor 4 to glycine and cystine, factor 5 to urea and factor 6 to glutamic acid. Only alanine and threonine showed a correlation to different factors in the Caq/Cpl- and the Caq-matrix. This correlation of groups of substances to different and independent factors is considered to be an argument in favour of the existence of six transport systems in the ciliary epithelium for the investigated substances.

Amino Acids↗
PubMed1978

Free light chains in serum during short course immunosuppression after corneal transplantation.

The effect of low doses of prednisone on the serum concentration oflight chains, IgG, IgA and IgM in nineteen corneal transplanted patients was investigated. Prednisone in doses of 30 mg daily for 6 days had an instantaneous effect on the concentration of light chains resulting in a mean decrease of 16.5% in relationship to the pre-treatment values. Decrease in the prednisone dose to 15 mg daily was followed by normalization of the light chain concentration. The effect of prednisone on the IgG concentration was less pronounced and more delayed. A mean decrease for IgG of 9.0% of the pre-treatment values was found. Minimum IgG concentration was found 3 weeks later than the minimum for light chains. Differences in the metabolization rate of light chains and IgG is suggested as an explanation for this. The concentration of IgA and IgM was unchanged during treatment. Correlation between corneal rejection and changes in the level of light chains or IgG was not found.

Adolescent↗
PubMed1977

Bullous keratopathy (Fuchs' endothelial dystrophy) treated systemically with 4-trans-amino-cyclohexano-carboxylic acid.

Twenty patients with bullous keratopathy (Fuchs' endothelial dystrophy) were treated systemically with the antifibrinolytic drug tranexamic acid. The effect was evaluated by slit-lamp biomicroscopy, measurement of central corneal thickness and determination of visual acuity. The patients subjective complaints were also registered. The duration of the treatment varied from 3 to 16 months. In most cases the treatment was given over several periods with intervening free intervals. In all cases the central corneal thickness decreased and slit-lamp biomicroscopy revealed an improvement. The visual acuity improved and all patients became free of pain. A possible mechanism involving the complement system is discussed and preliminary studies on the composition of the aqueous humour in cases of bullous keratopathy are mentioned.

Aged↗
PubMed1977

Clinical copper metabolism parameters in patients with retinitis pigmentosa and other tapeto-retinal degenerations.

Reports have appeared of abnormal copper metabolism in retinitis pigmentosa, and of a family with vitelliform retinal degeneration in which other members suffered from hepatolenticular degeneration. In the present study 15 patients with retinitis pigmentosa, 4 with various other retinal degenerations, and 1 with a family disposition to retinitis pigmentosa were examined. The copper concentration in serum and the coeruloplasmin concentration in plasma were found to be within normal limits. In 9 of the patients with retinitis pigmentosa the urinary excretion of copper per 24 hours was determined and was found to be normal. The results of the present study lend no support to the hypothesis of abnormal copper metabolism in retinitis pigmentosa.

Adolescent↗
PubMed1977

Corneatransplantation and matching for HLA-A and B.

Analysis of 140 corneatransplantations performed without selection showed a significant correlation between the HLA-A and B match and the clinical outcome. Furthermore, a highly significant correlation was found between rejection episodes and a positive direct cell-mediated lympholysis.

Corneal Transplantation↗
PubMed1976

Occurrence of lymphocytotoxic lymphocytes and antibodies after corneal transplantation.

Twentyfive recipients of penetrating corneal grafts were investigated for the presence in the peripheral blood of cytotoxic lymphocytes by the Direct Cell Mediated Lympholysis (Direct CML) test as well as for lymphocytotoxic antibodies. Eight patients presented a positive Direct CML. Six of these patients have shown clinical signs of graft rejection, while two patients had a clinically uncomplicated course. Only one of the 25 patients had lymphocytotoxic antibodies. This patient showed a negative Direct CML, and a clinically uncomplicated course.. The findings seem to imply that recipients of corneal grafts can be immunized by their grafts and that cytotoxic lymphocytes in peripheral blood appear frequently in those patients showing graft rejection.

Adult↗
PubMed1976

Demonstration of the hemiopic border in the normal person.

The hemiopic border is the vertical line in the visual field separating the two halves which represent each cerebral hemisphere. This border, which becomes clinically manifest in the hemiopias, may be demonstrated in the normal person either (1) by covering an eye with the palm of the hand while facing the sun with the eyes closed, or (2) by fixing a near point and observing the background while the two eyes are dissociated by red and green glasses, or (3) by two-object perimetry, in which an inhibition may be observed along the vertical median through the fixation point.

Functional Laterality↗
PubMed1976

Central cloudy corneal dystrophy of François.

A family is reported with central cloudy dystrophy of the cornea, as described by François in 1956. The lesion consists of a grey zone deep in the stroma, made up of polygonal or rounded areas with indistinct margins, separated by apparently clear, normal stroma. No deposits are visible in the slit lamp. The anterior and posterior boundary layers appear normal. The corneal thickness is normal. Open angle glaucoma was present in the family. The pathogenesis of the dystrophy is unknown, and histopathological examination has not been described. The differential diagnosis is briefly discussed. The family tree is suggestive of a dominant mode of transmission.

Adolescent↗
PubMed1976

Visual functions after perinatal macular haemorrhage.

Perinatal macular haemorrhage has been suggested as being a cause of amblyopia and strabismus. 39 of 48 children with macular haemorrhage after birth were examined at the age of 5 years. The study comprised visual acuity with E-test types and cycloplegic refraction. Binocular function was evaluated by cover test, and 4d-prism test. Fixation was studied by an ophthalmoscope with a central dark star. Sensory function was estimated by Schober test and Worth 4-dot-test. The observations gave no support to the existence of organic amblyopia or strabismus following perinatal macular haemmorrhage.

Amblyopia↗
PubMed1976

Central corneal thickness in newborns and children.

Central corneal thickness was measured optically in premature and full-term babies and in children. The thickness was found to decrease from the values found in premature and full-term babies to those found in small children aged between 2-4 years. The thickness of the adult cornea is reached at the age of about 3 years. These findings are discussed with respect to the possible role of corneal thickness as a biometric parameter, to intraocular pressure measurement, and to corneal thickness steady state regulation.

Adolescent↗