Structure of cloned DNA complementary to rat prolactin messenger RNA.
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Biomedical subjects
Publications and source records attributed to N E Cooke.
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The plasma-binding protein for vitamin D and its metabolites (DBP) is bound with high affinity (KA approximately 10(7) M-1) and specificity by a 40,000-dalton protein which is a proven constituent of all tissue cytosols examined. This association may be important for in vivo sterol transfer, but its role is currently not defined.
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The paper presents the case history of a 15-year-old boy with traumatic tetraplegia who developed hypercalcaemia within 6 weeks of injury. The condition was initially controlled by the infusion of intravenous fluids in large amounts and by the administration of calcitonin. After 3 weeks, calcitonin became ineffective. Eventually the hypercalcaemia responded to cortisone administered in low dosage. The endocrinologic implications of this observation are discussed.