Search PubMed⌕ Search

Biomedical subjects

N D La France

Publications and source records attributed to N D La France.

3 recordsLinked to original sources
PubMed1990

Decrease in xenon clearance during response to cold, dry air: problems of interpretation.

In order to increase our understanding of the nasal response to cold, dry air (CDA), we studied changes in xenon clearance as an indicator of nasal blood flow. Eight individuals previously shown to respond to CDA had measurements of xenon clearance made in the left inferior turbinate before, during, and after a 15-minute exposure to either CDA (-7 degrees C to 0 degrees C, less than 10% relative humidity) or room air. The half-life in seconds for xenon clearance on the day when CDA was inhaled was 56 +/- 6, 41 +/- 5, and 110 +/- 31, before, during, and 10 minutes after challenge, respectively. On the control day, with subjects breathing room air, the equivalent measurements of half-life in seconds were 54 +/- 8, 41 +/- 6, and 42 +/- 4, respectively. Xenon clearance was prolonged significantly (p less than .01) after exposure to CDA during the clinical response. The interpretation of the change in xenon clearance as an indicator of nasal blood flow is discussed.

Air↗
PubMed1989

CT of severe renal trauma in children: evaluation and course of healing with conservative therapy.

Over a 2-year period, blunt renal injuries were classified on a four-point scale: grade 1, contusions; grade 2, tears limited to the cortex (renal lacerations); grade 3, tears extending to the collecting system (renal fractures); and grade 4, renal vascular pedicle injuries. We report our findings in nine children with grade 2 and grade 3 blunt renal injuries who were evaluated with CT. One patient had a nephrectomy; the other eight were managed nonsurgically. Six patients had follow-up CT scans 5-19 months later to assess healing. Scars were evident in each case, and the extent of deformity paralleled the magnitude of the initial injury. One patient with a grade 2 injury and two patients with grade 3 injuries healed with small focal scars; three patients with grade 3 injuries healed with large polar scars. In five patients, the CT findings were compared with the findings on 99mTc-DTPA renal imaging. The injured kidneys contributed 30-45% (mean, 38%) of total renal function. In six patients with renal trauma who were treated conservatively, the involved kidneys healed and significant kidney function was preserved, although early surgical intervention might have been beneficial for one of these patients. Prospective studies are needed to evaluate further the effectiveness of this conservative approach.

Child↗