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Biomedical subjects

N Davis

Publications and source records attributed to N Davis.

At least 73 records · Page 4Linked to original sources
PubMed1984

Breast cancer in association with lobular carcinoma in situ. Clinicopathologic review and treatment recommendation.

A 6 year follow-up study of 80 women with coexisting lobular carcinoma in situ and infiltrating breast cancer has been conducted to emphasize the natural history and management of these cancers. Treatment of the contralateral breast is of utmost importance as lobular carcinoma in situ is a multicentric neoplasm associated with a subsequent high occurrence of invasive cancer. This series has documented a high incidence of bilateral cancer. Six patients (7.5 percent) had simultaneous bilateral tumors and eight patients (10 percent) had the subsequent development of a second primary tumor, representing approximately four times the expected rate. Despite a well structured out-patient department, follow-up was suboptimal. Six of eight metachronous tumors were detected at a late stage (T2 and greater).

Adult↗
PubMed1983

Squamous cell carcinoma of the tongue and lower oral cavity in patients under 40 years of age.

Squamous cell carcinoma of the tongue and lower oral cavity is uncommon in patients under the age of 40 years. The site distribution and male to female ratio of patients differed markedly from those of the overall squamous cell carcinoma group. The tongue was by far the most common site, and the majority of patients were women. There were no apparent etiologic or biologic factors noted. Lymph node metastases occurred in 38 percent of our patients and were present in six of seven tumor-related deaths. Those patients who died usually had a poor response to initial treatment, and most were dead within less than 2 years after diagnosis. The overall cure rate in our study patients was much better than that for the overall group of patients, and this was especially so in patients with tongue cancer (80 percent absolute cure rate). Aggressive treatment and careful follow-up for recurrence or metastases are necessary.

Adolescent↗
PubMed1982

Serum calcitonin response to administration of calcium in newborn infants during exchange blood transfusion.

In 25 newborn infants, 30 "exchange" transfusions were performed. Pre-exchange serum calcitonin concentrations of newborn infants were higher than those of normal adults and of donor blood used for exchange transfusion. A gradual decline of serum calcitonin concentrations was observed with increasing postnatal age. Serum calcium and magnesium concentrations were inversely related to serum calcitonin concentrations. Newborn infants had significant elevations of serum calcitonin values within a few minutes after the administration of calcium. Gestationally younger infants (less than or equal to 33 weeks) had significantly more pronounced and swifter elevations of serum calcitonin concentrations after calcium administration than gestationally more mature infants (less than 33 weeks). We speculate that calcitonin may be an important "fetal hormone" and that increased calcitonin concentrations may relate to the pathogenesis of neonatal hypocalcemia.

Calcitonin↗
PubMed1982

Spastic diplegia and the significance of mothers' previous reproductive loss.

In order to explore the relationship between spastic diplegia and mothers' previous reproductive loss, 119 cases of spastic diplegia born between 1953 and 1977 were compared with two series of controls. One control group comprised a random sample of all births, the other a random sample of births matched for birthweight and length of gestation. A demonstrable difference in previous reproductive histories was found between mothers of cases of spastic diplegia and mothers of the first series of controls, but there was no such difference between mothers of cases and mothers of the second series. This suggests that the reproductive histories of mothers of cases of spastic diplegia are not unique, and that their unusual number of reproductive losses is related to the child's associated fetal growth-retardation and not to the presence of diplegia.

Abortion, Spontaneous↗
PubMed1981

Characterization and mapping of RNase III cleavage sites in VSV genome RNA.

Ribonuclease III cleaves the genome RNA of vesicular stomatitis virus (VSV) to yield an array of fragments which range in size from 3.5 to 0.1 x 10(6) daltons under partial digestion conditions. The locations of the RNase III cleavage sites which give rise to these fragments have been ordered relative to the 3' end of the virion RNA by digestion of 3' end-labeled RNA. Based on a map of the cleavage sites we predicted that fragments having the same size could be generated which contain information from each gene. Annealing of individual VSV mRNA probes to Northern blots of the separated RNase III-generated fragments confirmed that fragments having the same size are, in fact, generated which contain information from each coding region of the VSV genome. Analysis of maps of partial digestion products indicates that fragments having the same size arise repeatedly along the 3' half of the genome. The cleavage of VSV RNA by RNase III can be detected only if the nuclease treated molecules are denatured. This suggest that the structure features in VSV RNA which signal cleavage involve areas of higher order RNA structure.

Base Sequence↗
PubMed1980

Changing epidemiology of malignant melanoma in Queensland.

Information provided by Queensland pathology laboratories shows that the annual incidence of cutaneous malignant melanoma in Queensland has doubled from 16 per 100 000 population in 1966, to 32.7 per 100 000 in 1977. The incidence in males, and the males to females ratio have increased. The major sites of the tumour remain the same, except possibly for a reduction in the number of leg tumours in females in tropical Queensland. More tumours with an in-situ component of Hutchinson's melanotic freckle type are being diagnosed. The tumours diagnosed in 1977, compared with those in the Queensland Melanoma Project files from 1963 to 1969, are more superficial (Level 1 or Level 2), with nonelevated profile and smaller diameter. The findings suggest that the disease is being diagnosed and treated earlier.

Adolescent↗
PubMed1979

Take it off.

Explore the source record for details and available documents.

Dental Enamel↗
PubMed1978

Modern concepts of melanoma and its management.

Malignant melanoma can be diagnosed at an early biological stage when relatively simple excisional surgery carries a remarkably good prognosis. For this to happen requires good public education, so that patients are aware of the potential danger of any change in a mole, and good professional education, so that physicians of first contact are alert to the possibility of melanoma in these patients.

Humans↗