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Biomedical subjects

N D Zinder

Publications and source records attributed to N D Zinder.

At least 91 records · Page 5Linked to original sources
PubMed1971

Structure of the poly(G) polymerase component of the bacteriophage f2 replicase.

A rifampicin-resistant poly(G) polymerase has been purified from f2 sus 11-infected cells. The poly(G) polymerase is believed to represent part of the f2 replicase on the basis of several criteria. It is present only in infected cells and shares the characteristic rifampicin resistance of crude f2 replicase activity. Partially purified poly(G) polymerase preparations exhibit replicase activity, synthesizing f2 "lus"strand RNA from denatured, partially double-stranded f2 RNA template. Highly purified poly(G) polymerase preparations, although lacking replicase activity, contain a protein which is electrophoretically identical to the protein product of the viral replicase cistron.

Carbon Isotopes↗
PubMed1969

A mechanism for genetic recombination generating one parent and one recombinant.

A mechanism is proposed for generating one parental and one recombinant genome in a single recombination event between two DNA molecules. Three stages of the event are described: initiation, replication, and return. Initiation requires breakage and joining of strands. Replication proceeds through a biparental "replication fork" generated in initiation. Return also involves breakage and joining of strands. Some of the implications of such a mechanism for genetic recombination are discussed.

Bacteriophages↗